A study identified a 70.9% postoperative recurrence rate for type iii-iv in hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion. Key independent risk factors included young age, large tumor size (≥10 cm), and high Ki67 index. Two nomograms—pre- and postoperative—demonstrated strong prediction capabilities with ROC curve areas of 0.827 and 0.891, respectively. Both models effectively […]

Monitoring circulating tumor DNA (ctDNA) provides critical prognostic insights for patients with resected extrahepatic cholangiocarcinoma (eCCA). Findings demonstrate that ctDNA positivity before and during adjuvant chemotherapy is associated with significantly inferior disease-free survival (DFS). Notably, patients who remained ctDNA-negative experienced a markedly longer DFS. These results emphasize ctDNA’s potential in guiding clinical decisions concerning treatment […]

A study of 216 patients with hepatitis C virus-related hepatocellular carcinoma demonstrated that those achieving a sustained virologic response (SVR) through direct-acting antiviral therapy, either pre- or post-surgery, had significantly improved overall and recurrence-free survival rates compared to those without SVR. Specifically, the hazard ratios indicated that SVR was a strong independent predictor of both […]

A study involving 131 non-surgical pancreatic ductal adenocarcinoma patients revealed that radiomics features from baseline CT images could significantly predict overall survival. Out of 845 extracted features, 45 were notably different among survival tertiles. The developed radiomics score demonstrated significant differentiation (p = 0.034) and overall survival differences (p = 0.02). The predictive nomogram exhibited […]

A retrospective analysis of 578 pancreatoduodenectomy patients revealed that 42.91% achieved an ‘ideal outcome’ (io). Key factors enhancing io likelihood included neoadjuvant chemotherapy and neuroendocrine tumors. In contrast, older age and percutaneous transhepatic biliary drainage reduced the odds of achieving io. Notably, patients with io demonstrated significantly improved survival rates, underscoring the potential for refined […]

A study examining minimally invasive surgery (MIS) for hepatic and pancreatic procedures found significant benefits compared to open surgery. Among 8,705 patients, MIS was associated with a mean decrease in 1-year post-discharge healthcare costs of $9,739 and fewer missed workdays. After adjusting for factors such as demographics and comorbidities, the results highlighted that MIS not […]

A study evaluating the Enhanced Recovery After Surgery (ERAS) protocol for laparoscopic common bile duct exploration (LCBDE) found marked improvements in patient outcomes. The ERAS group experienced significantly lower anxiety levels and complication rates (p < 0.05). Additionally, they reported reduced postoperative pain scores, achieving a satisfaction rating of 90% and a recovery time of […]

A systematic review evaluated 1,417 patients undergoing liver resections with either ultrasonic devices or clamp-crushing techniques. While the clamp-crush method yielded shorter operation times, the ultrasonic group demonstrated significantly less blood loss and lower transfusion rates. Both groups had comparable mortality and postoperative bleeding rates; however, the ultrasonic devices were linked to a notably lower […]

A complex parenchyma-sparing hepatectomy was successfully performed on a 61-year-old woman with multiple bilobar colorectal liver metastases after she showed a partial response to second-line chemotherapy. Utilizing advanced three-dimensional reconstruction and intraoperative ultrasound for guidance, clinicians executed a unique transection of several liver segments, significantly preserving healthy tissue while addressing extensive disease. This innovative approach […]