Larger tumor size and elevated serum chromogranin A levels are predictive of metastatic disease in patients with gastroenteropancreatic neuroendocrine tumors undergoing DOTATATE imaging. Patients with primary tumor size ≥2 cm, serum CGA level ≥150 ng/ml, and tumor grade g2 are at higher risk of metastases, indicating the potential use of these factors in identifying patients […]
Category: Sarcoma & rare tumors
Minimally Invasive Surgery for Gastric GIST Resections
Minimally invasive surgery for gastric gastrointestinal stromal tumour (GIST) resections showed increased utilization and improved perioperative outcomes over time. Complication rates decreased, duration of admission and operating time shortened, while the composite measure of textbook outcome (TO) increased. Minimally invasive surgery was associated with fewer complications, shorter hospital stays, and higher TO rates, with low […]
Liver Tumor Burden Predicts Prognosis in Metastatic Grade 1 GEP-NETs
In metastatic Grade 1 gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), a higher burden of liver disease significantly reduces progression-free survival (PFS). Patients with concomitant extra-hepatic involvement have a lower overall survival (OS) rate. Liver tumor burden emerged as the sole predictor of PFS. These findings suggest a need for more aggressive treatment strategies in metastatic Grade 1 […]
Endoscopic Ultrasonography for Residual Rectal Neuroendocrine Tumor Diagnosis
Endoscopic ultrasonography (EUS) is a sensitive method for identifying residual rectal neuroendocrine tumors (NETs) post-resection. EUS detection, with a high sensitivity of 94%, is superior to visual detection. Salvage endoscopic treatment, incorporating EUS, is safe and effective in managing incompletely resected NETs, with no recurrence observed in patients during follow-up. EUS shows promise in accurately […]
Minimally Invasive Surgery for Pancreatic Neuroendocrine Tumors
Minimally invasive surgery for left pancreatic resection in patients with resectable pancreatic neuroendocrine tumors reduces major complications and offers comparable long-term oncologic outcomes. A study comparing minimally invasive and open surgery showed lower rates of major morbidity, postoperative complications, and better outcomes with minimally invasive surgery. This suggests that minimally invasive surgery can be safely […]
Gender Impact on Survival in Small Intestinal Stromal Tumors
Male patients with small intestinal stromal tumors (SISTs) have a higher risk of mortality compared to females. Females exhibit superior overall survival and cancer-specific survival rates than males. Surgical intervention significantly improves survival outcomes in both genders. Gender, along with age, grade, TNM stage, surgery, and mitotic rate, serves as a predictive indicator for survival […]
Improved Patient Outcomes with SPARC Collaboration
Establishing the SPARC program led to improved patient outcomes for retroperitoneal sarcoma at RPAAH and COBLH. The program saw an increase in operations from 15 to 35 cases annually, with liposarcomas and leiomyosarcomas being the most common types resected. The majority of cases underwent extended resections, resulting in a high rate of R0/R1 resections. Collaboration, […]
Comparable Long-Term Survival Prognoses in Gastrointestinal Neuroendocrine Neoplasms
Endoscopic treatment and surgery show similar overall and cancer-specific survival rates in gastrointestinal neuroendocrine neoplasms. Endoscopic treatment may offer a better cancer-specific survival in certain cases such as stage I tumors and those smaller than 10mm. Both treatment options are viable for patients, with endoscopic treatment as a potential alternative for those hesitant about surgery. […]
Similar Long-Term Survival in MIS for Ileal NETs
Minimally invasive surgery (MIS) shows comparable long-term survival outcomes to open surgery for ileal neuroendocrine tumors (i-NETs), with no significant difference in overall survival rates at around 99 to 103 months follow-up. MIS is a viable alternative for i-NETs resection, especially in cases without bulky mesenteric masses or concurrent liver resections. The study suggests MIS […]
Multidisciplinary Approach Boosts Surgical Outcomes for Retroperitoneal Sarcomas in India
Establishing a dedicated multidisciplinary tumor board significantly improved surgical outcomes for retroperitoneal sarcoma patients. The post-clinic era saw a marked increase in annual surgeries from 16.3 to 42.4 (p = 0.001), and a rise in complex resections (49% vs. 18.2%; p = 0.0001). These changes underscore the importance of standardized management protocols and collaborative care […]