Newsletter
Best Papers in General Surgery
The five that matter, every day.
A novel approach to matching patients with pancreatic ductal adenocarcinoma (PDAC) to effective chemotherapy has shown significant promise. Patient-derived organoids (PDOs) matched 91% of patients to standard treatments, improving CA 19-9 markers and lymph node staging. Notably, those who received therapies well-aligned with their PDO…
A novel approach to robot-assisted cervical esophagectomy combining cervical and abdominal procedures has shown significant advantages. In a study of 30 patients, this simultaneous procedure, utilizing nerve integrity monitoring without muscle relaxants, resulted in a total operative time of 291.2 minutes, markedly shorter than the…
An analysis of 170 patients with acute cholecystitis revealed that 37.1% had gallbladder perforation, correlated with higher rates of complications. Key biomarkers, including C-reactive protein (CRP) and the CRP/albumin ratio (CAR), demonstrated significant differences between perforated and non-perforated cases. Despite their low specificity and sensitivity,…
Implementation of enhanced recovery after surgery (ERAS) protocols at 15 Ontario hospitals resulted in a significant 1.05-day reduction in length of stay (13.7%) for colorectal surgeries. Notably, left-sided colorectal surgeries saw an even greater decrease of 1.17 days (15.6%). This reduction remained consistent over time…
Stool-based surveillance strategies may safely decrease colonoscopy demand by 15-41% following polypectomy, according to the MOCCAS study. Conducted on 3,453 individuals, the study demonstrated that multitarget stool DNA tests and fecal immunochemical tests (FIT) were effective alternatives, especially for those at lower risk. Long-term simulations…
A multicenter analysis demonstrates that Endoscopic Vacuum Therapy (EVT) has a high success rate for treating Boerhaave's syndrome, yielding an 80% treatment success in 25 patients. Mortality rates were significantly lower for EVT patients (8.0%) compared to those undergoing other methods (25.0%). Moreover, treatment success…
Patients undergoing minimally invasive distal pancreatectomy without abdominal drains experienced significantly lower rates of postoperative pancreatic fistula (3.4% vs. 27.6%) and abdominal collections (3.4% vs. 31.0%), along with a shorter hospital stay (5 days vs. 9 days). These findings suggest that not using drains during…
A study reviewing 56 cases presented at the novel benign liver and pancreas rounds highlights the effectiveness of a multidisciplinary case conference in managing benign hepatopancreatobiliary diseases. The discussions resulted in a change or adjustment in the proposed management plan for 82% of cases, with…
A systematic review and meta-analysis involving 9,352 patients reveals that endoscopic submucosal dissection (ESD) outperforms endoscopic mucosal resection (EMR) in effectively treating early Barrett's neoplasia. ESD achieved significantly higher en-bloc resection rates (odds ratio 25.96) but was associated with greater incidence of adverse events. The…
A multicenter study involving 1,601 patients revealed a 13.5% incidence of lymph node metastasis (lnm) in early esophago-gastric adenocarcinoma. Factors such as tumor depth and lymphovascular invasion showed initial associations with lnm but lacked significance in multivariable analyses. Notably, surgery following endoscopic resection significantly improved…
