Researchers analyzed retrospective data from high-resolution anorectal manometry and patient-completed bowel habit and symptom diaries to evaluate the usefulness of the diary as a screening tool for disordered rectoanal coordination (DRC). They found that patients with a dyssynergic pattern (DP) during manometry had a higher prevalence of incomplete evacuation with loose or normal stool compared […]
Category: Intestine and Lower Gastrointestinal Tract
Study Finds Similar Mutation Rates in Racial Differences of Stage IV Colorectal Cancer Patients
A retrospective cohort study analyzed molecular profiling and mutation rates in stage IV colorectal cancer (CRC) patients. The study found significant increases in molecular testing rates for microsatellite instability (MSI), KRAS, and BRAF mutations over time. Black patients had higher odds of testing for MSI and BRAF mutations compared to white patients. However, there was […]
Textbook Oncologic Outcomes Enhance Survival in CRS and HIPEC for Colorectal Peritoneal Metastasis
Expert consensus was achieved on the definition of textbook oncologic outcomes (TOO) in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastasis. The consensus criteria included the absence of unplanned re-operations, severe postoperative complications, unplanned readmissions, 90-day postoperative mortality, and contraindications for chemotherapy within 12 weeks. In a cohort of 251 patients, […]
Precision Surgery Shows Promise for Colorectal Liver Metastases with Mutras Tumors
Patients with mutras colorectal liver metastases (crlm) may benefit from anatomic resection (AR) compared to nonanatomic resection (NAR), according to a systematic review and meta-analysis. The study found that AR was associated with a significant improvement in liver-specific disease-free survival and overall disease-free survival among patients with mutras tumors, but not among those with wild-type […]
Minimum Number of Lymph Nodes Required for Staging Adenocarcinoma of the Appendix
Researchers aimed to determine the minimum number of lymph nodes (lns) needed to accurately stage adenocarcinoma of the appendix. They analyzed data from 3,602 patients and found that harvesting at least ten lns was necessary to minimize the risk of missing lymph node positive (lnp) disease. Failing to evaluate at least ten lns was also […]
Local Therapy Improves Survival for Early Recurrence After Resection of Colorectal Liver Metastases
A study evaluated whether local therapy benefits patients who experience early recurrence after hepatectomy for colorectal liver metastases (CLM). Clinicopathologic data of 671 patients were analyzed, with 81% experiencing recurrence. Local therapy, including ablation, resection, or radiation, resulted in improved survival for patients with early, intermediate, or later recurrence. Treatment with local therapy, liver and […]
Improved Prognosis in Rectal Cancer: Pathological-Features-Modified TNM Staging
A retrospective population-based study developed a pathological-features-modified tumor node metastasis (TNM) staging system using machine learning ensemble methods to improve the prognostic accuracy for rectal cancer patients. The study cohort included 14,468 patients diagnosed between 2010 and 2015. Patients were categorized into four pathological groups based on the number of pathological features. The proposed staging […]
Subtotal Colectomy Offers Lower Risk of Dysplasia and Neoplasia in PSC-IBD Patients Compared to IPAA
In patients with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC), subtotal colectomy may be a viable surgical option for those with rectal sparing disease, as it was found to have no dysplasia or neoplasia in the residual colon or rectum. Endoscopic surveillance showed that 2% of patients who underwent total proctocolectomy with ileal […]
High-grade Tumors Increase Lymph Node Metastasis Risk in T1 and T2 Colorectal Cancer
Out of 765 patients with T1 and T2 colorectal cancer, 11.3% had lymph node metastasis (LNM), leading to a poorer recurrence-free survival (RFS) compared to patients without LNM (72.6% vs. 88.6%). Multivariable analysis revealed that high-grade tumors were a significant risk factor for LNM. Radical surgery should be considered for T1 and T2 colorectal cancer […]
Effects of Immunotherapy on Overall Survival in Rectal Cancer Patients
The study examined the impact of immunotherapy on overall survival (OS) in rectal cancer patients using a propensity score matched analysis of the National Cancer Database. Out of the total patients analyzed, only 2.5% underwent immunotherapy. The results showed that patients treated with immunotherapy had shorter OS compared to controls. However, when stratified by clinical […]