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ACS NSQIP Risk Calculator Shows Strong Performance in High-Risk Patients

The ACS NSQIP Risk Calculator demonstrated excellent calibration and good discrimination in predicting mortality and morbidity across 21 patient subsets, regardless of risk factors. Observed mortality rates varied significantly, from 0.04% to 60.01%, while morbidity ranged from 3.33% to 59.17%. Both the current machine learning algorithm (xgb) and a potential future algorithm (catb) showed consistent accuracy (ape < 10% and auc > 0.7), proving the tool’s value in surgical decision-making for high-risk populations.

Journal Article by Cohen ME, Liu Y, Hall BL and Ko CY in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Robotic pancreaticoduodenectomy lowers complications and hospital stays

A recent study revealed that robotic pancreaticoduodenectomy (RPD) significantly reduces the rate of clinically relevant pancreatic fistulas (10%) compared to open pancreaticoduodenectomy (OPD) (33.3%). Patients undergoing RPD also experienced shorter hospital stays (15 days) versus 22.5 days for OPD. Despite longer operative times for RPD, overall hospital costs were similar between the two approaches, as higher surgical costs were counterbalanced by fewer postoperative complications and reduced hospitalization.

Journal Article by Wakabayashi T, Gaudenzi F (…) Wakabayashi G et 7 al. in Surg Endosc

© 2025. The Author(s).

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Nationwide variation in cholecystitis treatment identified.

A nationwide observational study in the Netherlands aims to investigate treatment variations for cholecystitis across 67 hospitals. Despite existing guidelines, adherence to recommended treatments remains low. The study will assess the percentage of patients receiving early cholecystectomy and identify factors influencing guideline adherence. Researchers will also evaluate the best treatment methods for specific cases and the impact of adherence on hospital stays and morbidity, ultimately seeking to optimize treatment approaches and improve patient outcomes.

Journal Article by van Maasakkers MHG, Weijs TJ (…) Boerma D et 4 al. in BMJ Open

© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.

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Early mobilization enhances recovery for abdominal cancer surgery patients

Mobilizing patients with abdominal neoplasms within 24 hours post-surgery significantly improved their mobility compared to those receiving standard physiotherapy. Patients in the intervention group displayed higher mobility scores on the ICU Mobility Scale, both initially and at discharge from the ICU, indicating a positive outcome for early mobilization. While both groups experienced a decline in performance on the timed up and go test, the decline was notably significant only in the control group.

Journal Article by Silva FSS, Lima GBB (…) Amorim CEN et 3 al. in J Surg Oncol

© 2025 The Author(s). Journal of Surgical Oncology published by Wiley Periodicals LLC.

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Intersphincteric complex excision improves survival in rectal cancer.

The intersphincteric complex serves as a metastasis niche in ultralow rectal cancer, with 30.96% of patients showing tumor presence in this area. Complete excision of the complex correlates with significantly improved disease-free survival and local recurrence-free survival rates (HR, 0.382; p=0.008 and HR, 0.251; p=0.012, respectively). These findings emphasize the anatomical and prognostic importance of the intersphincteric complex in surgical procedures for ultra-low rectal cancer, offering insights for enhanced patient outcomes.

Journal Article by Yan S, Zhou M (…) Xiang J et 5 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Prophylactic clipping is cost-saving after endoscopic mucosal resection.

A cost-effectiveness analysis involving 4,557 patients found that prophylactic clipping (PC) during endoscopic mucosal resection (EMR) of large non-pedunculated colon polyps is beneficial. For a typical 65-year-old undergoing EMR, PC yielded an incremental cost-effectiveness ratio (ICER) of -$154,706. It proved cost-effective for very large polyps (≥40 mm) and cost-saving for patients on antithrombotic therapy when using up to two clips. Optimizing clip costs and usage enhances PC’s economic viability.

Journal Article by Sonaiya S, Patel R (…) Mohan B et 7 al. in Gastrointest Endosc

Copyright © 2025 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

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Intensive Neoadjuvant Chemotherapy Enhances Survival in Pancreatic Cancer

An analysis of 184 patients with anatomically resectable pancreatic cancer and elevated CA19-9 levels demonstrated that those receiving intensive neoadjuvant chemotherapy (NAC) showed significantly improved overall survival compared to those undergoing upfront surgery, with median survival times of 52.7 months versus 22.7 months (p < 0.001). Additionally, higher lymph node-negative resection rates and better post-resection CA19-9 normalization were observed in the NAC group, indicating its potential benefits for patients with CA19-9 > 500 U/mL.

Journal Article by Omiya K, Oba A (…) Takahashi Y et 10 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Visual models enhance prediction of rebleeding risk post-EVL

A retrospective study involving 629 patients evaluated rebleeding rates after endoscopic variceal ligation (EVL). Results revealed rebleeding in 34.8% and 80.1% of patients within 6 weeks and 6 months, respectively. Identified factors included esophageal variceal severity and platelet count, both independent risk predictors. Developed visual nomogram models showed high predictive accuracy, with AUCs of 0.942 for 6-week and 0.852 for 6-month risks. This model seeks to optimize patient management strategies and clinical decision-making.

Journal Article by Li B, Li Y (…) Wu Y et 6 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Multimodal system enhances diagnostic accuracy for hepatic conditions

A deep learning diagnostic system combining CT and ultrasound achieved superior accuracy in detecting hepatic echinococcosis and other liver conditions compared to individual modalities and physician evaluations. The integrated model demonstrated an impressive accuracy of 81.6% in internal tests and 84.9% in external assessments, with high sensitivity and specificity. This innovation significantly reduces misdiagnosis rates, showcasing the potential of multimodal imaging in improving diagnostic reliability in underserved healthcare settings.

Journal Article by Zhang J, Zhang J (…) Chen Y et 4 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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CPLX2 and SNAP25 genes are key in colorectal cancer liver metastasis

CPLX2 and SNAP25 have been identified as significant players in the progression of colorectal cancer liver metastasis. Researchers discovered that these genes are overexpressed in metastatic tissues compared to primary tumors. They also noted that these genes positively regulate the phosphatidylinositol 3-kinase-AKT signaling pathway. Through comprehensive analyses of gene expression and immune infiltration, 1,215 differentially expressed genes were identified, highlighting the potential of CPLX2 and SNAP25 as important molecular targets for treatment strategies in colorectal cancer.

Journal Article by Li X and Kang C in Medicine (Baltimore)

Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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