Researchers analyzed a large number of tissue samples and found that gad2 immunohistochemistry is a highly specific diagnostic marker for neuroendocrine neoplasms of the pancreas. The expression of gad2 was only observed in a few normal cell types, making it a potential diagnostic tool. It was found to be most commonly seen in neuroendocrine carcinomas […]
Category: Sarcoma & rare tumors
Portal Vein Resection in Pancreatic Neuroendocrine Neoplasms
Portal vein resection in surgery for pancreatic neuroendocrine neoplasms was analyzed in this study. Among 666 patients, 8% underwent portal vein resection. Postoperative complications were comparable to standard resection, with a low 90-day mortality rate. Radical resection resulted in excellent 5-year overall and disease-specific survival rates. This study provides valuable data on the perioperative and […]
Nomogram Combined Treatment Data is More Effective than AJCC Staging System for Predicting Overall Survival in GEP-NETs
Researchers conducted a study to develop and validate a nomogram for predicting overall survival (OS) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Using data from the SEER registry, they identified key prognostic factors and compared the nomogram’s performance to the AJCC staging system. The results showed that the nomogram, which combined treatment data, had a […]
Netosis in Surgery: Implications, Impact, and Potential Treatments for Surgeons
Netosis, the formation of neutrophil extracellular traps (NETs), is a novel function of neutrophils. These NETs play a crucial role in trapping microorganisms and preventing their spread throughout the body. However, they can also lead to tissue damage and contribute to various diseases like gallstone formation, acute pancreatitis, impaired wound healing, intravascular coagulation, cancer growth, […]
Minimally Invasive Surgery Shows Promise for Small Intestinal Neuroendocrine Neoplasms
A retrospective study compared minimally invasive (MIS) and open surgery for treating small intestinal neuroendocrine neoplasms. Out of 65 patients, 54% underwent MIS and 46% underwent open surgery. The study found no significant difference in the frequency of successful resections or the number of lymph nodes removed between the two groups. However, a post-operative paralytic […]
Surgical Management Guidelines for Gastrointestinal Neuroendocrine Neoplasms Provide Individualized Approach
Surgical oncologists face the challenge of managing gastrointestinal midgut neuroendocrine neoplasms (NENs), particularly neuroendocrine tumors (NETs). While guidelines offer valuable insights, they rely on expert opinions and retrospective evidence. This review outlines recent recommendations for managing midgut NETs, emphasizing the need for individualized approaches based on tumor behavior, endocrine syndrome association, and prognosis. Staying updated […]
Endoscopic Resection Shows Promising Results in Treating Gastric Gastrointestinal Stromal Tumors
Endoscopic resection (ER) has shown to be an effective and safe method for treating gastric gastrointestinal stromal tumors (GISTs), as suggested by a retrospective study in a large tertiary hospital in China. With a sample size of over 300 patients and a follow-up period longer than 45 months, the study found an en bloc resection […]
Frequent Surveillance Imaging for Low-Risk Gastrointestinal Stromal Tumors Yields Little and Incurs High Costs
This study assessed the utility and costs of surveillance imaging for low- and very low-risk gastrointestinal stromal tumors. The researchers reviewed the surveillance strategy in 60 patients and found that frequent imaging studies were performed with little yield and at substantial cost. No recurrences were detected, and the mean number of surveillance images per patient […]
Optimal Surgical Management and Outcomes of Abdominal Catastrophes Secondary to Intestinal Lymphomas
A systematic review was conducted to assess the presentation, diagnosis, optimal surgical approach, and post-operative outcomes of abdominal catastrophes secondary to intestinal lymphomas. A total of 95 patients were identified, with Burkitt’s lymphoma and diffuse large B-cell lymphoma being the most common types. Small bowel resections had a 25% complication rate and a 13.8% 30-day […]
Classification of GIST and Other Benign Gastric Tumors for Minimally Invasive Surgery
The study aimed to propose a new surgical classification for non-malignant gastrointestinal mesenchymal tumors (GMTs) based on their location and guide minimally invasive surgical strategies. The classification divided the tumors into two groups (exophytic and transmural/intragastric) and further subdivided them based on location. The study included 42 patients distributed into each subgroup. Encouraging perioperative outcomes […]