Newsletter
Best Papers in General Surgery
The five that matter, every day.
Analysis of 232,155 colectomy cases revealed that stapling anastomosis (SA) is favored over hand-sewn anastomosis (HA), with usage rising from 80% in 2015 to 85% in 2021. The study, using propensity score matching, indicated a higher reoperation risk in the HA group (1.27%) compared to…
A multicenter study of 7,303 patients revealed that octogenarians undergoing laparoscopic or robot-assisted colorectal surgeries exhibit significantly higher postoperative complication rates compared to younger counterparts. Specifically, patients aged 80 and above had increased comorbidities and elevated ASA and ECOG-PS scores, indicating greater surgical risks. Findings…
Food insecurity in surgical trauma patients correlates with significantly higher complication rates (41.4% vs. 12.5%) and longer hospital stays (median of 13 days vs. 5 days). Among 848 patients, 21% reported food insecurity prior to surgery, with those becoming food insecure postoperatively also facing greater…
The 2024 IHPBA Legacy Initiative targets hepatocellular carcinoma (HCC) in sub-Saharan Africa, addressing significant healthcare challenges due to high incidence rates and inadequate infrastructure. It focuses on enhancing management pathways and access to care through a multidisciplinary approach, including prevention, early diagnosis, and treatment strategies.…
In a systematic review of eight studies involving 6,648 patients, robotic pancreaticoduodenectomy (RPD) demonstrated significant advantages over laparoscopic pancreaticoduodenectomy (LPD) for malignant lesions. Key findings included a reduced length of hospitalization (mean difference of -0.94 days), lower conversion rates (odds ratio of 0.20), and a…
Single-cell analyses reveal significant insights into lymph node metastasis in intrahepatic cholangiocarcinoma (ICCA). A complex heterogeneity was identified within the lymph node microenvironment, with an increase in stromal and mature immune cells, particularly diverse T cell subtypes. Notably, CD36+ macrophages and SAA1+ tumor cells were…
A nationwide study covering Denmark from 1996 to 2020 evaluated 33,951 patients with chronic diverticular disease and found a 5-year cumulative incidence of surgical intervention at 13.9%—9.8% elective and 4.2% emergency. Complicated cases presented a three- to six-fold increased likelihood of surgery compared to uncomplicated…
A new predictive model significantly enhances the accuracy of forecasting 5-year recurrence rates in hepatocellular carcinoma (HCC) patients post-surgery. Integrating LASSO regression and random forest techniques, the model identified six key factors, achieving an area under the curve (AUC) of 0.733, compared to the initial…
Patients undergoing surgeries immediately before the weekend face higher risks of death, readmission, and complications compared to those treated afterwards. An analysis of over 429,000 patients in Ontario revealed a consistent increase in adverse outcomes at 30 days, 90 days, and one year post-surgery for…
A 65-year-old man with unresectable, microsatellite-high intrahepatic cholangiocarcinoma experienced significant tumor shrinkage after receiving pembrolizumab, following a failed combination therapy. The comprehensive cancer genomic profiling identified an mlh1 pathogenic mutation, suggesting the microsatellite instability was somatic rather than inherited. Remarkably, the response was maintained for…
