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Best Papers in General Surgery
The five that matter, every day.
Liver transplant (LT) was associated with improved long-term survival compared to liver resection (LR) in patients with multifocal hepatocellular carcinoma (MHCC). Factors such as race, insurance status, and treatment facility influenced the likelihood of receiving LT. This study highlights the clinical and sociodemographic disparities between…
Analysis of 500 robotic hepatectomies revealed significant number of cases needed to achieve mastery in minor, major, and technically challenging resections. Surgeons can utilize this data to enhance patient safety and outcomes, providing valuable insights for those gaining experience in robotic hepatectomies. The findings highlight…
Personalized circulating tumor DNA monitoring using a tumor-informed assay significantly improves recurrence surveillance and management in patients with colorectal liver metastases. Detectable ctDNA at specific time points post-surgery is associated with higher recurrence risk, serving as an independent prognostic marker. Longitudinal ctDNA analysis accurately predicts…
Patients undergoing laparoscopic gallbladder-preserving cholecystolithotomy were divided into oxycodone and sufentanil groups. Oxycodone group showed lower pain scores postoperatively, indicating better analgesic effects and reduced inflammatory responses compared to sufentanil group. This prospective randomized controlled trial highlights the superior postoperative analgesia induced by oxycodone in…
Resection margin width significantly influences overall survival post liver resection for colorectal liver metastasis. A cohort study of 754 patients revealed poorer survival with margins of 0-0.9mm compared to ≥1mm, even in the era of modern chemotherapy. Narrow margins (
Adding complete mesogastric excision to D2 lymphadenectomy for gastric cancer improves 3-year disease-free survival without significant difference in overall survival rates. Recurrence rates were lower in the complete mesogastric excision group. This finding suggests potential benefits of the combined approach for better outcomes in advanced…
Utilizing periarterial and sub-adventitial divestment alongside the triangle operation and RAMPS, researchers achieved R0 resection in locally advanced pancreatic body cancer without compromising oncologic outcomes. The technique, demonstrated in a multimedia article, provides an alternative to morbid arterial resection, ensuring optimal tumor clearance and preserving…
Bromelain enhances cytotoxicity and mucolytic activity in appendiceal cancer tumors, reducing mucin production and increasing drug effectiveness in heated intraperitoneal chemotherapy (HIPEC) treatments. Combined with N-acetylcysteine, bromelain significantly reduces mucin levels and boosts cell death pathways like apoptosis and autophagy. These findings suggest a promising…
Paragastric neural blockade (PGNB) significantly reduces postoperative pain and nausea/vomiting after sleeve gastrectomy, as evidenced by lower visual analog scale (VAS) and postoperative nausea and vomiting (PONV) scores. Additionally, PGNB facilitates earlier mobilization and higher patient satisfaction compared to the control group, indicating its efficacy…
Study compares long-term outcomes of liver transplant (LT) and resection (LR) in patients with multifocal hepatocellular carcinoma (MHCC). LT associated with improved survival over LR, with LT patients more likely to be non-Hispanic white, privately insured, and treated at academic centers. Findings suggest LT may…
