Advances in endoscopic techniques for treating upper gastrointestinal submucosal tumors (SMTs) are promising, with innovations enhancing diagnosis and therapeutic options. The study evaluates diverse endoscopic strategies and their efficacy, indicating they are minimally invasive and expedite recovery compared to traditional surgery. Despite these advancements, concerns regarding patient safety and comprehensive efficacy remain. By summarizing recent […]
Category: Upper Gastrointestinal Tract
Endoscopic gastrojejunostomy shows benefits over surgical options
Findings indicate that endoscopic gastrojejunostomy (EGJ) is associated with fewer peri-procedural complications compared to surgical gastrojejunostomy (SGJ) for patients with malignant gastric outlet obstruction. Data from over 20,000 hospitalizations from 2016 to 2020 revealed that EGJ resulted in lower rates of respiratory failure, blood transfusions, and peritonitis, alongside reduced hospitalization costs and shorter stays. The […]
New survival model offers real-time predictions for gastric cancer
A dynamic survival prediction model for gastric neuroendocrine carcinoma (GNEC) was developed using machine learning and conditional survival (CS) analysis. Data from 654 patients were split into training and validation sets. The CS model demonstrated improved 5-year survival probabilities, rising from 48% at diagnosis to 94% after four years. Key prognostic factors—age, tumor grade, stage, […]
Nomogram predicts complications in robotic radical gastrectomy patients
A predictive nomogram was developed to assess the risk of postoperative complications in gastric cancer patients undergoing robotic-assisted radical gastrectomy. The study analyzed data from 636 patients across two cohorts and identified five independent risk factors: tumor diameter, TNM stage III, ASA classes I and III, and visceral fat area. The nomogram demonstrated good discrimination, […]
Eight interventions proved effective in preventing post-operative stenosis
A systematic review and network meta-analysis identified eight effective interventions for preventing postoperative esophageal stenosis following endoscopic resection of superficial cancer. Notable approaches included the combination of polyglycolic acid with a steroid and botulinum toxin. These interventions also led to significant reductions in the number of endoscopic balloon dilatation sessions needed. Importantly, none of the […]
Tumor-Stroma Ratio Accurately Predicts Peritoneal Metastasis in Gastric Cancer
Analysis reveals a strong correlation between tumor-stroma ratio (tsr) and peritoneal metastasis (pm) in gastric cancer patients. The study included 640 patients across several cohorts, establishing a diagnostic model integrating tsr with CA125, CA724, and Borrmann type. The model demonstrated robust predictive capabilities, achieving an area under the curve (AUC) of 0.85 in the training […]
Preoperative ctDNA status predicts recurrence risk in esophageal cancer
Preoperative circulating tumor DNA (ctDNA) analysis shows significant prognostic value in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemotherapy followed by surgery. Among 25 patients, those with ctDNA detected post-treatment faced a recurrence-free survival rate of only 8% at 36 months, compared to 92% for ctDNA-negative patients (p < 0.001). These findings highlight […]
Significant research waste identified in gastroesophageal trials
Over the past 20 years, an analysis of 182 randomized controlled trials (RCTs) on gastroesophageal reflux disease and hiatal hernia highlighted that over 86.7% exhibited significant research waste. The majority of trials were drug-related, primarily conducted in North America and Asia, with deficiencies found in various aspects such as reporting adequacy and design flaws. This […]
Nomogram effectively predicts postoperative pneumonia post-esophageal ESD
A novel nomogram has been developed to predict postoperative pneumonia risk after esophageal endoscopic submucosal dissection (ESD). In a cohort of 492 patients, the incidence of pneumonia was 18.6%. Key predictive factors included female sex, older age, low serum albumin levels, prolonged operative duration, muscular layer damage, and comorbid pulmonary diseases. The nomogram exhibited robust […]
Tumor downstaging improves survival in esophageal adenocarcinoma patients
Analysis of 6,400 esophageal adenocarcinoma patients revealed that 51% experienced tumor downstaging after neoadjuvant chemoradiation, with complete downstaging noted in 5%. Downstaging correlated with a 31% and 17% reduced risk of death compared to disease progression and stable staging, respectively. Additionally, robotic-assisted minimally invasive esophagectomy reduced mortality risk by 17% compared to open surgery, while […]