Category: Intestine and Lower Gastrointestinal Tract

Impact of Disease Phenotype and Biologic Therapy on Re-resection Rates in Crohn’s Disease

Re-resection rates in Crohn’s disease patients are significantly influenced by disease activity and stoma reversals. The study reveals that early initiation of biologic therapy after primary resection can reduce the risk of re-resection for specific disease phenotypes. Factors such as disease location, behavior, smoking, and perianal disease also play a role in re-resection. These findings […]

Long-term Outcomes of Primary Closure in Pilonidal Sinus Disease

Comparing two surgical techniques for pilonidal sinus disease, midline closure without skin sutures showed significant advantages over excision and primary closure. Patients in the midline closure group experienced shorter surgical procedures, hospital stays, and time to return to work. Additionally, they had lower complication rates and no recurrence during a five-year follow-up period. This technique […]

Relaparoscopy for Severe Complications in Laparoscopic Colorectal Surgery

Relaparoscopy, guided by a standardized interdisciplinary protocol, demonstrates efficacy in managing major complications after laparoscopic colorectal surgery, leading to reduced treatment failure rates, including lower 90-day mortality and need for further surgery. Relaparoscopy, particularly in cases of anastomotic leak, correlates with shortened hospital stays, decreased postoperative morbidity, and less intensive postoperative care, indicating its potential […]

WeChat-based Nursing Interventions on Mental Distress and Satisfaction

WeChat online education and care (WOEC) interventions significantly lowered depression and anxiety levels in caregivers of elderly postoperative colorectal cancer patients. Patient satisfaction scores were notably higher in the WOEC group compared to the control group. Subgroup analysis revealed that caregivers with lower performance status and higher education levels benefitted the most from WOEC. Overall, […]

Outcomes of Robotic Radical Surgery for Rectal GIST

Favorable short-term and long-term outcomes were observed in patients undergoing robotic radical surgery for rectal gastrointestinal stromal tumor (GIST), with 100% 5-year overall survival and recurrence-free survival rates. The majority of patients had negative surgical margins, underwent sphincter-preserving surgery, and experienced low postoperative complication rates, highlighting the potential utility of robotic surgery for this condition. […]

Improved Recurrence Surveillance with Personalized Circulating Tumor DNA Monitoring

Personalized circulating tumor DNA monitoring using a tumor-informed assay significantly improves recurrence surveillance and management in patients with colorectal liver metastases. Detectable ctDNA at specific time points post-surgery is associated with higher recurrence risk, serving as an independent prognostic marker. Longitudinal ctDNA analysis accurately predicts relapse, leading to increased secondary resection rates and improved outcomes. […]

Enhancing HIPEC Efficacy with Bromelain in Appendiceal Cancer

Bromelain enhances cytotoxicity and mucolytic activity in appendiceal cancer tumors, reducing mucin production and increasing drug effectiveness in heated intraperitoneal chemotherapy (HIPEC) treatments. Combined with N-acetylcysteine, bromelain significantly reduces mucin levels and boosts cell death pathways like apoptosis and autophagy. These findings suggest a promising role for bromelain as a potent pretreatment agent in augmenting […]

Deep Learning Improves Prediction of Response to Neoadjuvant Chemotherapy in Colorectal Liver Metastasis

Deep learning models applied to prechemotherapy imaging accurately predict response to neoadjuvant chemotherapy in colorectal cancer liver metastases, outperforming clinical models. A study on 95 patients found the deep learning model had an AUC of 0.77, superior to the clinical model’s AUC of 0.41, showing potential to identify nonresponders and guide patient management towards curative […]

Enhanced Preop and Intraop Strategies Improve Colon Cancer Outcomes

Patients with colon cancer at high risk of recurrence benefit from preoperative evaluation, neoadjuvant chemotherapy, and revised intraoperative strategies. Specialized treatments, including hipec intraoperative chemotherapy, improve outcomes for patients with occult peritoneal metastases. Optimized cytoreductive surgical procedures and peritonectomy reduce sites of metastases, enhancing the effectiveness of colon cancer resection. Review by Sugarbaker PH in […]