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A retrospective study of 384 patients undergoing surgery for non-functioning pancreatic neuroendocrine tumours revealed that 40% received potentially inadequate treatment. Of these, 34% experienced potential overtreatment while 6% were potentially undertreated. Key predictors of overtreatment included smaller tumour sizes and earlier surgical intervention, while larger…
The review highlights the evolving role of endoscopic ultrasound (EUS) in managing pancreatic neuroendocrine tumors (PanNETs), addressing their increasing incidence and associated diagnostic and therapeutic challenges. EUS has advanced from solely a diagnostic tool to facilitating minimally invasive locoregional therapies. Surgical intervention remains paramount, especially…
Subgrading G2 pancreatic neuroendocrine tumors into 2A (Ki67 3% to < 10%) and 2B (10% to ≤ 20%) identifies distinct subsets with different metastasis rates and aggressiveness. G2B cases show significantly higher rates of liver/distant metastasis, lymph node metastasis, and histopathologic signs of aggressiveness compared…
Larger tumor size and elevated serum chromogranin A levels are predictive of metastatic disease in patients with gastroenteropancreatic neuroendocrine tumors undergoing DOTATATE imaging. Patients with primary tumor size ≥2 cm, serum CGA level ≥150 ng/ml, and tumor grade g2 are at higher risk of metastases,…
Minimally invasive surgery for gastric gastrointestinal stromal tumour (GIST) resections showed increased utilization and improved perioperative outcomes over time. Complication rates decreased, duration of admission and operating time shortened, while the composite measure of textbook outcome (TO) increased. Minimally invasive surgery was associated with fewer…
In metastatic Grade 1 gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), a higher burden of liver disease significantly reduces progression-free survival (PFS). Patients with concomitant extra-hepatic involvement have a lower overall survival (OS) rate. Liver tumor burden emerged as the sole predictor of PFS. These findings suggest a…
Endoscopic ultrasonography (EUS) is a sensitive method for identifying residual rectal neuroendocrine tumors (NETs) post-resection. EUS detection, with a high sensitivity of 94%, is superior to visual detection. Salvage endoscopic treatment, incorporating EUS, is safe and effective in managing incompletely resected NETs, with no recurrence…
Minimally invasive surgery for left pancreatic resection in patients with resectable pancreatic neuroendocrine tumors reduces major complications and offers comparable long-term oncologic outcomes. A study comparing minimally invasive and open surgery showed lower rates of major morbidity, postoperative complications, and better outcomes with minimally invasive…
Male patients with small intestinal stromal tumors (SISTs) have a higher risk of mortality compared to females. Females exhibit superior overall survival and cancer-specific survival rates than males. Surgical intervention significantly improves survival outcomes in both genders. Gender, along with age, grade, TNM stage, surgery,…
Establishing the SPARC program led to improved patient outcomes for retroperitoneal sarcoma at RPAAH and COBLH. The program saw an increase in operations from 15 to 35 cases annually, with liposarcomas and leiomyosarcomas being the most common types resected. The majority of cases underwent extended…
