This systematic review and meta-analysis delved into the often-debated realm of diagnosing and treating appendicitis in both adults and children. A comprehensive examination of 261 studies revealed nuances in care. For adults, CT scans showed high sensitivity and specificity. Uncomplicated appendicitis had varied outcomes with non-operative management, affecting readmission rates, the need for surgery, and […]
Category: General Surgery
Minimally Invasive Surgery Benefits Pancreatoduodenectomy Patients Post-Neoadjuvant Treatment
This study delves into the impact of surgical approach on the 30-day outcomes of pancreatic cancer patients after neoadjuvant treatment (NAT). Researchers compared minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD) within NAT groups. Among the 5,588 patients analyzed, MIPD after neoadjuvant chemotherapy alone resulted in lower complication rates, shorter hospital stays, and fewer complications […]
Thyroid Hormone Receptor Alpha: A Potential Game-Changer in Liver Fibrosis
This study explores the role of thyroid hormones (TH) and their receptor, TRα, in hepatic fibrogenesis, a key process in chronic liver disease. Researchers found that TRα plays a dominant role in hepatic stellate cells (HSC) and can modulate fibrogenic gene expression. TH, specifically T3, inhibited fibrogenic responses in HSC and reduced liver fibrogenesis in […]
Unveiling Factors Behind Unresolved Stomas in Rectal Cancer Surgery
This study delves into the factors contributing to the non-closure of temporary stomas following anterior resection for rectal cancer. Researchers identified several risk factors, including age over 60, advanced tumor stage, high American Society of Anesthesiologists (ASA) score, neoadjuvant chemoradiotherapy, open surgery, postoperative chemotherapy, anastomotic leakage, and local recurrence. Shockingly, one out of every five […]
Hepatic Steatosis and Fibrosis Not Linked to Postoperative Outcomes in Perihilar Cholangiocarcinoma
For those facing surgery for perihilar cholangiocarcinoma (pcca), concerns about hepatic steatosis and fibrosis were investigated. Analyzing data from 401 patients, researchers found that neither hepatic steatosis nor fibrosis were associated with postoperative outcomes, including posthepatectomy liver failure (phlf) or 90-day mortality. Instead, factors like preoperative cholangitis and liver remnant size proved to be more […]
Frailty’s Alarming Impact on Pancreatic Cancer Survival
This systematic review and meta-analysis delved into the world of pancreatic cancer, focusing on frailty. Among 35,191 patients, they discovered that 45% of pancreatic cancer patients were frail. This frailty took a toll, significantly reducing their chances of survival. While the results displayed some variation, they underscored the vital role of assessing frailty in pancreatic […]
Nomogram Predicts Tumor Deposits in Colorectal Cancer Patients
Researchers created a predictive model to identify tumor deposits (TDs) in colorectal cancer (CRC) patients. Analyzing data from these patients, the study revealed that variables such as female sex, preoperative intestinal obstruction, left-sided CRC, and lymph node metastasis are independent risk factors for TD formation. Their nomogram, with strong predictive performance, can assist surgeons in […]
Guidelines for Bowel Preparation in Minimally Invasive Colorectal Surgery
A collaborative project by EAES, SAGES, and ESCP developed clinical practice recommendations for bowel preparation before minimally invasive colorectal surgery. After conducting a systematic review and network meta-analysis, a panel of experts suggested different approaches for various procedures. They recommend mechanical bowel preparation (MBP) with oral antibiotics for certain cases and offer conditional recommendations for […]
Identifying Prognostic Factors for High-Risk Stage II Colon Cancer
In this analysis of high-risk stage II colon cancer patients, significant prognostic factors for disease-free survival (DFS) and overall survival (OS) were determined. Gender, tumor invasion depth, extent of lymph node dissection, number of examined lymph nodes, and postoperative adjuvant chemotherapy (POAC) were found to be independent predictors of DFS. Similarly, age, gender, tumor invasion […]
Comparing Surgical Approaches for Incisional Hernia Repair After Pancreatic Surgery
After analyzing data from the Herniamed registry, which included patients who underwent incisional hernia repair following pancreatic surgery, researchers found that both open and minimally invasive techniques were effective and safe, with low recurrence rates. Of the patients with one-year follow-up, 95% had previously undergone open pancreatic surgeries. Notable differences included a higher rate of […]