A study involving 459 gastric cancer patients showed that indocyanine green (ICG)-guided lymphadenectomy significantly enhanced survival outcomes after neoadjuvant chemotherapy. Patients in the ICG group had a higher number of lymph nodes harvested and demonstrated improved three-year overall survival (78.6% vs 66.6%) and recurrence-free survival (74.0% vs 57.0%) compared to non-ICG counterparts. Efficacy was particularly […]
Category: Upper Gastrointestinal Tract
Nomograms Enhance Prognostic Accuracy in Early Gastric Cancer with Lymph Node Metastasis
A study established two nomograms to predict risks and prognosis for T1-T2 stage gastric cancer patients with lymph node metastasis. Analyzing data from 5,350 patients, key risk factors included age, tumor size, and grade. The developed nomograms demonstrated excellent calibration and clinical applicability, significantly distinguishing overall survival between low-risk and high-risk groups. These tools aim […]
New prognostic score improves survival predictions in gastric cancer
A novel prognostic oxidative stress-immune-inflammation score (posii score) has been developed to enhance survival predictions for gastric cancer patients post-radical gastrectomy. Analysis of 3,612 patients revealed that those in the low posii group exhibited significantly higher 5-year overall and disease-free survival rates, along with reduced recurrence risks (p < 0.05). Two validated online calculators based […]
Neoadjuvant immunochemotherapy shows promising outcomes in esophageal cancer.
A multicenter retrospective study evaluated neoadjuvant immunochemotherapy involving PD-1 agents plus platinum-based chemotherapy for 213 patients with resectable esophageal cancer. The study reported a high pathological complete response (PCR) rate of 31.9%, with a complete tumor resection (R0) rate of 99.1%. Additionally, two-year disease-free survival (DFS) and overall survival (OS) rates were notable at 78.9% […]
EBV positivity improves survival rates in gastric cancer patients
In a multicenter study, significant differences in long-term survival were observed between patients with Epstein-Barr virus-associated gastric cancer (EBVAGC) and those with Epstein-Barr virus-negative gastric cancer (EBVNGC) after radical gastrectomy. The 3-year overall and disease-free survival rates were notably higher in the EBVAGC group. Additionally, positivity for Epstein-Barr virus-encoded small RNA served as an independent […]
Advances in managing gastric cancer with peritoneal metastasis
Recent insights into gastric cancer with peritoneal metastasis (gcpm) reveal dismal outcomes, underscoring the need for improved management strategies. A growing body of clinical trials investigates the efficacy of cytoreductive surgery (crs) combined with hyperthermic intraperitoneal chemotherapy (hipec), recognized in new national guidelines. Enhanced understanding of gcpm’s mechanisms and novel therapeutic targets could lead to […]
Updated guidelines enhance GERD diagnosis and management strategies
The American Society for Gastrointestinal Endoscopy’s updated guidelines provide an evidence-based framework for diagnosing and managing gastroesophageal reflux disease (GERD). The recommendations cover endoscopic evaluations, lifestyle modifications, and treatment options, including proton pump inhibitors and innovative endoscopic therapies. Key changes include guidelines for patients with prior surgical procedures and emphasis on detailed endoscopic assessments. Additionally, […]
Red Cell Distribution Width-To-Albumin Ratio Predicts Peptic Ulcer Outcomes
In a study involving 187 patients with peptic ulcer perforation, the red cell distribution width-to-albumin ratio (RAR) was found to be a strong prognostic marker for predicting major postoperative complications and 30-day mortality. The analysis revealed RAR, alongside age and surgical delay, as independent predictors of complications, with RAR demonstrating high sensitivity and specificity (AUC […]
Cytoreductive surgery with HIPEC and IORT enhances gastric cancer survival
Findings indicate that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) and intraoperative radiation therapy (IORT) significantly improves overall survival (63 months) and disease-free survival (87 months) for gastric cancer patients. Over one-third of participants experienced no postoperative complications, while those who did faced a median of just one complication, primarily grade II. The absence […]
Machine learning model effectively predicts postoperative recurrence in duodenal adenocarcinoma
A machine learning-based model has been developed to predict postoperative recurrence in patients with duodenal adenocarcinoma, utilizing data from 1,830 patients who underwent radical surgery. Among 100 predictive models tested, the penalized regression + accelerated oblique random survival forest model (pam) delivered the highest performance with a concordance index (c-index) of 0.882 in the training […]