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Multidisciplinary team meetings significantly impact pancreatic cancer care

Evidence from 36 studies reveals that multidisciplinary team meetings (MDMs) for pancreatic cancer significantly affect care decisions, influencing initial diagnoses in 3.4%-21.7% of cases and altering treatment plans in 18.2%-72.2%. These meetings improve clinical trial participation but incur substantial preparation time (16.5 hours weekly) and financial costs ($240 per case). Best practices suggest standardization and leveraging emerging technologies to enhance data collection and patient identification for clinical trials, highlighting the critical need for cost-effective workflows.

Review by Sabmeethavorn QW, Sylivris A (…) Loveday BPT et 4 al. in ANZ J Surg

© 2025 Royal Australasian College of Surgeons.

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Biliary stenting with 125I seeds enhances survival and stent patency.

A meta-analysis of 14 studies involving 1,078 patients indicates that biliary stenting combined with intraluminal 125I seed brachytherapy significantly improves overall survival and stent patency compared to standard biliary stenting alone. The study found no increase in complications or severe liver damage associated with the combined treatment. With longer survival and better functionality of the stent without adverse effects, clinicians may consider this approach as a safe and effective option for advanced cholangiocarcinoma patients.

Journal Article by Chen ML, Wang XL (…) Wang YB et 3 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Reinforcement sutures significantly lower risk of anastomotic leakage.

A meta-analysis found that using reinforcement sutures during double-stapling anastomosis in rectal cancer surgery effectively reduced the incidence of anastomotic leakage (AL) and reoperation rates. The analysis included one randomized controlled trial and eight observational studies, yielding an odds ratio of 0.29 for AL, indicating a substantial decrease in risk. Although promising, the findings underscore the need for larger-scale randomized controlled trials to further validate these benefits and assess long-term efficacy.

Review by Tamura K, Fujimoto T (…) Nakamura M et 8 al. in Surg Today

© 2025. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.

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New machine learning model predicts cholangitis risk after ERCP

A novel interpretable machine learning model has been developed to predict post-ERCP cholangitis (PEC) in patients with malignant biliary obstruction (MBO). The model, utilizing data from 2831 patients, identified key risk factors including radiofrequency ablation and white blood cell count. Among various machine learning methods, the XGBoost model outperformed others, predicting PEC risk with accuracy metrics of AUC 0.7670 and AUC 0.7270 in internal and external cohorts, respectively, thus aiding clinicians in tailoring individualized treatment plans.

Journal Article by Jin H, Sun X (…) Liu K et 8 al. in Surg Endosc

© 2025. The Author(s).

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Essential Variables for Trauma Registries in Low-Middle-Income Countries Identified

A Delphi survey revealed 37 essential variables for adult trauma registries in low-middle-income countries, with demographic data, injury details, and clinical assessments leading the list. Following a two-round expert consensus process, additional optional variables emerged, including education and income levels. Birthplace was excluded. These insights aim to enhance trauma care in resource-constrained settings, emphasizing the importance of establishing effective trauma systems for improved patient outcomes in areas with high morbidity and mortality rates.

Journal Article by Farhat T, Di Marco S (…) Deckelbaum D et 8 al. in World J Surg

© 2025 The Author(s). World Journal of Surgery published by John Wiley & Sons Ltd on behalf of International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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Preoperative weight loss lowers pancreatic fistula risk after surgery

In a study of 43,126 patients who underwent pancreatectomy, 16.3% developed postoperative pancreatic fistula (POPF). Preoperative weight loss correlated with reduced odds of developing POPF (odds ratio 0.87), whereas higher body mass index (BMI) increased risk. For patients experiencing weight loss, each BMI point increase resulted in a 67% rise in POPF odds, contrasting with a mere 4.3% for those without weight loss. This indicates that weight management significantly affects surgical outcomes.

Journal Article by Sun J, Hwang J (…) Reddy SS et 5 al. in J Gastrointest Surg

Copyright © 2025. Published by Elsevier Inc.

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New nomogram predicts survival for signet ring cell gastric cancer patients

A novel prognostic nomogram has been developed for predicting overall survival (OS) and cancer-specific survival (CSS) in signet ring cell gastric cancer patients post-surgery. Analyzing data from 3,481 patients, researchers identified critical independent prognostic factors, including race, chemotherapy, and lymph node ratio. The nomogram demonstrated impressive accuracy with a c-index of 0.748 for OS and 0.763 for CSS. Validation cohorts also showed strong predictive performance, suggesting the nomogram could significantly aid personalized treatment decisions.

Journal Article by Peng C and Li T in J Gastrointest Oncol

Copyright © 2025 AME Publishing Company. All rights reserved.

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New framework established for safe telesurgery implementation

A comprehensive framework developed by the Society of Robotic Surgery outlines best practices for effective and ethical telesurgery. This initiative drew on extensive literature reviews and expert consensus from various disciplines. Key considerations encompass technological requirements, safety standards, training protocols, and legal issues. By promoting scalable implementation and addressing regional regulations, the framework aims to serve as an essential reference for institutions and policymakers to enhance the safety and efficacy of telesurgery globally.

Review by Patel V, Saikali S (…) Moschovas M et 28 al. in J Robot Surg

© 2025. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

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New tool predicts perforation risks during endoscopic submucosal dissection

A novel predictive model for perforation risk during endoscopic submucosal dissection (ESD) has been developed and validated by researchers. In a study involving 1,051 patients, significant predictors included the first 100 procedures, lesion size over 35 mm, and extended operative time. The model demonstrated satisfactory validation performance with an area under the curve of 0.7078 and accuracy of 80.19%. This tool aims to enhance patient safety and inform preprocedural strategies for clinicians.

Journal Article by Ulkucu A, Laporte M (…) Gorgun E et 4 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Machine learning excels at predicting post-pancreaticoduodenectomy hemorrhage

A machine learning model significantly improves risk stratification for post-pancreaticoduodenectomy hemorrhage (pph), identifying eight key predictors such as albumin levels and operative time. With an area under the curve (AUC) of 0.84 during training and 0.82 in validation, this model outperformed traditional logistic regression, enabling clinicians to classify patients into low, medium, and high-risk groups effectively. The deployment of this model as an interactive tool aids in the proactive management of at-risk patients.

Validation Study by Zhang Z, Zhao X (…) Gu Z et 5 al. in BMJ Open

© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.

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