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Rethinking Surgical Trials in Esophagogastric Cancer

Multicenter trials in esophagogastric cancer have not improved overall survival, raising urgent questions about trial design.

  • 27 trials were analyzed; only 10 aimed for survival superiority, none achieved significant benefits.
  • Common issues included limited surgeon credentialing and poor adherence monitoring.
  • Trials often lacked adequate power and internal piloting, with a 10% nonadherence potentially halving statistical power.

Surgeons should advocate for more rigorous quality assurance in trial design to enhance outcome validity.

Review by Das B, Mitra AT, Bossuyt P and Hanna GB in Ann Surg Oncol

© 2025. The Author(s).

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Low Ligation of IMA Enhances Survival in Rectosigmoid Surgery

Low ligation of the inferior mesenteric artery improves outcomes for rectal and sigmoid cancer patients.

  • Low ligation significantly boosts 5-year overall survival (HR 0.69, p = 0.026).
  • It reduces anastomotic leak rates (OR 0.71, p = 0.050) without affecting disease-free survival or lymph node yield.
  • No increase in overall complications, operative time, or blood loss was observed.

This supports low ligation as the preferred technique in rectosigmoid cancer surgery for better patient outcomes.

Review by Sassun R, Sileo A (…) Larson DW et 6 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Endoscopic Ultrasound Outperforms PTBD for Biliary Obstruction

Endoscopic ultrasound (EUS) is a cost-effective strategy for managing malignant distal biliary obstruction (MDBO) after failed ERCP, leading to better outcomes.

  • EUS-guided biliary drainage (EUS-GB) cost $14,520, yielding 0.38 QALYs and an incremental net monetary benefit (NMB) of $37,768.
  • EUS-guided choledochoduodenostomy (EUS-CBD) cost $17,694, providing 0.55 QALYs and an incremental NMB of $52,171.

EUS techniques show comparable outcomes to percutaneous options, offering advantages with potentially lower reintervention rates.

  • PTBD costs $14,988 but provides fewer QALYs and is deemed less effective.

Journal Article by Siranart N, Pajareya P and Steinway SN in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Innovative ultrasound technique enhances liver surgery outcomes

A novel ultrasound-guided technique to compress the middle hepatic vein allows for better detection of left-sided communicating veins, improving surgical options.

  • Left-sided communicating veins were detected in 71% of patients using this method.
  • Surgical strategies were modified in 57% of patients, enabling more parenchyma-sparing resections.

This technique could expand the criteria for liver resections and improve patient outcomes in cases involving the caval confluence.

  • Major complications occurred in only 5%, with no perioperative mortality.

Journal Article by Procopio F, Galvanin J (…) Torzilli G et 4 al. in Updates Surg

© 2025. Italian Society of Surgery (SIC).

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Transcutaneous Ultrasound Offers Hope for Vocal Cord Paralysis Diagnosis

Transcutaneous laryngeal ultrasound shows promise in detecting vocal cord paralysis after esophagectomy, crucial for surgical outcomes.

  • Pooled sensitivity of 79% and specificity of 95% highlight its potential as a diagnostic tool.
  • Vocal cord visualization achieved rates of 92.3%, with a 29% incidence of vocal cord paralysis post-surgery.

Consider this tool for assessing high-risk patients, but be aware of a notable 20% false-negative rate.

  • Further multicenter studies are essential to enhance detection protocols, especially in elderly patients.

Review by Luo X, Xiong J (…) Zhu Y et 7 al. in Esophagus

© 2025. The Author(s) under exclusive licence to The Japan Esophageal Society.

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Guidelines Improve Barrett’s Esophagus Surveillance

Surgeons should know that new guidelines clarify endoscopic surveillance for Barrett’s esophagus (BE) to reduce the risk of esophageal adenocarcinoma.

  • A conditional recommendation supports surveillance for patients with nondysplastic BE.
  • Strong recommendation for high-definition white light endoscopy combined with chromoendoscopy over white light alone.
  • No specific endorsement for enhanced sampling techniques or biomarkers to predict progression.

These recommendations emphasize high-quality endoscopy and structured biopsy protocols, enhancing patient outcomes.

Practice Guideline by Wani S, Zhou MJ (…) Davitkov P et 9 al. in Gastroenterology

Copyright © 2025 AGA Institute. Published by Elsevier Inc. All rights reserved.

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Alcohol Withdrawal Syndrome Complicates Surgery Outcomes

Patients undergoing major surgery with alcohol withdrawal syndrome (AWS) face worse outcomes and higher costs.

  • AWS affected 0.5% of 3 million surgical patients, increasing complications by 37% and respiratory failure risk by 144%.
  • Length of stay was significantly longer at 11 days versus 6 days, with hospitalization costs surging by $10,030 per patient.

AWS screening is critical for improving surgical outcomes and managing costs.

  • Delirium tremens further raised mortality risks and added over 5 days to the hospital stay.

Journal Article by Sarfraz A, Mevawalla A (…) Pawlik TM et 4 al. in J Am Coll Surg

Copyright © 2025 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Surgery Alone Improves Outcomes in Resectable Pancreatic Cancer

Surgical resection without multimodal treatment for early-stage pancreatic cancer can lead to better survival outcomes.

  • Upfront surgery showed a median overall survival of 14.09 months compared to 6.34 months for those who refused surgery.
  • One-year survival rates were 56% with surgery versus 26% without.
  • R0 resection patients had a median survival of 17.87 months, significantly outpacing the 7.56 months in non-R0 cases.

Surgeons should consider early resection even in patients unable to tolerate multimodal therapies, particularly aiming for R0 margins for optimal outcomes.

Journal Article by Anteby R, Fagenholz PJ (…) Qadan M et 3 al. in J Am Coll Surg

Copyright © 2025 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Novel Risk Score Predicts Pancreatic Fistula After Surgery

A new preoperative scoring system enhances risk stratification for clinically relevant postoperative pancreatic fistula (cr-popf) after pancreatoduodenectomy, potentially improving surgical outcomes.

  • The 6-point score boasts an area under the ROC curve of 0.89, with 81.8% sensitivity and 91.7% specificity.
  • cr-popf incidence is 4.6% in low-risk patients versus 82.5% in very-high-risk patients.

Implementing this tool allows for tailored surgical plans and preventive measures, potentially reducing complications.

  • Key factors include pancreatic attenuation ≤30 Hounsfield units, duct-to-parenchyma ratio ≤0.2, main pancreatic duct diameter <3 mm, and BMI ≥25 kg/m².

Journal Article by Symonov O, Usenko O, Pavliuk R and Prysyazhnyuk Y in J Gastrointest Surg

Copyright © 2025 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.

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Understanding Recurrence Patterns Post-Colorectal Liver Metastasis Surgery

Tailored postoperative surveillance can significantly improve outcomes for colorectal liver metastases patients.

  • Among 962 patients, isolated liver recurrence was most common (49.7%) within 5 months.
  • Bilateral disease showed higher risk with R1 resection (20.9% vs. 14.4%) and greater modified tumor burden scores (8.1 vs. 3.4).

Surgeons should prioritize early, personalized follow-up, especially for high burden and bilateral disease.

  • Intra-/extrahepatic multi-site recurrences peaked at 8 months, emphasizing the need for ongoing assessment.

Journal Article by Chatzipanagiotou OP, Kawashima J (…) Pawlik TM et 13 al. in Eur J Surg Oncol

Copyright © 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

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