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Surgery, IORT, and PVC Improve Survival for HCC Patients

A novel triple therapy combining surgery, intraoperative radiotherapy (IORT), and postoperative PVC significantly enhances survival for hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombosis (MPVTT). A retrospective study of 56 patients revealed the surgery-IORT-PVC group achieved superior median overall survival (not reached vs. 7 months) and median progression-free survival (not reached vs. 4 months) compared to the TACE-HAIC group. This approach offers a promising treatment option for patients facing limited alternatives.

Journal Article by Song Z, Li H (…) Shao Z et 11 al. in Eur J Surg Oncol

Copyright © 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

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Admission myoglobin predicts complications in trauma patients

Elevated myoglobin levels in trauma patients correlate significantly with the development of coagulopathy, systemic inflammatory response syndrome (SIRS), and acute kidney injury (AKI). In a study of 312 patients, myoglobin emerged as a notable independent risk factor for these complications, particularly AKI, with a predictive accuracy of 80.4%. The research underscores the importance of routine muscle injury indicator testing upon admission to enhance early detection and intervention in trauma care.

Journal Article by Mu L, Song H (…) Jiang N et 3 al. in World J Emerg Surg

© 2025. The Author(s).

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Single-layer pancreaticojejunostomy may lower complication rates

A meta-analysis of ten studies involving 1,811 patients found that single-layer pancreaticojejunostomy (PJ) is associated with a significantly reduced rate of clinically relevant postoperative pancreatic fistula (cr-popf) compared to double-layer PJ. The single-layer approach demonstrated a lower grade B popf rate and a consistent trend of reduced complications across various subgroups, including those defined by international criteria and minimally invasive techniques.

Systematic Review by Huang W, Wu Q (…) Wang L et 4 al. in Minerva Surg

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Predictive model enhances decision-making in gallbladder cancer surgeries

A study involving 788 gallbladder cancer patients identified key predictors of futile up-front surgery, defining futile cases as those resulting in early recurrence or death post-operation. Among patients, 13.6% experienced futile outcomes, with a stark median survival of 6.8 months versus 57.4 months for non-futile cases. Major risk factors included advanced tumor stage, lymph node involvement, and multivisceral resection. A robust predictive model was developed, optimizing patient selection to potentially reduce unnecessary surgeries.

Journal Article by Serenari M, Berti D (…) Vega EA et 34 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Behavioral health disorders increase opioid dependence post-surgery

A significant association was found between behavioral health disorders and new persistent opioid use following major surgeries. Among 62,585 patients studied, 20.3% with behavioral health disorders developed persistent opioid use compared to 16.6% without. This group also required higher median morphine doses. Additionally, those with behavioral health disorders had 32% greater odds of developing new opioid dependence. These findings highlight the complex relationship between mental health and opioid management in surgical patients.

Journal Article by Rashid Z, Macedo AB (…) Pawlik TM et 8 al. in BMC Surg

Copyright © 2025 Elsevier Inc. All rights reserved.

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New prognostic score improves survival predictions in gastric cancer

A novel prognostic oxidative stress-immune-inflammation score (posii score) has been developed to enhance survival predictions for gastric cancer patients post-radical gastrectomy. Analysis of 3,612 patients revealed that those in the low posii group exhibited significantly higher 5-year overall and disease-free survival rates, along with reduced recurrence risks (p < 0.05). Two validated online calculators based on the posii score can aid clinicians in individualized prognostic assessments, providing crucial insights into treatment and management strategies.

Journal Article by Zheng H, Zheng H (…) Li P et 12 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Neoadjuvant immunochemotherapy shows promising outcomes in esophageal cancer.

A multicenter retrospective study evaluated neoadjuvant immunochemotherapy involving PD-1 agents plus platinum-based chemotherapy for 213 patients with resectable esophageal cancer. The study reported a high pathological complete response (PCR) rate of 31.9%, with a complete tumor resection (R0) rate of 99.1%. Additionally, two-year disease-free survival (DFS) and overall survival (OS) rates were notable at 78.9% and 80.9%, respectively, highlighting the treatment’s efficacy and manageable toxicity.

Multicenter Study by Lan K, Yan X (…) Zhao J et 17 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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High accuracy in predicting clean common bile ducts

A study involving 584 acute biliary pancreatitis patients revealed that age, gamma-glutamyl transferase, alkaline phosphatase, and direct bilirubin levels significantly correlate with choledocholithiasis presence. The determined cut-off values indicated a 97% negative predictive value for a clean common bile duct when all four parameters were below thresholds. Consequently, unnecessary imaging could be minimized, leading to reduced costs and risks associated with unnecessary procedures while ensuring patient safety during follow-up.

Journal Article by Çelik A, Ertekin C (…) Gök AFK et 6 al. in Ulus Travma Acil Cerrahi Derg

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Laparoscopic navigation improves outcomes in liver surgery

Laparoscopic portal territory fluorescence navigation-guided anatomical liver resection (LPTAR) outperforms classic anatomical resection (CAR) for hepatocellular carcinoma (HCC) patients. In a study of 234 patients, those undergoing LPTAR demonstrated significantly wider resection margins, reduced blood loss, and fewer postoperative complications compared to CAR. Furthermore, the recurrence-free survival rates at 1, 3, and 5 years were notably higher in the LPTAR group, highlighting its clinical effectiveness and safety.

Journal Article by Wang AZ, Zhou R (…) Cao J et 4 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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EBV positivity improves survival rates in gastric cancer patients

In a multicenter study, significant differences in long-term survival were observed between patients with Epstein-Barr virus-associated gastric cancer (EBVAGC) and those with Epstein-Barr virus-negative gastric cancer (EBVNGC) after radical gastrectomy. The 3-year overall and disease-free survival rates were notably higher in the EBVAGC group. Additionally, positivity for Epstein-Barr virus-encoded small RNA served as an independent predictor of survival, and it’s essential for stage II and III patients to receive at least four cycles of chemotherapy postoperatively.

Journal Article by Xie RZ, Huang ZN (…) Li P et 8 al. in Eur J Surg Oncol

Copyright © 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

read the whole article in Eur J Surg Oncol

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