Peptide receptor radionuclide therapy (PRRT) significantly improves progression-free survival (PFS) and overall survival (OS) in patients with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who progress after surgical resection. Among 237 analyzed patients, those receiving PRRT experienced a median PFS of 32.4 months compared to 11.0 months for those who did not (p < 0.001). Median OS […]
Category: Sarcoma & rare tumors
Endoscopic ultrasonography-guided ethanol injections demonstrate efficacy for small pancreatic tumors
A prospective multicenter study evaluated endoscopic ultrasonography-guided ethanol injections (EUS-EI) for treating small pancreatic neuroendocrine neoplasms (PNENs). Of the 25 patients treated, 76% achieved the primary endpoint compared to surgical outcomes, and 88% attained complete ablation at 1 and 6 months. Safety results were promising, with 96% experiencing no severe adverse events within one month. […]
Mural nodules and intraluminal air predict neuroendocrine tumors.
Mural nodules protruding into the lumen and intraluminal air serve as significant predictors of neuroendocrine tumors in patients with acute appendicitis. In a study involving 1,150 patients, those with neuroendocrine tumors exhibited a mural nodule prevalence of 53.3% sensitivity and 95.8% specificity, while intraluminal air showed 53.3% sensitivity and 76.7% specificity. Incorporating these imaging indicators […]
New tool predicts liver metastasis risks in neuroendocrine tumors
A novel Liver Metastasis Score (LMS) effectively predicts liver metastasis risk for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) post-surgery. Among 724 patients studied, 9.1% developed liver metastasis, significantly impacting survival rates (63.6% vs. 95.8% for no metastasis). Key risk factors identified include Ki-67 index, vascular invasion, lymph node metastases, and absence of adjuvant therapy. The […]
Machine learning model predicts malignant potential of gastric tumors
A novel machine-learning model effectively predicts the malignant potential of gastric gastrointestinal stromal tumors (GISTs), identifying key risk factors such as endoscopic ultrasound features, tumor margin clarity, diameter, and monocyte-to-lymphocyte ratio. Tested with 318 patients, the logistic classification model achieved high performance with area under the curve values of 0.919 and 0.925 for training and […]
High preoperative HbA1c levels correlate with poorer outcomes in GEP-NET patients
Higher preoperative glycosylated hemoglobin A1C (HbA1c) levels significantly affect long-term outcomes in patients undergoing resection for nonfunctional gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A study involving 190 patients revealed that those with HbA1c ≥ 6.5% experienced increased complications and markedly reduced median overall survival (89.8 months vs. not reached for low HbA1c). This association highlights the need […]
Surgery improves outcomes in metastatic neuroendocrine tumors
Evidence suggests that surgical intervention, prior to peptide receptor radionuclide therapy, significantly enhances progression-free survival for patients with metastatic gastroenteropancreatic neuroendocrine tumors. In a study of 89 well-matched patients, those who underwent surgery had a median progression-free survival of 26.1 months, compared to 15.6 months in the no-surgery group (p = .04). Furthermore, liver debulking […]
EUS-FNA/B shows strong diagnostic performance for PANNETs
A meta-analysis involving 2,978 patients confirms that endoscopic ultrasound-guided fine needle acquisition (EUS-FNA/B) is an effective method for diagnosing and pre-operatively grading pancreatic neuroendocrine tumors (PANNETs). The overall concordance rate with surgical grading was 0.77, with a notable increase in the G1 subgroup (0.88). Notably, fine needle biopsy (FNB) outperformed fine needle aspiration (FNA) in […]
Wide hot snare polypectomy outperforms other methods for small tumors
In a study assessing salvage treatments for rectal neuroendocrine tumors (RNETs) under 10 mm, wide hot snare polypectomy (WHSP) showed superior outcomes. Of 121 patients analyzed, WHSP achieved an impressive 72.7% R0 resection rate compared to other methods. With a focus on effectiveness and safety, WHSP emerged as a rapid and straightforward approach for these […]
Inadequate surgical treatment affects non-functioning pancreatic neuroendocrine tumours.
A retrospective study of 384 patients undergoing surgery for non-functioning pancreatic neuroendocrine tumours revealed that 40% received potentially inadequate treatment. Of these, 34% experienced potential overtreatment while 6% were potentially undertreated. Key predictors of overtreatment included smaller tumour sizes and earlier surgical intervention, while larger tumour diameter indicated potential undertreatment. Patients facing undertreatment exhibited significantly […]