Newsletter
Best Papers in General Surgery
The five that matter, every day.
A new clinical prediction model offers reliable assessment for anastomotic leakage (AL) in rectal cancer surgery, based on a study of 3,765 patients. The model identified key risk factors, including gender, diabetes, preoperative chemoradiotherapy, and surgical parameters. With area under the curve (AUC) values of…
A meta-analysis involving 9,516 patients found that all surgical procedures for gastroesophageal reflux disease (GERD) significantly improved post-operative outcomes. Nissen fundoplication outperformed transoral incisionless fundoplication in reducing acid exposure and Demeester scores. However, Toupet fundoplication and magnetic sphincter augmentation provided superior symptom relief compared to…
Gastrointestinal motility agents significantly enhance recovery in patients after elective colorectal surgery, according to a systematic analysis of seven randomized controlled trials involving 849 individuals. Patients experienced accelerated gastrointestinal recovery by 1.01 days and reduced time to first bowel movement by 1.07 days. Importantly, safety…
A recent study identified ten key genes associated with colorectal cancer (CRC) stemness, revealing their correlation with disease-free and progression-free survival. Using a machine learning model, researchers found that higher mRNA expression-based stemness indexes (mrnasi) correlated with improved clinical outcomes. Notably, CRC samples with lower…
A newly developed nomogram effectively predicts the risk of primary liver cancer (PLC) in patients with liver cysts, integrating CT imaging features and alpha-fetoprotein (AFP) levels. In a study involving 122 participants, higher AFP levels and specific CT characteristics were linked to PLC occurrence. The…
Current findings highlight the efficacy of bariatric surgery in treating metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to steatohepatitis. The surgical interventions, including Roux-en-Y gastric bypass and sleeve gastrectomy, significantly enhance liver outcomes by reducing steatosis, inflammation, and fibrosis, while lowering cancer risk.…
A study involving 292 patients undergoing major liver surgery revealed that the hepatic uptake index (hui) derived from gadoxetic acid-enhanced MRI outperformed traditional volume-only assessments in identifying those at risk for severe post-hepatectomy liver failure (phlf). Among the cohort, 8.6% developed severe phlf, with affected…
A phase II clinical trial demonstrates the feasibility of mass-based response testing (MRT) in tailoring intraperitoneal chemotherapy for patients with unresectable appendiceal or colorectal peritoneal metastases. MRT assessed tumor susceptibility to various HIPEC drug regimens, offering a personalized approach to treatment. The study aims to…
Research highlights two molecular subtypes of gastric cancer, revealing that the stemness subtype substantially increases the risk of hematogenous metastasis (HM). Through analyses of bulk-rna sequencing from 64 samples and a patient-derived xenograft model, the study identified 10 stemness signature genes. These genes helped stratify…
A newly established colorectal cancer-specific tertiary lymphoid structures (TLS) signature correlates with enhanced overall survival and treatment responses in patients. In the TCGA cohort, those with high TLS scores showed significantly longer survival (p=0.008) and greater complete or partial response rates (p=0.017). The study also…
