In a study assessing salvage treatments for rectal neuroendocrine tumors (RNETs) under 10 mm, wide hot snare polypectomy (WHSP) showed superior outcomes. Of 121 patients analyzed, WHSP achieved an impressive 72.7% R0 resection rate compared to other methods. With a focus on effectiveness and safety, WHSP emerged as a rapid and straightforward approach for these […]
Category: Sarcoma & rare tumors
Inadequate surgical treatment affects non-functioning pancreatic neuroendocrine tumours.
A retrospective study of 384 patients undergoing surgery for non-functioning pancreatic neuroendocrine tumours revealed that 40% received potentially inadequate treatment. Of these, 34% experienced potential overtreatment while 6% were potentially undertreated. Key predictors of overtreatment included smaller tumour sizes and earlier surgical intervention, while larger tumour diameter indicated potential undertreatment. Patients facing undertreatment exhibited significantly […]
EUS and Surgery Enhance Treatment Options for Pancreatic Tumors
The review highlights the evolving role of endoscopic ultrasound (EUS) in managing pancreatic neuroendocrine tumors (PanNETs), addressing their increasing incidence and associated diagnostic and therapeutic challenges. EUS has advanced from solely a diagnostic tool to facilitating minimally invasive locoregional therapies. Surgical intervention remains paramount, especially for localized, low-grade PanNETs larger than 2 cm. Although not […]
Subgrading of G2 Pancreatic Neuroendocrine Tumors Reveals Behaviorally Distinct Subsets
Subgrading G2 pancreatic neuroendocrine tumors into 2A (Ki67 3% to < 10%) and 2B (10% to ≤ 20%) identifies distinct subsets with different metastasis rates and aggressiveness. G2B cases show significantly higher rates of liver/distant metastasis, lymph node metastasis, and histopathologic signs of aggressiveness compared to G2A. G2B tumors behave similarly to G3, suggesting they […]
Tumor Size and Serum Chromogranin A Levels Predict Metastatic Disease on DOTATATE Imaging
Larger tumor size and elevated serum chromogranin A levels are predictive of metastatic disease in patients with gastroenteropancreatic neuroendocrine tumors undergoing DOTATATE imaging. Patients with primary tumor size ≥2 cm, serum CGA level ≥150 ng/ml, and tumor grade g2 are at higher risk of metastases, indicating the potential use of these factors in identifying patients […]
Minimally Invasive Surgery for Gastric GIST Resections
Minimally invasive surgery for gastric gastrointestinal stromal tumour (GIST) resections showed increased utilization and improved perioperative outcomes over time. Complication rates decreased, duration of admission and operating time shortened, while the composite measure of textbook outcome (TO) increased. Minimally invasive surgery was associated with fewer complications, shorter hospital stays, and higher TO rates, with low […]
Liver Tumor Burden Predicts Prognosis in Metastatic Grade 1 GEP-NETs
In metastatic Grade 1 gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), a higher burden of liver disease significantly reduces progression-free survival (PFS). Patients with concomitant extra-hepatic involvement have a lower overall survival (OS) rate. Liver tumor burden emerged as the sole predictor of PFS. These findings suggest a need for more aggressive treatment strategies in metastatic Grade 1 […]
Endoscopic Ultrasonography for Residual Rectal Neuroendocrine Tumor Diagnosis
Endoscopic ultrasonography (EUS) is a sensitive method for identifying residual rectal neuroendocrine tumors (NETs) post-resection. EUS detection, with a high sensitivity of 94%, is superior to visual detection. Salvage endoscopic treatment, incorporating EUS, is safe and effective in managing incompletely resected NETs, with no recurrence observed in patients during follow-up. EUS shows promise in accurately […]
Minimally Invasive Surgery for Pancreatic Neuroendocrine Tumors
Minimally invasive surgery for left pancreatic resection in patients with resectable pancreatic neuroendocrine tumors reduces major complications and offers comparable long-term oncologic outcomes. A study comparing minimally invasive and open surgery showed lower rates of major morbidity, postoperative complications, and better outcomes with minimally invasive surgery. This suggests that minimally invasive surgery can be safely […]
Gender Impact on Survival in Small Intestinal Stromal Tumors
Male patients with small intestinal stromal tumors (SISTs) have a higher risk of mortality compared to females. Females exhibit superior overall survival and cancer-specific survival rates than males. Surgical intervention significantly improves survival outcomes in both genders. Gender, along with age, grade, TNM stage, surgery, and mitotic rate, serves as a predictive indicator for survival […]