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Best Papers in General Surgery
The five that matter, every day.
A systematic review and meta-analysis of six randomized clinical trials involving 509 patients evaluated the effects of enhanced recovery after surgery (ERAS) protocols following emergency laparotomy. Findings indicated that ERAS significantly reduced postoperative nausea and vomiting (odds ratio: 0.32), time to ambulation (mean difference: 1.67…
Key findings indicate that flattening of marginal tumor swelling is a strong independent predictor of pathological complete response (PCR) in rectal cancer patients post-neoadjuvant therapy (p < 0.001, odds ratio = 100.605). Additionally, lower preoperative carcinoembryonic antigen and erythrocyte sedimentation rates also correlate with PCR,…
A narrative review highlights key opportunities to improve peri-operative care, emphasizing timely alternative treatments to reduce unnecessary surgeries. Risk assessment during surgical listing is crucial for optimizing comorbidities. Enhanced recovery after surgery (ERAS) protocols lead to fewer complications and shorter hospital stays but require clinician…
The integration of the "Robotic Curriculum for young Surgeons" (RoCS) into clinical practice did not compromise patient outcomes, according to a comparative study of two cohorts. Key results demonstrated no significant differences in in-hospital, 30-, or 90-day morbidity and mortality rates between groups. Surgical efficiency…
The study reviewed the increasing integration of the Clavien-Dindo Classification (CDC) and Comprehensive Complication Index (CCI®) in 1,327 randomized controlled trials (RCTs), revealing a rise of over 200 new RCTs annually. However, only one-third of the published RCTs included the entire CDC grading scale. A…
Findings indicate that the explanatory power of trauma mortality models decreases linearly with age, significantly affecting objective comparisons of outcomes. Among 317,136 patients analyzed, the relative utility of covariates like Glasgow Coma Scale and Injury Severity Score varies across age groups, highlighting limitations in current…
Analysis of 26 studies involving 6456 hepatocellular carcinoma (HCC) patients demonstrated that hepatic artery infusion chemotherapy (HAIC) consistently outperformed Sorafenib in overall survival (OS) outcomes, except for those refractory to trans-arterial chemoembolization. Key risk factors for reduced OS included larger tumor size and heavier tumor…
A retrospective analysis of 111 pancreatic cancer patients undergoing pancreaticoduodenectomy revealed that 62.2% achieved textbook outcomes, significantly improving overall survival (OS) [p=0.03; HR=0.60]. Cox regression identified achievement of these outcomes as a protective factor for OS [p=0.04; HR=4.08]. Key barriers to achieving textbook outcomes included…
Gene expression analysis revealed 236 common differentially expressed genes (DEGs) between COVID-19 and pancreatic cancer (PC) patients. Functional enrichment pointed to pathways linked to viral replication and tumorigenesis. Ten hub genes, including cyclin-dependent kinase 1 and aurora kinase B, were identified, along with 42 transcription…
