Validation of the international tumor budding consensus conference (itbcc) method for assessing tumor budding in colorectal cancer (CRC) revealed that normalization overcorrects tumor budding counts, resulting in the downgrading of many borderline cases. Despite this, tumor budding counts in a 0.95 mm2 field remained clinically predictive. These findings highlight the implications of normalization for risk […]

Local excision may be a reasonable approach for patients with low-risk histopathology and clinical stage T2N0M0 rectal adenocarcinoma, as it showed similar overall survival rates compared to radical resection. However, radical resection provided a significant survival advantage for patients with high-risk histology. Journal Article by Kramer SP, Swanson J (…) Baker MS et 6 al. […]

A quality improvement study investigated the impact of reducing postoperative laboratory testing after colorectal surgery. The intervention group showed a 33% reduction in labs per hospital stay, 26% reduction in labs per day, and a 49% increase in lab-free days. There were no differences in length of stay or readmissions between the intervention and non-intervention […]

Researchers achieved national consensus on the optimal and standardized technique for minimally invasive right hemicolectomy (MIrh) in colon cancer. The study involved formulating consensus statements and conducting three rounds of the Delphi technique with 76 colorectal surgeons. The development and validation of a video-based competency assessment tool (CAT) for MIrh showed high consistency among surgeons, […]

The study assessed the association between food insecurity and surgical outcomes in colorectal cancer patients. It found that high levels of food insecurity were linked to higher odds of nonelective surgery, 90-day readmission, extended length-of-stay, and complications. Patients with high food insecurity also had decreased odds of being discharged to home and achieving textbook outcomes. […]

Researchers conducted a systematic review and meta-analysis comparing laparoscopic surgery (LS) to open surgery (OS) in patients with colorectal cancer. They found that LS resulted in milder proinflammatory reactions, as indicated by lower concentrations of inflammatory markers such as interleukins and C-reactive protein. The difference was particularly notable within the first 9 hours after surgery. […]

The results of three phase Ib/IIa clinical trials show that treatment with ex vivo expanded allogeneic bone marrow-derived mesenchymal stem cells is safe and effective for severe perianal, rectovaginal, and peripouch fistulizing Crohn’s disease. At 6 months, 83.3% of perianal, 33.3% of rectovaginal, and 30.8% of pouch fistula treatment cohorts achieved combined clinical and radiographic […]

Interim analysis of a randomized Phase III trial comparing complete mesocolic excision (CME) with conventional surgery for right colon cancer showed that CME was associated with a significantly higher lymph node yield (25 vs. 20) and improved surgical quality indicators. No differences were observed in complications, mortality, or surgery duration. Hospital stay was even shorter […]

Intestinal autotransplantation (iatx) combined with extended resections of multiple organs, including the superior mesenteric artery (SMA), was performed on 10 patients with locally advanced or recurrent colon cancer invading the SMA. The study found that iatx, either alone or in combination with pancreaticoduodenectomy, is a safe procedure and is associated with a 68% recurrence-free survival […]