A prognostic nomogram was developed to estimate long-term survival for esophageal squamous cell carcinoma patients post-surgery. Using data from 224 patients, key variables influencing outcomes included tumor location, anastomotic fistula incidence, and vascular invasion, with lymph node clearance linked to improved survival. The nomogram displayed strong predictive capabilities through various assessment methods, confirming its practical […]
Category: Upper Gastrointestinal Tract
Integrating Lipid and Inflammation Scores Enhances Gastric Cancer Prognosis
Incorporating the Circulating Lipid and Inflammation Risk Score (CLIRS) significantly predicts long-term survival in gastric cancer patients. Analysis of 2,534 patients revealed that CLIRS is an independent prognostic factor for overall (HR 1.529) and disease-free survival (HR 1.511). Nomograms based on CLIRS outperformed traditional pTNM staging in forecasting postoperative outcomes, highlighting that high-risk patients face […]
Proficiency in robot-assisted esophagectomy improves after 27 cases
A study on robot-assisted minimally invasive McKeown esophagectomy revealed a significant reduction in operation time associated with increased surgical proficiency. Analyzing 83 cases, researchers found that transitioning from the initial learning phase (cases 1-27) to the proficiency phase (cases 28-83) resulted in a drop in mean operation time from 329.6 minutes to 221.3 minutes (p
Surgical resection improves survival for gastric cancer liver metastases
A population-based analysis of 3,694 gastric cancer patients with liver metastases revealed that those undergoing cancer-directed surgery experienced significantly longer median overall survival, 12 months versus 6 months for non-resection patients. After adjusting for selection bias, Cox regression indicated a substantial survival benefit, with a hazard ratio of 0.562. These findings highlight the importance of […]
Surgical options enhance treatment for achalasia patients
A review of recent literature highlights effective surgical interventions for achalasia, including laparoscopic/robotic heller myotomy (LHM/RHM) and fundoplication methods. Both approaches exhibit low morbidity and mortality rates, with RHM offering advantages like improved procedural visibility and reduced risk of mucosal laceration. The findings suggest surgery is particularly beneficial for patients under 40 or those with […]
Expert Consensus Established on Postoperative Symptoms After Oesophago-gastric Cancer Surgery
A multidisciplinary expert panel achieved consensus on 26 postoperative symptoms and management of 10 related conditions following oesophago-gastric cancer surgery. Defined diagnostic criteria and first-line treatments were agreed upon to improve patient care and quality of life. Notably, 85.7% of symptoms were identified as potential indicators of cancer recurrence. However, agreement on further treatment levels […]
Predictive model effectively identifies surgical margin risks in esophageal cancer.
A pathology-based predictive model for positive surgical margins (PSM) in esophageal squamous cell carcinoma (ESCC) has been established and validated. Analysis of 1,776 patients revealed that multifocal lesions, vascular invasion, and pathomics-based features significantly predict PSM. The decision tree model displayed excellent discrimination with an area under the ROC curve of 0.899, while the nomogram […]
Modified nutritional index predicts survival in elderly gastric cancer patients
A novel modified nutritional index model (mcns) demonstrated high predictive value for long-term survival among elderly patients with advanced gastric cancer. Analyzing data from 555 patients, the study identified tumor size, pn, and the modified nutritional score (mconut) as independent prognostic factors, improving patient risk stratification. Notably, patients in the low-risk group benefiting from adjuvant […]
New treatment guidelines enhance management of esophageal and gastric cancer.
Comprehensive updates on the treatment of esophageal and gastric cancer emphasize the crucial role of perioperative systemic therapy. Neoadjuvant chemoradiotherapy followed by postoperative immunotherapy is standard for locally advanced squamous cell carcinoma, while perioperative FLOT chemotherapy shows superior outcomes for adenocarcinoma. Promising results are also noted for MSI-high tumor patients receiving neoadjuvant immunotherapy. The focus […]
Modified apprenticeship models could enhance esophageal ESD training.
Endoscopic resection techniques, like ESD, offer safer alternatives to esophagectomy for esophageal cancer. While ESD provides complete histopathological assessment, a consensus on training models remains elusive. The effectiveness of Japan’s apprenticeship model contrasts with the West’s comprehensive methods that combine various training approaches. Researchers suggest adapting a modified apprenticeship model to optimize ESD training outcomes. […]