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Best Papers in General Surgery
The five that matter, every day.
A multicenter retrospective study evaluated neoadjuvant immunochemotherapy involving PD-1 agents plus platinum-based chemotherapy for 213 patients with resectable esophageal cancer. The study reported a high pathological complete response (PCR) rate of 31.9%, with a complete tumor resection (R0) rate of 99.1%. Additionally, two-year disease-free survival…
A study involving 584 acute biliary pancreatitis patients revealed that age, gamma-glutamyl transferase, alkaline phosphatase, and direct bilirubin levels significantly correlate with choledocholithiasis presence. The determined cut-off values indicated a 97% negative predictive value for a clean common bile duct when all four parameters were…
Laparoscopic portal territory fluorescence navigation-guided anatomical liver resection (LPTAR) outperforms classic anatomical resection (CAR) for hepatocellular carcinoma (HCC) patients. In a study of 234 patients, those undergoing LPTAR demonstrated significantly wider resection margins, reduced blood loss, and fewer postoperative complications compared to CAR. Furthermore, the…
In a multicenter study, significant differences in long-term survival were observed between patients with Epstein-Barr virus-associated gastric cancer (EBVAGC) and those with Epstein-Barr virus-negative gastric cancer (EBVNGC) after radical gastrectomy. The 3-year overall and disease-free survival rates were notably higher in the EBVAGC group. Additionally,…
A recent systematic review and meta-analysis of 31 studies involving 17,968 participants demonstrated that triclosan-containing sutures substantially lower the incidence of surgical site infections compared to non-triclosan sutures, achieving a relative risk of 0.75 (95% CI, 0.65-0.86). Despite moderate certainty due to heterogeneity, the trial…
This systematic review and meta-analysis involving 39,499 participants reveals that smokers who stopped smoking at least four weeks prior to cancer surgery experience significantly fewer complications. Those who smoked within four weeks before surgery faced 31% higher odds of complications, while those who never smoked…
Laparoscopic cholecystectomy via the supraumbilical port significantly decreased postoperative pain compared to the subxiphoid port. In a study of 253 patients, the supraumbilical group reported lower worst pain ratings (4.24 vs. 4.91) and milder pain on the third day (3.35 vs. 3.75). Pain affected general…
A multicentre study involving 1,649 patients assessed malnutrition risk in major abdominal surgeries. The Subjective Global Assessment (SGA) identified 34.1% as malnourished, while various tools showed significant variability in assessments. The Malnutrition Universal Screening Tool (MUST) and Mini Nutrition Assessment Short Form (MNA-SF) exhibited the…
Significant advancements in endoscopic techniques for managing malignant biliary and gastric outlet obstruction in pancreatic cancer patients provide promising alternatives to traditional surgical bypass. Emerging evidence suggests that endoscopic ultrasound-guided methods, including biliary drainage and gastroenterostomy, may outperform conventional approaches, addressing symptom relief more effectively.…
The study analyzed treatment outcomes for hepatocellular carcinoma (HCC) related to newly established oncological resectability criteria. Results showed median survival times were 107.2 months for resectable (R) patients, 44.4 months for BR1, and only 18.4 months for BR2 patients. The data indicate that these criteria…
