Blog

Mature tertiary lymphoid structures indicate better prognosis in colorectal cancer.

Post author By STITCHES Newsletter
Post date 14/12/2024
Categories In General Surgery, Intestine and Lower Gastrointestinal Tract

Colorectal cancer patients with mature tertiary lymphoid structures (TLS) demonstrated notably improved outcomes, including reduced rates of vascular tumor thrombus, lymph node, and liver metastasis. An analysis of 230 specimens revealed that mature TLS correlated with lower Ki-67 expression and higher levels of deficient mismatch repair and PD-L1 positivity. These findings suggest that TLS maturation plays a crucial role in patient prognosis and may inform strategies for immunotherapy and prognostic evaluations in colorectal cancer.

Journal Article by Zheng J, Yu J (…) Deng H et 2 al. in Zhejiang Da Xue Xue Bao Yi Xue Ban

read the whole article in Zhejiang Da Xue Xue Bao Yi Xue Ban

open it in PubMed

Deep-learning model predicts hepatocellular carcinoma recurrence effectively

Post author By STITCHES Newsletter
Post date 13/12/2024
Categories In Digital Surgery and Telemedicine, General Surgery, HPB & Spleen

A novel deep-learning model, Recurr-Net, significantly outperformed traditional methods in predicting hepatocellular carcinoma (HCC) recurrence post-curative surgery. Analyzed across 1,231 patients, Recurr-Net demonstrated an area under the receiver operating characteristic curve (AUROC) of 0.770 to 0.857 internally and 0.758 to 0.798 externally, while the historical microvascular invasion (MVI) showed much lower performance. This indicates Recurr-Net’s potential for superior pre-operative prognostication, crucial for risk stratification in HCC management.

Journal Article by Hui RW, Chiu KW (…) Seto WK et 17 al. in Hepatology

read the whole article in Hepatology

open it in PubMed

Multisocietal consensus supports CRS and HIPEC for DMPM patients

Post author By STITCHES Newsletter
Post date 13/12/2024
Categories In Cytoreductive Surgery & Peritoneum, General Surgery

A multisocietal consensus has endorsed cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for treating diffuse malignant peritoneal mesothelioma (DMPM). An expert panel, acknowledging the limited efficacy of systemic chemotherapy, strongly recommended this approach for a select subgroup of patients. Despite low evidence certainty, the panel emphasized the potential for improved survival outcomes with CRS-HIPEC, advocating for broader acceptance and centralized care for this rare and aggressive cancer.

Journal Article by Kusamura S, Cinquini M (…) Marcello D et 11 al. in J Surg Oncol

read the whole article in J Surg Oncol

open it in PubMed

Female patients less likely to receive opioid-sparing regimens

A study examining pain management in ventral hernia repair found that female patients were less likely than male patients to receive an opioid-sparing regimen despite showing a higher analgesic response and lower morphine consumption postoperatively. Specifically, only 62.27% of females were offered opioid-sparing pain regimens compared to 66.34% of males. The analysis revealed an odds ratio of 0.647 for female patients receiving these regimens, underscoring the need for increased awareness of sex-specific pain management differences among clinicians.

Journal Article by Satija D, Dai J (…) Renshaw S et 5 al. in J Surg Res

read the whole article in J Surg Res

open it in PubMed

Pressure injury prediction model developed for Da Vinci surgery patients

Post author By STITCHES Newsletter
Post date 13/12/2024
Categories In General Surgery, Perspectives, Opinions and Curiosities, Wounds

A study analyzing 335 patients undergoing Da Vinci surgery revealed that 195 experienced pressure injuries, identifying key risk factors including age, surgery duration, BMI, and the presence of a nasogastric tube. Through logistic regression analysis, researchers established a reliable prediction model to assess pressure injury risk in these patients. This model demonstrates effective assessment capabilities, highlighting its potential role in improving patient outcomes and minimizing hospital resource use for at-risk surgical patients.

Journal Article by Shen Y, Huang P (…) Luo J et 5 al. in Int J Med Robot

read the whole article in Int J Med Robot

open it in PubMed

Primary needle-knife fistulotomy is safer for biliary access.

