An analysis of 184 patients with anatomically resectable pancreatic cancer and elevated CA19-9 levels demonstrated that those receiving intensive neoadjuvant chemotherapy (NAC) showed significantly improved overall survival compared to those undergoing upfront surgery, with median survival times of 52.7 months versus 22.7 months (p < 0.001). Additionally, higher lymph node-negative resection rates and better post-resection […]
Category: HPB & Spleen
Multimodal system enhances diagnostic accuracy for hepatic conditions
A deep learning diagnostic system combining CT and ultrasound achieved superior accuracy in detecting hepatic echinococcosis and other liver conditions compared to individual modalities and physician evaluations. The integrated model demonstrated an impressive accuracy of 81.6% in internal tests and 84.9% in external assessments, with high sensitivity and specificity. This innovation significantly reduces misdiagnosis rates, […]
Nivolumab plus ipilimumab improves overall survival in patients
Nivolumab combined with ipilimumab significantly enhances overall survival for patients with untreated unresectable hepatocellular carcinoma compared to lenvatinib or sorafenib. After a median follow-up of 35.2 months, the median overall survival was 23.7 months for nivolumab plus ipilimumab, versus 20.6 months for the other treatments. Although initial higher death rates were observed within the first […]
New microRNA panel predicts pancreatic cancer recurrence post-surgery
A novel axon guidance-related microRNA panel (AGMP) has shown exceptional predictive capabilities for local recurrence in pancreatic cancer patients following curative surgery. This model, trained on diverse cohorts, achieved an AUC of 0.95 in the training cohort and maintained high validation scores across three independent cohorts ranging from 0.90 to 0.94. Additionally, the AGMP demonstrated […]
Minimally invasive surgery shows promise for gallbladder cancer
A comparison of minimally invasive surgery (MIS) and open radical cholecystectomy for gallbladder cancer revealed no significant difference in mortality or major morbidity. However, MIS patients experienced shorter hospital stays and lower rates of blood transfusions and superficial surgical site infections. Specifically, the average hospital stay was three days for MIS compared to five for […]
Omental wrapping with stenting reduces complications after surgery.
A new surgical technique using omental wrapping and stenting around pancreaticojejunal anastomosis significantly reduced postoperative complications. In a study of 48 patients undergoing pancreaticoduodenectomy, group B, which received the omental flap and stent, showed lower rates of pancreatic fistula (4.2% vs. 20.8%), hemorrhage, biliary fistula, and delayed gastric emptying. This group also experienced reduced overall […]
Genetic profiling predicts chemotherapy response in colorectal liver metastasis
A study involving 230 Chinese patients with colorectal liver metastasis identified significant predictors for chemotherapy response. Key factors included gender, the use of biological targeted agents (BTAs), and specific mutations in the KRAS gene and other rare genes. A predictive model achieved an area under the curve (AUC) of 0.73, indicating that around 75% of […]
KRAS status impacts surgical outcomes for colorectal liver metastases
A study involving 220 patients revealed that KRAS mutations negatively affect long-term outcomes after thermal ablation (TA) and liver resection (LR) for colorectal liver metastases (CRLM). Among patients with mutated KRAS, factors like synchronous disease and the performance of multiple TAs significantly influenced disease-free survival. Furthermore, while TA was associated with liver-only recurrences in both […]
New guidelines aim to improve outcomes for HCC patients
A consensus from Chinese experts has established eight recommendations for diagnosing and treating hepatocellular carcinoma (HCC) with microvascular invasion (MVI). These guidelines emphasize the use of MVI grading criteria and the EH-BH nomogram for improved accuracy in prediction and management. The goal is to enhance recurrence-free survival and overall survival rates among HCC patients facing […]
Single-stage techniques improve outcomes in choledocholithiasis management
Management of choledocholithiasis has evolved towards single-stage techniques, which demonstrate significantly lower 30-day morbidity and shorter hospital stays compared to traditional two-stage laproendoscopic approaches. Intraoperative endoscopic rendezvous procedures show further enhanced patient outcomes by minimizing the risk of post-endoscopic pancreatitis. Additionally, laparoscopic common bile duct exploration offers superior stone clearance rates, reduced costs, and efficient […]