A novel deep-learning model, known as DEAF, accurately predicts the completeness of cytoreductive surgery (CRS) in colorectal cancer patients with peritoneal metastasis. Achieving an area under the curve (AUC) of 0.9 in the internal validation cohort, and higher AUC values in three external cohorts, the model aids in selecting suitable patients for surgery and anticipating […]
Category: Intestine and Lower Gastrointestinal Tract
Transanal total mesorectal excision improves outcomes for rectal cancer.
Transanal total mesorectal excision (TaTME) demonstrated superior clinical outcomes in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy (NACRT). A study involving 91 patients revealed TaTME resulted in lower operative time, blood loss, transfusion needs, morbidity, and shorter hospital stays compared to open and laparoscopic surgeries. Additionally, three-year relapse-free survival and local recurrence-free survival […]
Optimal platelet count threshold established for colonoscopic polypectomy
A large-scale analysis identified a minimum platelet count of 90,000/μl as crucial for safe colonoscopic polypectomy, indicating that patients below this threshold face significantly heightened risks of both immediate and delayed postpolypectomy bleeding (ppb). Specifically, odds ratios indicated a 2.67-fold increase in immediate ppb and a 9.66-fold increase in delayed ppb among those with insufficient […]
Circular skin closure significantly reduces surgical site infections
A systematic review and meta-analysis revealed that circular skin closure (CSC) markedly decreases the rate of surgical site infections (SSI) following stoma closure compared to primary sutures (PS). Researchers found that only 4% of patients using CSC developed SSI, in contrast to 27% in the PS group. This analysis, which included eight randomized controlled trials […]
Extraperitoneal colostomy reduces complications after laparoscopic APR
A systematic review involving 1,002 patients revealed that extraperitoneal colostomy (EPC) significantly lowers the incidence of parastomal hernia compared to transperitoneal colostomy (TPC) after laparoscopic abdominoperineal resection for rectal cancer. The EPC technique also showed reduced rates of stoma retraction, prolapse, and overall stoma-related complications. Importantly, both approaches did not differ significantly in total operative […]
Contact X-ray brachytherapy offers effective treatment for rectal cancer
A systematic review and meta-analysis reveals that contact X-ray brachytherapy (CXB) provides an 82% clinical complete response rate in rectal cancer patients, presenting a compelling alternative to radical surgery. With a 14% salvage surgery rate and 81% organ preservation, CXB demonstrates long-term disease control, particularly beneficial for stoma-averse and older patients. The findings suggest clinicians […]
Watch-and-Wait yields favorable outcomes in rectal cancer patients
Broad implementation of Watch-and-Wait for rectal cancer in the Netherlands shows promising results. Among 1,080 patients, 45% achieved clinical complete response post-treatment, with a three-year organ preservation rate of 76%. The study also found a 23% incidence of local regrowth and an overall survival rate of 97%. Notably, no significant differences in regrowth or metastases […]
Uniform prehabilitation protocols improve outcomes for colorectal surgery patients
Researchers aim to assess the impact of standardized prehabilitation protocols on clinical outcomes for colorectal cancer patients in the Netherlands. By recruiting 1,070 patients, including those undergoing prehabilitation and a matched historical cohort, they will analyze postoperative complications, length of hospital stay, and readmission rates. The study seeks to establish a clear clinical effect of […]
EUS-guided drainage proves effective for complicated diverticulitis
EUS-guided pelvic abscess drainage (EUS-PAD) using lumen-apposing metal stents demonstrates high efficacy and safety in managing complicated acute diverticulitis. In a study involving 53 patients, the procedure achieved a technical success rate of 92.5% and a clinical success rate of 88.7%. Adverse events were minimal, occurring in 3.8% of cases, with no procedure-related mortalities. EUS-PAD […]
Faecal immunochemical test screening matches colonoscopy in safety
A pragmatic trial involving 57,404 individuals revealed that faecal immunochemical test (FIT) screening is non-inferior to colonoscopy in reducing colorectal cancer mortality over 10 years. Participation rates were higher for FIT at 39.9% compared to colonoscopy’s 31.8%. The colorectal cancer mortality risk was nearly identical between the two groups, suggesting that a FIT-based screening program […]