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Flot Outperforms Cross in Esophageal Adenocarcinoma Survival

Flot chemotherapy shows a clear survival advantage over the Cross protocol for esophageal adenocarcinoma, impacting treatment choices.

  • Esopec trial: median overall survival (OS) for Flot at 66 months vs. 37 months for Cross (HR: 0.70, p=0.01).
  • Real-world data: Cross cohort median OS at 33.7 months, with a higher pathological complete response (PCR) of 20.5% versus 10.1% in Cross from Esopec.

Surgeons should tailor treatment based on fitness, tumor location, and toxicity, while emphasizing standardized PCR assessment to integrate trial and real-world outcomes.

Journal Article by Burri P, Chatziisaak S, Wolf S and Chatziisaak D in Eur J Surg Oncol

Copyright © 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

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Neoadjuvant Therapy Duration Impacts Pancreatic Cancer Surgery

Shorter neoadjuvant therapy (≤8 weeks) boosts surgical success in pancreatic cancer.

  • Surgical resection rate significantly higher with ≤8 weeks (66.7%) versus >8 weeks (33.5%).
  • This trend holds for both resectable (73.9% vs 44.7%) and borderline resectable cases (66.4% vs 22.5%).

Longer therapy does not improve resection margins or survival, suggesting risks in delaying surgery.

  • No significant differences in R0 resection, response rates, or 1- to 5-year survival rates between the two duration groups.

Journal Article by Hajibandeh S, Hajibandeh S (…) Roberts KJ et 6 al. in HPB (Oxford)

Copyright © 2025 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

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Prognostic Value of C-Reactive Protein-Triglyceride-Glucose Index in Gastric Cancer

Higher levels of the C-reactive protein-triglyceride-glucose index indicate worse outcomes after radical gastrectomy for gastric cancer.

  • Patients with a low cti had significantly longer disease-free survival (DFS) compared to those with high cti.
  • The hazard ratio for high cti predicting poor outcomes is 2.07.

Consider using cti and prognostic nutritional index (PNI) for better patient stratification and personalized treatment planning.

  • Both cti and PNI are independent prognostic factors for overall survival and DFS after surgery.

Journal Article by Hao QL, Yao ZY (…) Gao C et 5 al. in World J Gastrointest Oncol

©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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Cryoablation Shows Promise for Locally Advanced Pancreatic Cancer

Cryoablation is a safe and effective treatment for locally advanced pancreatic cancer (LAPC), enhancing patient outcomes when surgery isn’t feasible.

  • No perioperative deaths; smooth surgeries across all patients.
  • Postoperative pancreatic fistulas occurred in 75% of cases, but most were manageable.

This technique can prolong survival and improve quality of life by addressing tumor progression directly.

  • 12.5% experienced delayed gastric emptying; CA 19-9 levels stayed low at 30 days post-op.

Consider cryoablation as a key option in multidisciplinary care for LAPC patients.

Journal Article by Kang LM, He XL (…) Zhang FW et 7 al. in World J Gastrointest Oncol

©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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Improved Prediction of Lymph Node Metastasis in Pancreatic Cancer

Integrating the neutrophil-albumin ratio with multi-phase CT enhances lymph node metastasis detection in pancreatic cancer patients.

  • A model combining a neutrophil-albumin ratio greater than 0.13 and certain CT findings accurately identifies patients at high risk for lymph node metastasis before surgery.
  • Among 129 patients studied, factors like tumor size and hemangioma thrombosis also showed significant differences related to metastasis risk.

Using this predictive model can refine patient selection for curative surgery, potentially improving outcomes.

Journal Article by Wang H, Fu TY (…) Sun ZW et 2 al. in World J Gastrointest Oncol

©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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Supportive Care Yields Better Outcomes in Low Rectal Cancer Surgery

Integrating psychosocial, sleep, and nutritional support boosts recovery and survival after low rectal cancer resection.

  • Patients receiving integrated support had a 90.3% disease-free survival at 2 years compared to 79.2% for standard care (p = 0.028).
  • Their overall survival improved to 93.6% vs. 82.5% (p = 0.019).

Consider integrating these supportive interventions into surgical practice to enhance patient outcomes and recovery.

  • Postoperative inflammatory markers were significantly lower in the intervention group (p < 0.001).

Journal Article by Wang G and Pan S in Am J Surg

Copyright © 2025 Elsevier Inc. All rights reserved.

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Variation in Colorectal Cancer Outcomes Demands Action

Recurrence rates for colorectal cancer vary widely between institutions, showing a significant impact on surgical follow-up strategies.

  • Hospital C had the highest recurrence rate at 26.2%, while Hospital A had the lowest at 11.4%.
  • Most recurrences (80%) happened within 3 years, with a median time to recurrence of 1.6 years.

Improving surveillance adherence is crucial; overall adherence was only 45%, with non-adherence rates reaching 55.6% at Hospital C.

  • Five-year cancer-specific survival was only 68.3% at Hospital C compared to higher rates at other hospitals.

Journal Article by Thong DW, Newell N and Theophilus M in ANZ J Surg

© 2026 Royal Australasian College of Surgeons.

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Nurse-led clinic improves outcomes for LARS after colorectal surgery

A nurse-led outpatient clinic for low anterior resection syndrome (LARS) post-colorectal surgery significantly enhances patient quality of life.

  • Median LARS scores dropped from 38.0 to 13.0, with 76% moving from major to no LARS.
  • Wexner scores improved from 11.0 to 2.0, and global quality of life rose from 66.7 to 83.3.

Implementing structured treatments can lead to better management and outcomes for colorectal surgery patients.

  • 93% of patients received pharmacological treatment; 85% were referred to dietitians.

Journal Article by Smit C, Janssen-Heijnen ML (…) Konsten JLM et 2 al. in Tech Coloproctol

© 2025. The Author(s).

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Postoperative Pulmonary Risks in Emergency Laparotomy

Postoperative pulmonary complications are a major threat in emergency laparotomy, significantly impacting patient survival.

  • Pulmonary complications occur in 20-40% of patients and are linked to a mortality rate of 42.1% versus 11.9% for those without.
  • Key predictors for these complications include ASA score and gram-negative multi-drug resistant organism colonization.

Taking action on antibiotic therapy for high-risk patients could help reduce these life-threatening complications.

  • Targeting these predictors may reshape perioperative guidelines for more vulnerable emergency cases.

Journal Article by Amati AL, Negruta N (…) Hecker A et 6 al. in Front Med (Lausanne)

Copyright © 2025 Amati, Negruta, Ebert, Kümmel, Fritzenwanker, Wolff, Petzoldt, Reichert and Hecker.

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New CRP Guidelines for Predicting Anastomotic Leakage in Colorectal Surgery

Elevated C-reactive protein (CRP) levels post-surgery are key in predicting anastomotic leakage, improving decision-making for surgeons.

  • On postoperative day 3, CRP had an AUC of 0.91 with a cutoff of 18.69 mg/l for predicting leakage.
  • On day 5, the AUC improved to 0.93 with a cutoff of 14.25 mg/l.

This predictive tool can enable timely interventions, enhancing patient outcomes.

  • Both measurements showed high sensitivity and specificity for anastomotic leakage prediction.

Journal Article by Zayas-Bórquez R, Canto-Losa J (…) Santes O et 2 al. in Rev Gastroenterol Mex (Engl Ed)

Copyright © 2025 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.

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