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Nomogram Combined Treatment Data is More Effective than AJCC Staging System for Predicting Overall Survival in GEP-NETs

Researchers conducted a study to develop and validate a nomogram for predicting overall survival (OS) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Using data from the SEER registry, they identified key prognostic factors and compared the nomogram’s performance to the AJCC staging system. The results showed that the nomogram, which combined treatment data, had a higher concordance index and lower AIC values, indicating better discrimination in predicting OS. The nomogram is recommended for evaluating individual risks and improving diagnosis and treatment outcomes for GEP-NETs patients.

Journal Article by Wu Z, Shang G (…) Lin R et 3 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Study Finds Over Half of ESG Patients Require Opioids in the Perioperative Setting

A retrospective study on endoscopic sleeve gastroplasty (ESG) evaluated the need for peri- and postoperative opioid therapy. Of the 67 patients included, 58.2% required opioids in the perioperative setting, with a mean dose of 12.3 mg morphine milligram equivalents (MMEs). Furthermore, 17.9% of patients required home opioid prescriptions postoperatively, while more than a third reported no pain. The study emphasizes the importance of individualizing opioid therapy to minimize overprescription and the risk of opioid overuse in ESG patients.

Journal Article by Moy BM, Volk S (…) Schulman AR et 2 al. in Am J Gastroenterol

Copyright © 2024 by The American College of Gastroenterology.

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Surgeon Well-Being Impacted by Home Call: Loss of Sleep and Burnout Results

Home call for acute care surgeons was found to have detrimental effects on sleep and burnout, even without receiving calls or returning to the hospital. A study involving 224 surgeons wearing tracking devices and completing daily surveys revealed that home call without calls resulted in 3 minutes of sleep loss, while home call with calls led to an additional 14 minutes of sleep loss, and home call with a return to the hospital caused a further 70 minutes of sleep loss. These variations of home call also reduced feelings of restedness and increased daily burnout, emphasizing the need for careful consideration of call schedules to mitigate adverse effects on health and well-being.

Journal Article by Coleman JJ, Robinson CK (…) Cohen MJ et 3 al. in J Am Coll Surg

Copyright © 2024 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Three-Dimensional-Guided Laparoscopic Radical Resection for Left Perihilar Cholangiocarcinoma: Improved Precision and Efficiency

Utilizing three-dimensional reconstruction, clinicians performed a successful laparoscopic left hepatectomy and caudate lobectomy in a patient with left perihilar cholangiocarcinoma. The reconstruction revealed tumor invasion into the left hepatic artery and left portal vein. The procedure lasted 425 minutes with minimal blood loss. The patient’s postoperative recovery was smooth, and no recurrence was observed at the 6-month follow-up. This study suggests that 3D reconstruction-guided laparoscopic radical resection can enhance precision and efficiency in selected perihilar cholangiocarcinoma cases, potentially yielding outcomes comparable to open surgery.

Journal Article by Ma WJ, Yang C, Jin YW and Li FY in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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Pancreatectomy Induces Cancer-Promoting Neutrophil Extracellular Traps: Implications for Perioperative Management

Post-pancreatectomy, patients exhibit elevated cancer-promoting neutrophil extracellular traps (NETs), peaking on days 3 and 4, linked to changes in neutrophil biology. NET-inducing cytokines (IL-8, IL-6, G-CSF) increase postoperatively, with the robotic approach potentially reducing NETs compared to open surgery. Patients with pancreatic leaks show increased NET markers. The study suggests pancreatectomy induces cancer-promoting NET formation, with implications for minimizing NETs during the perioperative period.

Journal Article by Ivey AD, Pratt HG (…) Boone BA et 7 al. in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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No Reduction in Surgical Site Infection with Dual Antibiotic Irrigation in Ventral Hernia Repair: RINSE Trial Findings

In a randomized trial for ventral hernia repair, dual antibiotic irrigation (gentamicin + clindamycin) did not significantly reduce surgical site infection (SSI) rates compared to saline irrigation. No differences were observed in secondary outcomes, suggesting that this antibiotic approach may not offer additional benefits in preventing SSIs in this context.

Journal Article by Warren JA, Lucas C (…) Carbonell AM et 12 al. in Am J Surg

Copyright © 2024 Elsevier Inc. All rights reserved.

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Insufficient Evidence for the Beneficial Effects of Vitamin D Supplementation on Surgical Outcomes

After systematically reviewing 14 randomized controlled trials involving 1982 surgical patients, researchers found insufficient evidence to support the use of vitamin D supplementation in improving overall survival or postoperative mortality rates. The studies varied in patient conditions, surgical procedures, and dosages of vitamin D administered. Furthermore, there was no clear evidence suggesting any benefits in terms of overall length of stay or intensive care unit stays. These findings challenge the notion of a single biological effect of vitamin D supplementation in surgical settings.

Journal Article by Patel A, Caruana EJ (…) Lim E et 16 al. in BMJ Open

© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Beppu score helps stratify recurrence risk and guide selection of perioperative chemotherapy for colorectal liver metastases

Recurrence-risk stratification using the Beppu score can help clinicians estimate the postoperative disease-free survival for colorectal liver metastases. The study identified three risk groups based on the Beppu score: low, moderate, and high-risk. For each group, different treatment options were recommended: hepatectomy alone for low-risk, hepatectomy with adjuvant chemotherapy for moderate-risk, and hepatectomy with preoperative chemotherapy for high-risk patients. The Beppu score can assist in determining the need and timing of perioperative chemotherapy.

Review by Beppu T, Yamamura K (…) Miyamoto Y et 2 al. in J Surg Oncol

© 2024 Wiley Periodicals LLC.

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Body Mass Index Does Not Predict Injury Pattern or Outcome After Motorcycle Crash

The study aimed to compare the injury severity, mortality, injury regions, and length of hospital and intensive care unit stay between obese and normal-weight motorcycle crash patients. The analysis of trauma registries from three Pennsylvania level 1 trauma centers on 1,164 adult motorcycle crash patients showed no significant difference in injury severity, mortality, or injury distribution between obese and normal-weight patients. The study challenges existing data suggesting that obese motorcycle drivers may have different injury characteristics and increased length of stay.

Journal Article by Allsbrook A, To JQ (…) Braverman MA et 7 al. in J Surg Res

Copyright © 2023 Elsevier Inc. All rights reserved.

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Harmonizing Data Dictionaries in Colorectal Cancer Registries

Researchers conducted a mapping exercise to identify opportunities for data dictionary harmonization in colorectal cancer outcome registries. They compared data dictionaries from three major registries and developed a combined comprehensive dataset of 225 fields under seven domains. A common dataset with 38 overlapping fields was also created. The study highlighted areas of commonality and difference across registries and provided a foundation for benchmarking and harmonization of data dictionaries. The findings have the potential to facilitate meaningful international outcomes research.

Journal Article by Mohan HM, Sijmons JML (…) Smart P et 10 al. in Eur J Surg Oncol

© 2023 Published by Elsevier Ltd.

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