Post author By STITCHES Newsletter
Post date 13/12/2024
Categories In General Surgery, HPB & Spleen, Surgical Endoscopy

A randomized clinical trial involving 260 patients revealed that primary needle-knife fistulotomy (PNKF) significantly outperforms standard transpapillary (STP) techniques for cannulating long-size papilla. PNKF achieved a biliary cannulation success rate of 96.2% compared to STP’s 87.7% (p = 0.01). Moreover, post-endoscopic retrograde cholangiopancreatography pancreatitis was markedly lower in the PNKF group (2.4%) versus STP (9.6%, p = 0.02), alongside fewer attempts and faster cannulation times.

Journal Article by Sadeghi A, Arabpour E (…) Zali MR et 5 al. in Clin Transl Gastroenterol

read the whole article in Clin Transl Gastroenterol

open it in PubMed

Laparoscopic liver resection proves cost-effective

Post author By STITCHES Newsletter
Post date 12/12/2024
Categories In General Surgery, HPB & Spleen

Laparoscopic liver resection (LLR) demonstrated superior clinical and economic outcomes compared to open liver resection (OLR) in a study involving 920 patients. LLR resulted in significantly fewer postoperative transfusions, a shorter median length of stay, and lower rates of complications, readmissions, and reoperations. Importantly, LLR showed lower total costs across all types of hepatectomies, establishing it as a dominant strategy with a high probability of being cost-effective, indicating substantial savings in the surgical treatment of liver conditions.

Journal Article by Koh YX, Zhao Y (…) Goh BKP et 7 al. in J Am Coll Surg

read the whole article in J Am Coll Surg

open it in PubMed

Deep learning model effectively predicts mismatch repair deficiency in colorectal cancer

Post author By STITCHES Newsletter
Post date 12/12/2024
Categories In Digital Surgery and Telemedicine, General Surgery, Intestine and Lower Gastrointestinal Tract

A new deep learning model demonstrated strong predictive capabilities for mismatch repair deficiency in colorectal cancer. An area under the receiver operating characteristic (AUROC) score of 0.948 was achieved during testing, while independent validation yielded an AUROC of 0.807. Notably, the model achieved a negative predictive value of 94.2%. In a prospective trial, it accurately identified 29 out of 33 deficient tumors, suggesting its potential as an automatic screening tool for clinicians.

Journal Article by Cai Y, Chen X (…) Hu J et 6 al. in Surg Endosc

read the whole article in Surg Endosc

open it in PubMed

Surgical technique influences risk of gastroesophageal reflux after surgery

Post author By STITCHES Newsletter
Post date 12/12/2024
Categories In General Surgery, Metabolic and Bariatric Surgery

Surgical techniques during laparoscopic sleeve gastrectomy significantly affect the development of gastroesophageal reflux disease (GERD). Analyzing 7,435 patients, the study found that using a narrower bougie size and resecting further from the pylorus increased the likelihood of requiring proton pump inhibitors (PPIs) post-surgery. Advanced age and female sex were identified as independent risk factors for GERD symptoms, while factors like initial BMI and total weight loss did not show significant correlations.

Journal Article by Al-Tai S, Axer S (…) Stenberg E et 2 al. in Surg Obes Relat Dis

read the whole article in Surg Obes Relat Dis

open it in PubMed

Enhanced recovery after colorectal surgery significantly improves patient outcomes

Post author By STITCHES Newsletter
Post date 12/12/2024
Categories In General Surgery, Intestine and Lower Gastrointestinal Tract

A study on enhanced recovery after surgery (ERAS®) revealed notable improvements in patient recovery post-elective colorectal surgery. Patients in cohorts following ERAS® implementation experienced significantly higher rates of bowel movement and solid food intake, with 98% achieving bowel movements by discharge compared to only 66% prior. Additionally, opioid use decreased significantly, and cohort C reported a 90% recovery rate upon discharge. These findings underscore the effectiveness of ERAS® in enhancing early mobility and overall recovery.

Comparative Study by Knab K, Aurnhammer L (…) Hardt J et 5 al. in Int J Colorectal Dis

read the whole article in Int J Colorectal Dis

open it in PubMed