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Discontinuous growth (DG) in esophageal adenocarcinoma (EAC) is associated with adverse clinicopathologic features and worse patient outcomes. DG was found to be an independent adverse predictor of survival outcomes in EAC, even after adjusting for other factors such as tumor size and stage. This multi-institutional…
Induction chemotherapy followed by response evaluation and esophagectomy in patients with advanced esophageal cancer showed promising results in terms of survival. A total of 238 patients were treated with taxane/platinum-based chemotherapy, with 64.7% undergoing surgical exploration. Resection was performed in 53.4% of patients, resulting in…
Researchers conducted a study to develop and validate a nomogram for predicting overall survival (OS) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Using data from the SEER registry, they identified key prognostic factors and compared the nomogram's performance to the AJCC staging system. The results…
A revised ypStage grouping system was proposed for esophageal squamous cell carcinoma patients who underwent neoadjuvant chemoradiotherapy followed by surgery. The new system adequately addressed the limitations of the existing American Joint Committee on Cancer (AJCC) system, showing improved prognostic relevance and higher discrimination ability.…
The book-binding technique (BBT) is a safe and feasible method for intracorporeal gastroduodenostomy in totally laparoscopic distal gastrectomy (TLDG) for patients with gastric malignancy. This retrospective study evaluated 188 patients who underwent TLDG with BBT reconstruction, showing low rates of anastomotic stenosis and leakage. The…
Based on a cost-effectiveness analysis, researchers found that PCT is the most cost-effective management modality for LAGC compared to upfront surgery (US). PCT yielded 3.11 quality-adjusted life-years (QALYs) at a cost of $40,792.16, while US yielded 3.15 QALYs at a cost of $55,575.57. The incremental…
The multicentre cohort study aimed to compare the long-term oncological outcomes between robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) for patients with gastric cancer. The study included a total of 2,055 patients who underwent RG and 4,309 patients who underwent LG. After matching the patients…
High socioeconomic deprivation, as measured by the area deprivation index (ADI), significantly reduces the likelihood of receiving guideline-concordant treatment (GCT) for foregut cancers. In a retrospective study of 498 patients, 66% received GCT, with lower rates observed in pancreatic, gastric, and hepatobiliary cancers. Factors independently…
Asian Americans face higher 30-day surgical complications following esophagectomy compared to Caucasians, according to a retrospective analysis of the ACS-NSQIP database. The study found that Asian Americans had a greater likelihood of pulmonary complications, particularly pneumonia, renal dysfunction, including progressive renal insufficiency, and bleeding events.…
The study aimed to evaluate the impact of gastrectomy with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on the outcomes of gastric cancer (GC) patients with limited peritoneal disease progression following neoadjuvant chemotherapy (NAC). Results showed that there was no survival benefit among advanced…
