Newsletter
Best Papers in General Surgery
The five that matter, every day.
Immunologically cold tumors pose challenges for effective cancer treatment due to low immune infiltration. Therapeutic cancer vaccines, which deliver high-quality tumor-specific antigens, are being investigated in various clinical contexts to boost immune responses and improve patient outcomes. Despite the potential, challenges in antigen selection, vaccine…
A study involving 582 patients established and validated a cut-off value of 0.268 for the Roberts Score, demonstrating its effectiveness in predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after Pancreaticoduodenectomy. The area under the curve (AUC) reached 0.768 in the exploratory cohort. Higher Roberts Scores…
Laparoscopic ileostomy reversal significantly decreases postoperative complications compared to open surgery, lowering overall complication rates (OR=0.40). It notably reduces risks of bowel obstruction and wound infection, while requiring longer operative time. However, it facilitates shorter hospital stays without increasing blood loss. An analysis of 867…
Evidence synthesized from various databases reveals that postoperative nausea and vomiting (PONV) are prevalent complications following surgeries with anesthesia, causing significant discomfort. The review identifies intricate neural mechanisms and signaling pathways that contribute to PONV, emphasizing the interaction of multiple pathways rather than independent functions.…
A prospective audit of 655 surgical antibiotic prescriptions revealed that only 49% adhered to guidelines, with significant issues such as inappropriate selections and prolonged usage. Community-acquired infections constituted 89% of treatments. The audit highlighted a low antibiotic guideline compliance rate and identified reasons for non-compliance.…
Gastric cancer poses a significant global health challenge, with nearly 1 million new cases and over 650,000 deaths annually. The disease shows geographical disparities and a troubling rise in early-onset cases among those under 50. Key risk factors include H. pylori infection and unhealthy lifestyles.…
Significant advancements in treating unresectable hepatocellular carcinoma (HCC) have emerged, particularly with immune checkpoint inhibitor (ICI) combinations that increase median survival to over two years, with some patients exceeding five years. Despite this, recent studies found no improvement in recurrence-free survival with adjuvant ICI therapy.…
A study of 649 hepatocellular carcinoma (HCC) patients revealed that those with triple positive tumor markers experienced significantly improved recurrence-free survival when receiving postoperative adjuvant therapy (30.0 months) compared to those who did not (19.6 months, p=0.019). The analysis also showed that the number of…
A systematic review and meta-analysis revealed that arterial and anastomotic wrapping significantly decreases major complications in pancreaticoduodenectomy. Specifically, researchers noted a reduction in postpancreatectomy hemorrhage (OR 0.47; p < 0.001) and postoperative pancreatic fistula with omental wrapping (OR 0.48; p = 0.002). The technique did…
A study of 1,504 patients with hepatocellular carcinoma revealed that a low skeletal muscle index/systemic immune-inflammation index (SMI/SII) ratio is a significant independent prognostic factor for poor overall survival (OS). Results showed the high SMI/SII group had a notably better OS compared to the low…
