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Upper Gastrointestinal Tract

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Dysphagia9 Feb 2024

Big Data Analysis Reveals Hiatus Hernia’s Link to Esophageal Disorders

Researchers conducted a comprehensive analysis using big data to investigate the frequency of hiatus hernia (hh) and its association with esophageal disorders. They reviewed endoscopic reports of over 75,000 patients and found that hh was present in 16.8% of cases, with the majority being small…

Ann Surg Oncol7 Feb 2024

Optimal Time-to-Surgery Recommendations Based on Tumor Shrinkage for Resectable Esophageal Cancer

A retrospective study analyzed the outcomes of patients with resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) who underwent neoadjuvant chemoradiotherapy. Researchers found that tumor shrinkage rate is an independent prognostic factor for progression-free survival (PFS). For patients who responded to treatment, extending the time-to-surgery…

Ann Surg Oncol5 Feb 2024

SMG: A Novel Muscle Parameter Predicts Prognosis in Resectable Gastric Cancer

The study included 717 patients and found that the new muscle parameter, SMG, obtained by multiplying the skeletal muscle index (SMI) and skeletal muscle radiation attenuation (SMRA), can predict the prognosis of patients with gastric cancer. The findings showed that SMG can effectively predict both…

Upper Gastrointestinal Tract2 Feb 2024

Management Strategies for Refractory Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is a common condition with increasing prevalence worldwide and a high economic burden. Despite proton pump inhibitor (PPI) therapy, a significant number of patients remain symptomatic. This review highlights the importance of differentiating between unproven GERD and refractory GERD, and provides…

Ann Surg Oncol31 Jan 2024

Adjuvant Nivolumab Shows Promising Results in Patients with Tumor-Positive Resection Margin Following Chemoradiotherapy and Esophagectomy

Approximately 4-9% of patients had a tumor-positive resection margin after neoadjuvant chemoradiotherapy (ncrt) and esophagectomy. Only a small proportion of patients received adjuvant therapy, despite the association of positive margins with decreased survival. However, a real-world study revealed that 61% of patients were treated with…