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Implementing ERAS can significantly reduce hospital stay lengths

In Ethiopia, adherence to Enhanced Recovery After Surgery (ERAS) guidelines was achieved in 65.2% of cases among 555 patients reviewed. The study revealed that following all five ERAS recommendations led to a remarkable reduction of approximately 5 days in postoperative hospital length of stay (LOS), with early mobilization and prompt feeding showing consistent decreases across procedures. This indicates that even limited ERAS implementation can enhance recovery outcomes in resource-constrained environments.

Journal Article by Kifle F, Belay E (…) Biccard B et 7 al. in World J Surg

© 2025 The Author(s). World Journal of Surgery published by John Wiley & Sons Ltd on behalf of International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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Multi-angle suture training enhances laparoscopic skills

A novel multi-angle suture training module significantly improved the laparoscopic skills of surgical residents. In a study involving 36 second-year surgical residents, those trained with the multi-angle module completed laparoscopic end-to-end anastomosis surgeries faster (3375.7 s vs. 4678.2 s) and scored higher in surgical performance (8.2 vs. 6.83) compared to those using traditional training. These findings suggest that the multi-angle approach is superior for preparation in laparoscopic intestinal anastomosis.

Journal Article by Shen J, Wu C (…) Yang J et 2 al. in World J Emerg Surg

© 2025. The Author(s).

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Mortality from necrotizing fasciitis sharply increases in the U.S.

Between 2003 and 2020, necrotizing fasciitis (NF) deaths in the U.S. surged by 120.6%, from 824 to 1,842 annually. The age-adjusted mortality rate rose from 0.44 to 0.71 per 100,000 people. Males faced higher mortality overall, with a stark rise post-2015. American Indian or Alaska Native groups reported the highest rates, while regional disparities were evident, with the West experiencing the most deaths. Public health efforts are necessary to address healthcare inequities and improve outcomes.

Journal Article by Khan S, Ahmad R (…) Iqbal J et 6 al. in World J Surg

© 2025 The Author(s). World Journal of Surgery published by John Wiley & Sons Ltd on behalf of International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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Combined imaging improves accuracy for detecting liver metastases

Combining contrast-enhanced CT with MRI significantly boosts the detection of colorectal liver metastases, achieving sensitivity rates of 96.5% compared to 90.6% for MRI alone. Specificity also improved, from 95.3% to 98.3%. Notably, radiologists reported higher diagnostic confidence in 78.8% of cases with the combined approach, up from 64.7% with MRI alone. Additionally, inter-observer agreement reached an “almost perfect” level when using both imaging modalities, indicating substantial enhancements in diagnostic performance.

Journal Article by Zhang L and Bai L in BMC Gastroenterol

© 2025. The Author(s).

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Immunotherapy shows promise in treating gastric adenocarcinoma

Recent findings reveal that immune checkpoint inhibitors (ICIs) significantly improve treatment outcomes for advanced gastric adenocarcinoma (GAC), especially in patients with specific molecular subtypes such as MSI-H and HER2-positive. Combining ICIs with chemotherapy or targeted therapies enhances efficacy, despite the risk of immune-related adverse events (IRAEs). The study emphasizes the need for effective management strategies and future research to identify new therapeutic targets and personalize treatment approaches for improved safety and efficacy in GAC.

Review by Chen Z, Ma Y and Chen J in World J Surg Oncol

© 2025. The Author(s).

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New obesity treatments show promise in addressing weight loss challenges

Recent advancements in obesity treatment highlight new pipeline agents that effectively match weight loss results of surgery. Notably, GLP-1 analogs not only reduce weight but also improve obesity-related health issues. However, significant gaps remain, with alternative treatment options needed to address muscle mass loss and energy expenditure decline. Developing novel therapies, including myostatin inhibitors and combination treatments with glucagon agonists, aims to create more sustainable and tolerable obesity solutions while addressing severe comorbidities.

Review by Çetin E, Pedersen B and Burak MF in Turk J Med Sci

© TÜBİTAK.

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Immunotherapy shows promise for treating gastrointestinal cancers

Current strategies in immunotherapy for gastrointestinal cancers include immune checkpoint inhibitors, cytokine therapies, and novel approaches like CAR-T therapy. Clinical trials demonstrate significant benefits, although challenges such as immunosuppression and adverse effects remain. Future directions emphasize overcoming barriers, improving patient selection, and developing new treatments, including toll-like receptor-directed therapies. Ongoing research is essential to enhance the effectiveness of these immunotherapies and maximize patient outcomes.

Review by El Fil S, Uwishema O (…) Mshaymesh S et 3 al. in Ann Med Surg (Lond)

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Prognostic model predicts recurrence and treatment response in HCC

A novel prognostic model utilizing pathological signatures effectively predicts postoperative recurrence risk and sorafenib response in hepatocellular carcinoma (HCC) patients. Analyzed across 287 non-treated patients, the model achieved AUROC values of 0.818 and 0.811 for predicting one and two-year recurrence respectively. Validation with an external cohort confirmed its predictive power. Additionally, it successfully stratified sorafenib-treated patients, highlighting significant survival differences, thereby supporting clinical decision-making and enhancing patient stratification.

Journal Article by Li Y, Xiong J (…) Liu L et 5 al. in BMC Med

© 2025. The Author(s).

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Transarterial embolization effectively manages liver cancer hemorrhages

Transarterial embolization (TAE) demonstrates a 100% hemostasis success rate in treating ruptured hemorrhages and postablation bleeding in liver cancer patients. The 30-day survival rates were 90.91% for the rupture group and 100% for the ablation group, with 1-year survival rates of 45.45% and 85.19%, respectively. Although liver function changes occurred postoperatively, they remained comparable to controls. Monitoring alanine aminotransferase and total bilirubin is vital for early liver injury detection and timely interventions.

Journal Article by Gao W, Zhang Q (…) Yuan C et 3 al. in Transplant Proc

Copyright © 2025. Published by Elsevier Inc.

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Higher OLGA and OLGIM stages increase gastric cancer risk.

Higher stages of the OLGA and OLGIM staging systems significantly correlate with an elevated risk of developing high-grade dysplasia (HGD) and gastric cancer (GC). A systematic review and meta-analysis of eight prospective cohort studies found that moving from OLGA/OLGIM categories 0-II to III-IV notably increases the likelihood of these outcomes. This validates the use of these classification systems in evaluating gastric cancer risk and supports their role in developing endoscopic surveillance programs.

Journal Article by Benites-Goñi H, Cabrera-Hinojosa D (…) Riquelme A et 3 al. in Therap Adv Gastroenterol

© The Author(s), 2025.

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