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Multimodal nomogram enhances assessment of gastric cancer invasion depth

A combined nomogram integrating IVIM-DWI parameters and MRI characteristics achieved AUC values of 0.901 and 0.883 in training and validation cohorts, respectively. This approach effectively distinguishes between T1-2 and T3-4 stages of gastric cancer, addressing the challenge faced by radiologists in preoperative assessments. No significant difference was found between individual models, indicating the multimodal approach’s superiority in predicting tumor invasion depth and guiding neoadjuvant chemotherapy selection.

Journal Article by Hong Y, Li X (…) Zeng Q et 6 al. in Eur J Med Res

© 2024. The Author(s).

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Adjuvant therapy improves recurrence-free survival in HCC patients

Camrelizumab plus apatinib in a real-world setting has shown significant benefits in recurrence-free survival (RFS) for patients with hepatocellular carcinoma (HCC) with microvascular invasion following radical resection. The comparison between adjuvant therapy (99 patients) and observation (172 patients) indicated a hazard ratio of 0.52 for RFS improvement (p<0.001). However, overall survival did not significantly differ (hazard ratio 0.62; p=0.079). Grade 3 or 4 treatment-related adverse events occurred in 20.7% of treated patients.

Journal Article by Ouyang J, Yang Y (…) Zhao H et 8 al. in Hepatobiliary Surg Nutr

2024 Hepatobiliary Surgery and Nutrition. All rights reserved.

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3D virtual modelling enhances safety in laparoscopic colon surgery

Validation of 3D virtual modelling (3DVM) demonstrated a 96% accuracy for identifying arteriovenous variations in laparoscopic complete mesocolic excision with central vascular ligation (CMECVL) among 26 patients. Compared to 49 standard mesocolic excision controls, CMECVL showed no intraoperative complications and similar 30-day morbidity rates, although intraoperative times were longer initially. Aimed at improving surgical safety, 90% of surveyed stakeholders endorsed the utility of 3DVM, signifying its value in the surgical workflow.

Journal Article by Kearns EC, Moynihan A (…) Cahill RA et 13 al. in Eur J Surg Oncol

Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Sugarbaker technique shows lower recurrence in parastomal hernia repair

Findings from a retrospective analysis of 81 patients reveal a 25.9% recurrence rate and a 16.0% complication rate for large parastomal hernia repairs using lap-re-do techniques. Notably, the lap-re-do Sugarbaker technique demonstrated a significantly lower recurrence rate of 12.2% compared to 40% for the Keyhole technique. Complication and reoperation rates were also more favorable with Sugarbaker at 19.5% and 4.9%, respectively, indicating its superiority in managing these complex cases.

Journal Article by Fu X, Li M, Hua R and Yao Q in Hernia

© 2024. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.

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Robotic-assisted NOSE offers superior outcomes in colorectal surgery

This meta-analysis compared robotic-assisted natural orifice specimen extraction (NOSE) with traditional robotic transabdominal wall specimen retrieval (TWSR) in colorectal cancer surgeries involving 717 patients. Findings revealed that the NOSE technique resulted in significantly lower overall postoperative complications (OR 0.55; p=0.01) and indicated its safety and effectiveness as an alternative to TWSR. Enhanced recovery metrics were observed, supporting NOSE’s favorable outcomes for patients. Further large-scale studies are recommended to confirm these results.

Systematic Review by Zhan S, Zhu Z (…) Wan Z et 3 al. in BMC Surg

© 2024. The Author(s).

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Computer vision algorithm outperforms experts in predicting SMA margin status.

A computer vision algorithm was developed to predict superior mesenteric artery (SMA) margin status in pancreatic ductal adenocarcinoma patients using preoperative CT scans. In a study involving 200 patients, the algorithm achieved a sensitivity of 0.43, outperforming radiologists (0.23) and surgeons (0.36). Specificity was high across the board, with both the algorithm and a radiologist achieving 0.94. Overall accuracy for the algorithm was 0.85, surpassing radiologists (0.80) and surgeons (0.76), indicating significant potential for clinical application.

Journal Article by Wang J, Ashraf Ganjouei A (…) Alseidi A et 15 al. in Ann Surg

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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Preoperative hypoalbuminemia increases mortality and complications post-esophagectomy.

Preoperative hypoalbuminemia is linked to higher 30-day mortality and complications after esophagectomy. In a study involving 803 patients with hypoalbuminemia compared to 7046 controls, matched analyses revealed mortality rates of 4.48% for those with low albumin versus 3.00% for those without. Findings suggest that recognizing and addressing preoperative hypoalbuminemia may be a cost-effective risk stratification tool, potentially reducing adverse postoperative outcomes in esophagectomy patients.

Journal Article by Li R and Zhu Y in Am Surg

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CT-based radiomics model effectively predicts fibrosis in PDAC patients

The study established tumor fibrosis as an independent prognostic factor for survival in pancreatic ductal adenocarcinoma (PDAC) patients, identifying a 40% collagen fraction cut-off value crucial for prognosis differentiation. Utilizing a CT-based radiomics model, researchers achieved areas under the curve of 0.825 and 0.745 in training and test cohorts, respectively, outperforming traditional models in predicting fibrosis. These findings support the non-invasive assessment of tumor characteristics to guide treatment strategies.

Journal Article by Shi S, Liu R (…) Feng ST et 8 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Complete pathologic response significantly enhances survival in esophageal adenocarcinoma

Achieving complete pathologic response in esophageal adenocarcinoma is linked to a notable survival benefit. Among 16,169 patients analyzed, 11.4% achieved this response, rising to 17.5% in those diagnosed from 2016 to 2020. Key independent predictors included female sex, black race, Hispanic ethnicity, and clinical stage II disease, while clinical stage III correlated with lower response probabilities. Median survival was 86.4 months for responders versus 30.7 months for non-responders, highlighting critical prognostic implications.

Journal Article by Donato BB, Campany ME (…) D’Cunha J et 5 al. in Dis Esophagus

© The Author(s) 2024. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Colorectal cancer imposes significant economic burdens on society.

A systematic review of 37 studies highlights that colorectal cancer incurs substantial direct and indirect costs, primarily driven by direct medical expenses such as hospitalization, surgery, and chemotherapy. Face significant financial impacts are experienced by families, the health system, and broader society. The findings advocate for preventive measures and lifestyle modifications to alleviate this economic burden, along with expanded screening programs as a strategy for policymakers to impose cost limitations.

Journal Article by Jafari A, Hosseini FA and Jalali FS in Health Sci Rep

© 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.

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