Patients with pancreatic neuroendocrine tumors (PNETs) and perineural invasion (PNI) face significantly worse outcomes post-surgery. PNI occurs in 24.4% of PNET patients and is linked to higher tumor grades and advanced disease stages. Patients with PNI have a median overall survival of 115.9 months, compared to no PNI patients whose median survival is not yet […]
Category: Sarcoma & rare tumors
Minimally Invasive Surgery Cuts Complications in Small Bowel Tumors
Minimally invasive surgery for small bowel neuroendocrine tumors shows significant benefits over open resection. MIS resulted in 54% lower odds of postoperative complications. Patients had shorter hospital stays (4 vs. 6 days) and fewer infections: skin/soft tissue (2.1% vs. 6.8%), urinary tract (0.5% vs. 2.4%), sepsis (0.2% vs. 1.2%). This approach enhances short-term outcomes and […]
Rising Rates of Gastric Neuroendocrine Tumors Change Surgical Care
Gastric neuroendocrine neoplasms are on the rise, necessitating improved prognostic tools for better surgical outcomes. Incidence increased 16-fold over 46 years, from 0.435 to 7.033 per 1,000,000 people. A newly developed nomogram showed superior predictive accuracy (c-index of 0.86) compared to the AJCC staging system. Understanding these risk factors—age, sex, tumor characteristics, and surgical intervention—can […]
Outcomes of Pancreatic Tumors Differ by Cancer Type
Surgeons need to know how outcomes differ between pancreatic neuroendocrine tumors (pnet) and ductal adenocarcinoma (pdac) after surgery. After pancreatoduodenectomy, ideal outcomes were lower for pnet (44.2%) vs. pdac (56.9%), with significantly higher severe complications (31.2% vs. 19.0%) and readmission rates (23.6% vs. 15.3%). In distal pancreatectomy, pnet had better ideal outcomes (60.1% vs. 57.1%), […]
Innovative Ex Vivo Surgery and Autotransplantation Successfully Treats IVC Leiomyosarcoma
Surgeons successfully performed an ex vivo liver resection and autotransplantation in a patient with extensive inferior vena cava leiomyosarcoma. The operation included en bloc tumor removal, extensive vascular reconstruction, and involvement of open-heart surgery techniques. After a 13-hour procedure and significant blood loss, the patient was discharged after a month and remains disease-free 16 months […]
New scoring system accurately predicts perforation risk in gastric tumor surgeries
A novel scoring system successfully identifies high-risk patients for intraoperative perforation during endoscopic resection of gastric gastrointestinal stromal tumors. Analyzing over 1,100 patients, the system considers tumor location, size, and growth pattern, achieving strong discrimination with AUCs above 0.8. Risk stratification reveals significant variations: low-risk patients face an 8.3% perforation rate, while high-risk patients experience […]
Robotic Surgery Proves Safe for Gastric Tumors
A fully robotic, ultrasound-guided technique for organ-sparing resection of gastric gastrointestinal stromal tumors (GISTs) yields impressive results. In a cohort of 46 patients, the procedure demonstrated no intraoperative complications and a postoperative morbidity rate below 5%. All surgeries achieved R0 resection with a median follow-up of 36 months showing a disease-free survival rate of 98%. […]
Endoscopic resection proves safe for early-stage duodenal tumors
In a comprehensive review of 40 patients with grade 1-2 duodenal neuroendocrine tumors, endoscopic resection emerged as a viable first-line treatment option. Notably, ligation-assisted endoscopic mucosal resection achieved a remarkable 100% complete resection rate, with only one case of perforation successfully managed endoscopically. During a mean follow-up of nearly five years, no patients experienced metastasis […]
Robotic, organ-sparing surgery shows high efficacy for gastric tumors
Minimally invasive, ultrasound-guided robotic resections for gastric gastrointestinal stromal tumors (GISTs) demonstrate remarkable safety and efficacy. A study of 46 patients, primarily with challenging tumor locations, revealed no intraoperative complications or conversions to open surgery. The approach resulted in less than 5% postoperative morbidity and an impressive median disease-free survival rate of 98% at 36 […]
Automated machine learning excels in predicting liver metastases.
A groundbreaking automated machine learning model has significantly improved the prediction of liver metastases in patients with early-onset gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Analyzing data from over 12,000 patients, the gradient boosting machine (GBM) algorithm achieved an impressive area under the curve (AUC) of 0.961 in the training set and 0.953 in validation. Key predictors included […]