Centralization of ileo-anal pouch surgery in high-volume centers enhances patient outcomes by reducing pouch failure rates, improving reconstruction rates, and lowering readmission and complication rates. This systematic review underscores the importance of specialized care in improving outcomes for patients undergoing pouch surgery for inflammatory bowel disease, advocating for centralization to dedicated units for enhanced patient […]

Tumour-infiltrating lymphocytes (TIL) and microsatellite instability (MSI) status are key prognostic factors in colorectal cancer. A meta-analysis of 14,028 patients revealed that TIL-high (TIL-H) subtype correlated with improved overall survival. The integrated MSI-TIL classification shows promise as a predictive tool for clinical decisions in early-stage colorectal cancer. Further exploration is warranted for its potential clinical […]

Study investigates the combined tumor markers CEA and CA19-9 in colon cancer patients. 531 patients underwent curative resection, with higher preoperative and postoperative tumor marker levels associated with lower recurrence-free and overall survival rates. Patients with elevated postoperative tumor markers had increased risk of recurrence and death. Normalization of markers post-surgery improved prognosis. Postoperative tumor […]

Perineural invasion is an independent poor prognostic factor in stage III colon cancer but does not predict outcomes in node-negative disease. Adjuvant chemotherapy benefits patients with node-positive but not those with node-negative disease when perineural invasion is present. Higher recurrence odds are seen only in poorly differentiated tumors among perineural invasion-positive tumors. Findings discourage adjuvant […]

High county-level provider density is linked to lower colorectal cancer-related mortality rates, independent of social vulnerability index. Efforts to increase access to health care providers could enhance health care equity and long-term cancer outcomes. Low provider density areas exhibited higher crude mortality rates compared to moderate or high provider density areas. This study underscores the […]

Preoperative aerobic fitness, along with other factors like age, sex, and tumor location, can predict postoperative complications and physical recovery time in colorectal cancer surgery patients. The developed models show moderate discrimination and good calibration, offering a promising tool for personalized risk assessment and targeted prehabilitation strategies. Journal Article by Cuijpers ACM, Lubbers T (…) […]

Delayed surgical intervention of more than three days in elderly patients diagnosed with intestinal fistula significantly increases the risk of mortality, with nearly double the length of hospital stay compared to earlier surgical groups. Mortality rates were notably higher in patients with delayed surgeries, emphasizing the importance of timely operative treatment to minimize mortality risk […]

Real-time assessment of bowel perfusion using methylene blue and indocyanine green was successful in a porcine model, with MB showing a stronger correlation with local lactate levels compared to ICG. This study demonstrates the potential utility of MB as a viable alternative for assessing intestinal perfusion alongside ICG. Further research is needed to translate these […]

Utilizing the NIR-ICG imaging system during laparoscopic rectal cancer surgery can potentially reduce the incidence of anastomotic leakage (AL), a serious complication. The study protocol, a randomized controlled trial, aims to evaluate AL rates in patients receiving NIR-ICG during total mesorectal excision compared to conventional surgery. Expected outcomes and sample sizes have been carefully considered, […]