A systematic review was conducted to assess the presentation, diagnosis, optimal surgical approach, and post-operative outcomes of abdominal catastrophes secondary to intestinal lymphomas. A total of 95 patients were identified, with Burkitt’s lymphoma and diffuse large B-cell lymphoma being the most common types. Small bowel resections had a 25% complication rate and a 13.8% 30-day […]
Category: Sarcoma & rare tumors
Classification of GIST and Other Benign Gastric Tumors for Minimally Invasive Surgery
The study aimed to propose a new surgical classification for non-malignant gastrointestinal mesenchymal tumors (GMTs) based on their location and guide minimally invasive surgical strategies. The classification divided the tumors into two groups (exophytic and transmural/intragastric) and further subdivided them based on location. The study included 42 patients distributed into each subgroup. Encouraging perioperative outcomes […]
Management and Prognosis of Gastric Neuroendocrine Tumors
Gastric neuroendocrine tumors (G-NETs) are rare tumors originating from the gastric mucosa, classified into three subtypes based on their characteristics and behavior. Type 1 and 2 are typically multifocal and associated with elevated serum gastrin levels. Type 2 causes symptoms like abdominal pain and diarrhea. Type 3, sporadic and solitary, has the most aggressive phenotype. […]
Primary tumor resection does not impact event-free survival in patients with metastatic small bowel neuroendocrine tumors
The study investigated the impact of primary tumor resection on the development of disease-specific complications in patients with metastatic well-differentiated small bowel neuroendocrine tumors (SBNETs). The retrospective analysis of 180 patients showed that rates of event-free survival did not differ based on primary tumor management. Patients who underwent medical management first had a 23% complication […]
Advancements in the treatment of soft tissue sarcomas: A comprehensive update
Emerging innovations and advancements in the treatment of extremity and truncal soft tissue sarcomas are explored in this special edition update. The study covers classifications, emerging technologies, prognostic tools, radiation schemas, and treatment disparities. The results emphasize the importance of enhancing local control and reducing complications through innovative imaging, surgical guidance, and hypofractionated radiation. Additionally, […]
Surgical Principles for Small Bowel Neuroendocrine Tumor Resection
Small bowel neuroendocrine tumors (SB-NETs) are increasingly identified and have become the most frequent entity among small bowel tumors. Surgical treatment goals include control of tumor volume, endocrine secretion, and prevention of locoregional complications. The study presents eight steps for systematic surgical planning and execution of resection. The role of primary tumor resection in the […]
Optimal Surgical Approach for Small Bowel Neuroendocrine Tumors
In addressing the surge in small bowel neuroendocrine tumors (SB-NETs), this study underscores surgery’s pivotal role. Emphasizing multifocal assessment and mesenteric-sparing strategies, it delineates eight systematic steps for surgical planning. While stressing the necessity of achieving oncological control, some controversies persist, notably regarding resection in the presence of liver metastasis. The study encourages SB-NET resection […]
DNA Methylation Classifier Illuminates Sarcoma Diagnoses and Molecular Markers
Researchers evaluated a sarcoma DNA methylation classifier for soft tissue and bone tumors, including 619 cases. The classifier exhibited high sensitivity and specificity for fusion sarcomas (Ewing, synovial, cic-rearranged, bcor-rearranged), leiomyosarcoma, MPNST, and malignant vascular tumors. However, sensitivity was low for desmoid fibromatosis, neurofibroma, and schwannoma, with low specificity for certain diagnoses. MDM2 amplification and […]
Unlocking Hope for Neuroendocrine Carcinomas: Spheroid Screening Points to DNA Repair Inhibitors
In the quest for effective gastroenteropancreatic neuroendocrine carcinoma treatments, researchers unleashed patient-derived tumor spheroids. A dazzling 16 compounds, notably tyrosyl-DNA phosphodiesterase 1 inhibitors, emerged as fierce warriors against over 75% of these rare tumors. Cytarabine, a standout from the bunch, synergized with standard drugs, intensifying the battle against cancer cells. These findings spotlight a promising […]
Laparoscopic Showdown: Transperitoneal Triumphs in Tackling Retroperitoneal Tumors
Researchers delved into the battle of surgical approaches for benign retroperitoneal tumors (BRTs). Analyzing data from 43 patients, the laparoscopic transperitoneal approach emerged as the superhero, boasting lower conversion rates and comparable outcomes to its retroperitoneal counterpart. With enhanced visual perspectives and bleeding control, the transperitoneal technique flexed its anatomical advantages, proving especially potent against […]