Laparoscopic HIPEC for gastric cancer with peritoneal metastasis is safe and associated with minimal perioperative complications. Approximately one third of patients undergoing initial laparoscopic HIPEC proceeded to cytoreduction and gastrectomy. Preliminary survival data from this study indicate a median overall survival of 11 months from the initial procedure and 19.3 months from the diagnosis, suggesting […]
Category: Upper Gastrointestinal Tract
Why are Intraoperative Adverse Events Important in Robotic Radical Gastrectomy for Gastric Cancer?
Assessment of intraoperative adverse events (IAEs) during robotic radical gastrectomy for gastric cancer revealed that IAEs significantly correlated with postoperative complications and poor long-term prognosis. The presence of IAEs was associated with worse overall and disease-free survival rates compared to patients without IAEs. Utilizing the classintra grading system for quality control and prognostic evaluation is […]
Diagnostic Laparoscopy with Peritoneal Lavage in Gastric Adenocarcinoma: High Diagnostic Yield and Impact on Management
Diagnostic laparoscopy with peritoneal lavage in gastric adenocarcinoma has a high diagnostic yield, with 24.5% of patients having positive findings leading to exclusion from neoadjuvant treatment or surgical resection. Peritoneal metastases were identified in 10.3% of patients, with 12.5% having positive peritoneal cytology without macroscopic disease. Diffuse type carcinoma had the highest risk of peritoneal […]
High waist circumference positively affects clinical outcomes in esophageal cancer patients receiving immune checkpoint inhibitors.
In patients with unresectable or recurrent esophageal cancer receiving immune checkpoint inhibitors, high waist circumference was associated with favorable progression-free survival and disease control rates. This suggests that body composition, specifically waist circumference, may influence clinical outcomes in esophageal cancer patients undergoing ICI treatment. Journal Article by Kosumi K, Baba Y (…) Baba H et […]
Active Surveillance for Complete Responders in Oesophageal SCC: Better Progression-Free Survival
Patients with oesophageal squamous cell carcinoma who underwent active surveillance after chemoradiotherapy showed comparable overall survival but better progression-free survival than those who had planned surgery. The two groups had similar overall recurrence rates, with locoregional recurrence more common in the active surveillance group and systemic recurrence more common in the surgery group. Active surveillance […]
Does Laparoscopic Gastric Ischemic Preconditioning Reduce Anastomotic Stricture Rate After Esophagectomy?
According to the study, laparoscopic gastric ischemic preconditioning (LGIP) may decrease the rate and severity of anastomotic strictures following esophagectomy. Of the patients who underwent LGIP, only 7.1% developed anastomotic strictures compared to 19.9% in the control group. While controlling for confounders, the difference was no longer significant. There was also a trend towards less […]
Intraoperative Leak Testing Reduces Anastomotic Leakage in Gastric Cancer Surgery
Intraoperative leak testing (IOLT) significantly reduced postoperative anastomotic leakage (PAL) incidence compared to no intraoperative leak testing (NIOLT) in gastric cancer surgery. IOLT was associated with lower rates of anastomotic-related complications and reoperations. These findings suggest that IOLT is a promising tool to improve postoperative outcomes in gastric cancer surgery, emphasizing the need for further […]
Tumor Volume Fails to Predict Pathologic Response in Esophageal Adenocarcinoma
Researchers analyzed 287 esophageal cancer patients to assess if initial tumor volume on CT scans correlated with histomorphological regression after neoadjuvant therapy. Despite measuring tumor volumes and assessing regression grades, no significant relationship was found. The study concludes that tumor volume does not predict histopathological response in esophageal adenocarcinoma patients undergoing neoadjuvant treatment, highlighting the […]
Sizing Protocol Does Not Impact Outcomes of Magnetic Sphincter Augmentation
Sizing protocol (pop+2 vs pop+3) in magnetic sphincter augmentation did not impact outcomes like dysphagia, ph normalization, or need for dilation or removal. Upsizing did benefit patients with poor peristalsis or hypercontractile esophagus. Device size increase correlated with demographic and preoperative characteristics, suggesting it is a surrogate for esophageal circumference. Journal Article by Sarici IS, […]
Key Advances in Multimodality Management of Gastroesophageal Cancers
Recent studies have confirmed the long-term safety and efficacy of laparoscopic distal gastrectomy compared to open gastrectomy for locally advanced gastric cancer. Ongoing trials are evaluating perioperative immunotherapy for resectable gastric cancers. Key trials like dante, gercor neonipiga, keynote-859, and spotlight are exploring targeted therapies for unresectable or metastatic gastroesophageal cancers, incorporating immune checkpoint inhibitors […]
