Newsletter
Best Papers in General Surgery
The five that matter, every day.
Researchers validated a quantitative method for precise polyp size and location measurement in upper gastrointestinal endoscopy, critical for malignancy prediction and intervention planning. Using an electromagnetic tracking sensor, the method showed high accuracy in a simulated endoscopy setting, with an average polyp size of 12mm…
Gadoxetate disodium-enhanced MRI can predict post-hepatectomy liver failure. Low signal intensity of the remnant liver compared to the spleen post-contrast is associated with higher odds of liver failure. Functional liver remnant determined by this imaging can accurately predict post-hepatectomy liver failure, with a specific cut-off…
Quantifying methylated circulating tumor DNA effectively monitors HCC burden without the need for biopsy. Tumor methylation scores rapidly decline postoperatively in surgical HCC patients. Preoperative tms moderately correlates with tumor burden on pathology. Δtms is better associated with tumor progression than Δalpha-fetoprotein, and a composite…
Intravenous administration of an oncolytic virus (cf33) engineered to express a nonsignaling CD19 antigen (CD19t) effectively infected and expressed CD19t in pancreatic tumors, triggering cell killing and increased immunogenic response by CD19-CAR T cells. Combination therapy of virus+CAR T cells led to significant tumor regression…
Cholecystectomy for uncomplicated cholelithiasis in sickle cell disease (SCD) patients leads to lower postoperative vaso-occlusive crises compared to those with acute cholecystitis, chronic cholecystitis, or gallstone pancreatitis. Advanced clinical presentations are strong predictors of complications, with 73% of SCD patients showing advanced clinical presentation at…
By using continuous preventable mortality review to guide provider education, the Arkansas Trauma System saw a progressive reduction in preventable or potentially preventable deaths from 2015 to 2022. A total of 1,979 trauma deaths were analyzed, with a 43% decrease in preventable or potentially preventable…
Home call for acute care surgeons results in decreased sleep and increased burnout, with even non-active home calls contributing to sleep loss and burnout. Each additional call or return to the hospital during home call further exacerbates these negative effects. This study highlights the importance…
Researchers compared capsule-based pH testing and GERD symptom scoring in bariatric surgery patients. They found no significant difference in GERD symptom scores between patients with and without a diagnosis based on pH testing. Objective pH testing may aid in procedure selection and informed consent, potentially…
Analysis of 125 patients with molecular profiling for intrahepatic cholangiocarcinoma revealed actionable molecular alterations in 45%, leading to targeted therapies in 21 patients. Patients with such alterations had significantly improved overall survival, with mean survival of 34.1 vs 23.6 months in those with actionable alterations.…
Left-sided liver resection for perihilar cholangiocarcinoma is associated with lower 90-day mortality and superior overall survival compared to right-sided resection. In a study of 1701 patients, 90-day mortality rates were 9% for left-sided and 18% for right-sided resection, with median overall survival of 30 months…
