Patient-derived organoids (PDOs) from EUS-guided biopsies show high success rate in establishing models for pancreatic ductal adenocarcinoma (PDAC). PDAC PDOs accurately reflect genetic alterations in the original tumors and predict drug sensitivity, including resistance to nab-paclitaxel. This innovative model enables rapid testing of multiple therapeutic drugs, offering a personalized “patient avatar” for timely clinical decision-making […]
Category: General Surgery
Polymerase Chain Reaction for Detecting Bacteria in Peritoneal Fluid
Polymerase chain reaction accurately detects bacteria in peritoneal fluid, guiding postoperative antibiotic treatment in patients with acute appendicitis. Results show concordance of 71.4% between PCR and conventional culture, with Escherichia coli and Bacteroides fragilis being the most common bacteria. Study highlights PCR’s potential in diagnosing bacterial infections, even in cases where conventional culture fails to […]
Enhanced Gastric Cancer Staging Using New N Classification System
This study developed and validated a new lymph nodal staging system for pt3-4n0-2m0 gastric cancer patients. The new classification, based on examined lymph nodes and lymph node ratio, outperformed the current system in prognostic prediction accuracy. The improved staging method emerged as an independent prognostic indicator, providing enhanced survival analysis for patients. Surgeons are encouraged […]
Beneficial outcomes of total pancreatectomy with islet autotransplantation in genetic pancreatitis
Total pancreatectomy with islet autotransplantation (TPIAT) provides beneficial metabolic and pain relief outcomes in patients with genetic chronic pancreatitis. Patients with genetic etiology undergo TPIAT at a younger age, experience longer symptom duration, and yield lower islet mass, yet maintain similar metabolic function post-transplant. Post-TPIAT, narcotic usage and pain scores significantly decrease, with more genetic […]
Subcutaneous Fat Thickness Predicts Postoperative Seroma Risk
Subcutaneous fat thickness (TSF) is linked to higher postoperative seroma risk following laparoscopic hernioplasty. In a study of 229 male patients, factors like longer hernia duration, larger defects, and TSF ≥26.0 mm were associated with increased seroma risk. TSF ≥26.0 mm had an odds ratio of 7.033 for seroma development. TSF could serve as a […]
Laparo-endoscopic surgery reduces chronic inguinal pain post-hernioplasty
Laparo-endoscopic hernia surgery shows a lower likelihood of chronic inguinal pain compared to lichtenstein repair, with similar recurrence rates. This systematic review and meta-analysis of eight randomized controlled trials involving 1,469 patients provides robust evidence supporting the effectiveness of laparo-endoscopic mesh repair (TAPP and TEP) in reducing chronic pain following inguinal hernia repair procedures. Journal […]
Improved Risk Assessment Model for VTE Prophylaxis
The simplified three-factor risk assessment model for venous thromboembolism (VTE) in inguinal hernia patients resulted in higher prophylaxis rates, reduced assessment time, and lower d-dimer levels compared to the Caprini score. Patients identified as high-risk saw significant improvements in prophylaxis. The model did not increase VTE or bleeding risks, demonstrating potential for quick and effective […]
Thyroglobulin Wash-Out for Lymph Node Metastasis in Thyroid Carcinoma
Thyroglobulin wash-out after fine-needle aspiration cytodiagnosis effectively evaluates lymph node metastasis in papillary thyroid carcinoma. A cutoff value of 3.2 ng/ml for FNA-TG offers higher accuracy and lower false negatives than single diagnoses. Combining FNAC with FNA-TG increases sensitivity, though specificity decreases slightly. Ultrasonography provides dynamic LN assessment, enhancing diagnostic efficacy without added patient discomfort. […]
Extended Pharmacologic Prophylaxis Improves Survival in Colon Cancer Patients
Extended pharmacologic prophylaxis after colon cancer surgery is associated with improved overall and cancer-specific survival. Results suggest a potential anti-neoplastic effect from heparin derivatives in preventing post-surgical venous thromboembolism. A large database study of 20,102 patients showed significantly higher survival rates in patients who received extended prophylaxis. Multivariable analysis demonstrated a reduced risk of death […]
Metabolic Surgery Shows Superior Renoprotective Effects in CKD Patients
Metabolic surgery significantly reduces kidney impairment progression and lowers the risk of kidney failure or death by 60% and 44%, respectively, when compared to GLP-1 receptor agonists in patients with type 2 diabetes, obesity, and established chronic kidney disease. This highlights the potential of metabolic surgery as a therapeutic option for individuals with CKD and […]