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Completion of two-stage hepatectomy improves survival outcomes for patients

In a retrospective analysis involving 183 colorectal liver metastasis patients, 69% completed two-stage hepatectomy (tsh), achieving a median overall survival of 65.3 months compared to just 20.6 months for those who failed to complete it. The study identified key prognostic factors linking successful resections to lower rates of extrahepatic disease, tumor size over 5 cm, and better chemotherapy responses. TSH coupled with perioperative systemic therapies significantly enhances long-term outcomes.

Journal Article by Boerner T, Gagnière J (…) D’Angelica MI et 11 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Laparoscopic hepaticoduodenostomy proves effective for bilioenteric reconstruction

Laparoscopic hepaticoduodenostomy (LHD) has emerged as a viable alternative to traditional Roux-en-Y hepaticojejunostomy for bilioenteric reconstruction. In a study involving 125 patients, LHD was successfully performed in 91.5% of cases with cholangiocarcinoma and 54.9% for benign biliary strictures. Key metrics included a mean operative time of 210 minutes, a hospital stay averaging six days, and an 8% incidence of postoperative bile leaks. Overall, LHD demonstrated safe, feasible, and acceptable outcomes.

Journal Article by Choudhary D, Vageesh BG, Javed A and Agarwal AK in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Technology could improve surgical access in rural areas

Surgical care access in rural America is hindered by geographic and infrastructure challenges. Innovative technologies such as telehealth and remote monitoring can enhance preoperative and postoperative support while mitigating travel burdens. However, limited broadband and reimbursement issues pose significant barriers to implementation. Federal programs like the BEAD initiative aim to bridge these gaps, yet tailored strategies and policy advocacy are crucial for broad adoption. Addressing these hurdles could significantly improve surgical outcomes in underserved communities.

Journal Article by Gillaspie EA, Shipman SA (…) Wong SL et 2 al. in World J Surg

© 2025 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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Tongue features enhance early detection of gastric cancer.

A novel non-invasive diagnostic model integrating traditional Chinese medicine tongue features with machine learning shows significant potential for early gastric cancer detection. An analysis of 292 participants revealed distinct tongue characteristics associated with gastric cancer, including bluish-purple and cracked appearances. The Gradient Boosting Decision Tree model demonstrated exceptional performance, achieving an AUC of 0.980. This approach not only highlights the viability of non-invasive methods but also promises to improve early diagnosis in resource-constrained settings.

Journal Article by Tian P, Chen Z (…) Lu M et 3 al. in Eur J Surg Oncol

Copyright © 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

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Both surgical approaches yield similar safety for colon cancer

A comparative analysis of the inferior approach (IA) versus medial approach (MA) in right-sided colon cancer surgery revealed no significant differences in postoperative complications or mortality between the two methods. In a study of 528 cases, safety was maintained across both approaches, with IA resulting in a significantly shorter hospital stay. Overall, both IA and MA are feasible options, allowing surgeons to choose based on personal preference while ensuring effective outcomes.

Comparative Study by Izukawa S, Numata M (…) Saito A et 11 al. in Tech Coloproctol

© 2025. The Author(s).

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Exosomal biomarkers effectively detect early-stage gastric cancer

The DESTINEX study reveals a revolutionary approach to early gastric cancer detection through a 17-microRNA signature. With an impressive diagnostic performance of 96.3% and 95.3% area under the curve (AUC) in training and validation cohorts, this method could significantly enhance screening practices. Notably, the 10-microRNA DESTINEX signature demonstrated a 96.8% AUC for identifying early-stage cases, offering a noninvasive alternative to traditional endoscopy, ultimately aiming to reduce mortality from delayed diagnoses.

Journal Article by Sui S, Xu C (…) Goel A et 10 al. in JAMA Surg

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Reduced reliance on percutaneous cholecystostomy improves outcomes

A quality improvement initiative across eight teaching hospitals significantly reduced percutaneous cholecystostomy usage for acute calculous cholecystitis, dropping from 9.7% to 7.2%. Post-implementation data indicated a decrease in 30-day mortality (odds ratio 0.60) and increased laparoscopic cholecystectomy rates (94.5% to 96.3%). Although minor bile duct leaks rose from 0.9% to 2.1%, no major duct injuries were reported. This structured pathway illustrates a trend towards safer surgical interventions with better outcomes.

Journal Article by Gross AR, Littau M (…) Miller BT et 8 al. in BMC Surg

Copyright © 2025 Elsevier Inc. All rights reserved.

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Endoscopic resection proves safe for early-stage duodenal tumors

In a comprehensive review of 40 patients with grade 1-2 duodenal neuroendocrine tumors, endoscopic resection emerged as a viable first-line treatment option. Notably, ligation-assisted endoscopic mucosal resection achieved a remarkable 100% complete resection rate, with only one case of perforation successfully managed endoscopically. During a mean follow-up of nearly five years, no patients experienced metastasis or tumor recurrence, highlighting the procedure’s potential in avoiding unnecessary surgical interventions in selected cases.

Journal Article by Lee CM, Choi CW (…) Hwang SH et 7 al. in Scand J Gastroenterol

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Procedural interventions yield high success rates in Rwanda

A study of 158 patients with obstructive jaundice in Rwanda revealed endoscopic retrograde cholangiopancreatography (ERCP) as the predominant intervention, achieving a technical success rate of 79.44%. Overall, procedural success reached 82.61%, with percutaneous transhepatic biliary drainage (PTBD) at 91.67% and surgical procedures at 100%. The 30-day survival rate was 92.41%. Notably, weight loss and ICU admission increased mortality risk, while timely interventions reduced it significantly.

Journal Article by Ingabire Z, Hanna AB (…) Berhane R et 9 al. in BMC Gastroenterol

© 2025. The Author(s).

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Minimally invasive modalities are transforming pancreatic cancer palliation

Unresectable pancreatic cancer, with a bleak 5-year survival rate of 13.3%, has prompted a shift from traditional surgical interventions to innovative minimally invasive techniques. Researchers detail the evolution from open surgeries to procedures like endoscopic stent placement and percutaneous biliary drainage, improving patient quality of life. Advances such as lumen-apposing metal stents are facilitating key palliative solutions for managing complications like obstructive jaundice and gastric outlet obstruction, offering new hope in this aggressive disease landscape.

Review by Masood M, Irani S (…) Kozarek RA et 3 al. in J Clin Med

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