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Heterogeneity in outcome reporting impacts pancreatic surgery research

A systematic review of 156 studies on curative surgery for pancreatic adenocarcinoma reveals significant inconsistencies in outcome reporting. Researchers identified 2088 reported outcomes, resulting in 399 unique endpoints, with no single outcome universally reported. Alarmingly, 45% of these outcomes were undefined, indicating a lack of clarity. Most outcomes focused on adverse events and care delivery, leaving minimal emphasis on patient well-being post-surgery. This underscores the need for uniform definitions and a core outcome set to enhance future research.

Review by Britton E, Kobetic M (…) Rees J et 4 al. in HPB (Oxford)

Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Soluble TREM2 predicts liver dysfunction after surgery.

Soluble TREM2 (strem2) levels in plasma effectively reflect liver fibrosis status and predict postoperative liver dysfunction in patients undergoing liver resection. In a cohort of 108 patients assessed before surgery and on postoperative days one and five, strem2 demonstrated sensitivity for early, asymptomatic chronic liver disease. Notably, even patients without end-stage liver disease showed distinct strem2 levels based on fibrosis, enhancing early detection and potentially improving postoperative outcomes.

Journal Article by Santol J, Rajcic D (…) Hendrikx T et 13 al. in JHEP Rep

© 2024 The Author(s).

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Comprehensive Classification of Right Intrahepatic Portal Vein Branching

A study analyzing the branching patterns of the right intrahepatic portal vein identified 12 distinct types, emphasizing the anatomical variations of the right anterior and posterior portal veins. Three-dimensional visualization technology was utilized to analyze 711 patients, revealing the cranio-caudal and ventro-dorsal configurations among others. These findings provide clinicians with critical insights into portal vein anatomy, enhancing safety and decision-making in hepatic surgeries.

Journal Article by Luo W, Zeng X (…) Fang C et 5 al. in World J Surg

© 2025 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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Hospital programs can reduce violent injuries through better care access

Limited access to trauma care contributes to health disparities, particularly regarding violent injuries. Effective interventions, including hospital-based violence programs, can promote awareness and education within communities, supporting trauma-informed care. By prioritizing prevention and comprehensive access to care, healthcare professionals and policymakers can mitigate violence and enhance community health and safety. Addressing these gaps is essential to reducing trauma incidence and improving overall well-being for affected populations.

Journal Article by Arientyl V, Castater C, Hart L and Smith RN in Am Surg

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Adjuvant PD-1 inhibitors enhance survival in high-risk HCC patients.

In a study involving 199 hepatocellular carcinoma patients, the use of adjuvant PD-1 inhibitors significantly improved both recurrence-free survival (RFS) and overall survival (OS) rates. After propensity score matching, 1-year RFS was 87.1% for those receiving PD-1 inhibitors versus 44.6% for non-recipients, while 1-year OS rates were 98.5% versus 90.7%, respectively. The findings suggest that PD-1 inhibitors may effectively mitigate tumor recurrence and enhance survival outcomes post-hepatectomy.

Journal Article by Shen X, Yan W (…) Dong H et 3 al. in Eur J Med Res

© 2025. The Author(s).

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Surgical workload in Gaza reveals alarming trauma and infection rates

Surgical data from Al Aqsa Martyrs Hospital during the October 2023 conflict highlights over 2000 patients, with traumatic injuries constituting approximately 25% of cases. The most prevalent injuries were penetrating abdominal traumas, which demanded extensive surgical resources. A concerning 50% mortality rate was observed in patients presenting with class 4 hypovolemic shock, alongside a significant rise in infection rates in recent months. The findings underscore an urgent need for global medical intervention and humanitarian support.

Journal Article by Alasarr M, Awad M (…) Bsaiso H et 4 al. in East Mediterr Health J

Copyright: © Authors 2025; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
Copyright: © Authors 2025; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
Copyright: © Authors 2025; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).

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Deep learning model enhances bile duct identification during surgery

A newly developed deep learning system effectively identifies extrahepatic bile ducts in real-time during laparoscopic cholecystectomy. Trained on 3,993 images, the YoloV7 model achieved a mean average precision of 0.846 overall, with specific accuracies of 94.39% for the common bile duct and 84.97% for the cystic duct during video clip validations. By optimizing these crucial identifications, the model aims to significantly reduce the risk of bile duct injuries in surgical procedures.

Journal Article by Yin SM, Lien JJ and Chiu IM in BJS Open

© The Author(s) 2025. Published by Oxford University Press on behalf of BJS Foundation Ltd.

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Metabolic syndrome increases cholangiocarcinoma risk significantly.

A large-scale population-based cohort study involving 4,932,211 adults revealed that individuals with metabolic syndrome face a significantly heightened risk of cholangiocarcinoma, with a multivariate-adjusted hazard ratio of 1.20. During 35,879,371 person-years of follow-up, there were 6,117 identified cases, with incidence rates rising in correlation with the number of metabolic components. Those with five metabolic factors had a hazard ratio of 1.67. Effective management of metabolic syndrome may lower cholangiocarcinoma occurrence.

Journal Article by Chen TI, Chen MH (…) Lee MH et 11 al. in Hepatology

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Broad-spectrum penicillin antibiotics improve pancreatoduodenectomy outcomes

A systematic review involving 12,469 patients indicates that broad-spectrum penicillin-based antibiotics (bs-ab) notably reduce surgical site infections, postoperative pancreatic fistula rates, and mortality compared to standard cephalosporins. Specifically, bs-ab led to a 47% decrease in surgical site infections and a 38% reduction in postoperative pancreatic fistulas. Notably, benefits were enhanced for patients with preoperative biliary drainage. These findings suggest that bs-ab could serve as the new standard for antibiotic prophylaxis in pancreatoduodenectomy.

Journal Article by Harnoss JC, Halm D (…) Hank T et 10 al. in Ann Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Automated models enhance competency assessment in laparoscopic surgery

The study demonstrates the development of automated surgical action recognition models, achieving significant accuracy in competency prediction during laparoscopic cholecystectomy. Analysis of the cholec80 dataset revealed that high-competency groups exhibited shorter dissection durations and higher scores on established evaluation metrics. A random forest model achieved 93% accuracy in predicting surgical competency, while a video-masked autoencoder reached 89.11% accuracy in recognizing surgical actions. These advancements could transform surgical education by providing precise performance feedback.

Journal Article by Yen HH, Hsiao YH (…) Ho MC et 5 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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