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Best Papers in General Surgery
The five that matter, every day.
A systematic review and network meta-analysis identified eight effective interventions for preventing postoperative esophageal stenosis following endoscopic resection of superficial cancer. Notable approaches included the combination of polyglycolic acid with a steroid and botulinum toxin. These interventions also led to significant reductions in the number…
In a comparative study of 59 patients with metachronous colorectal cancer, laparoscopic surgery demonstrated significant advantages over open surgery. Patients who underwent laparoscopic procedures experienced less blood loss (56.80 ml vs. 136.47 ml), faster recovery of bowel function, and shorter hospital stays (7.24 days vs.…
Analysis reveals a strong correlation between tumor-stroma ratio (tsr) and peritoneal metastasis (pm) in gastric cancer patients. The study included 640 patients across several cohorts, establishing a diagnostic model integrating tsr with CA125, CA724, and Borrmann type. The model demonstrated robust predictive capabilities, achieving an…
In a study involving 1,115 patients with mid-low rectal cancer, transanal total mesorectal excision (TME) demonstrated a 3-year disease-free survival rate of 82.1%, while laparoscopic TME showed 79.4%, indicating noninferiority. The local recurrence rates were 3.6% and 4.4%, respectively. Additionally, overall survival rates were 92.6%…
Over a 40-year analysis involving 5,070 patients, significant differences in pouch survival rates were observed among various diagnoses. Ulcerative colitis (UC) had a 20-year survival rate of 92%, while Crohn's disease (CD) was lower at 87%. Patients with familial adenomatous polyposis (FAP) exhibited the best…
Between 1990 and 2021, gallbladder and biliary tract cancer (GBTC) saw a substantial increase, with new cases rising by 101.09% and deaths by 74.26%. In 2021, there were approximately 216,768 new cases and 171,961 deaths globally, predominantly affecting females and older adults. Although age-standardized incidence…
Preoperative circulating tumor DNA (ctDNA) analysis shows significant prognostic value in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemotherapy followed by surgery. Among 25 patients, those with ctDNA detected post-treatment faced a recurrence-free survival rate of only 8% at 36 months, compared to…
Over the past 20 years, an analysis of 182 randomized controlled trials (RCTs) on gastroesophageal reflux disease and hiatal hernia highlighted that over 86.7% exhibited significant research waste. The majority of trials were drug-related, primarily conducted in North America and Asia, with deficiencies found in…
A study of seventy patients undergoing EUS-guided drainage revealed that 35.7% required step-up procedures, mainly endoscopic necrosectomy. Independent predictors included necrosis ≥60% and classification in the high-risk Quadrant Necrosis Infection (QNI) group. Clinical success was high, at 92.9%, with those in the high-risk group experiencing…
Clustering preoperative tumor marker patterns aids in predicting surgical outcomes for patients with peritoneal metastases. Among 138 with pseudomyxoma peritonei (pMP), two distinct clusters emerged—pMP cluster-1 had a 5-year overall survival rate of 77%, while pMP cluster-2 faced a significantly poorer prognosis of 36%. A…
