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Gastrectomy Reduces Long-Term Cardiovascular Risks for Gastric Cancer Survivors

Gastrectomy significantly lowers the risk of cardiovascular diseases and obesity-related cancers compared to endoscopic resection in gastric cancer survivors. An analysis of 74,367 matched patients revealed that those who underwent gastrectomy experienced fewer major adverse cardiovascular events, lower incidences of conditions like hypertension and ischemic heart disease, and decreased death rates from obesity-related cancers. However, they face a heightened risk of respiratory disease mortality. Annual medical costs for diabetes and hypertension were also lower in these patients.

Journal Article by Woo HT, Kang SH (…) Suh YS et 7 al. in J Am Coll Surg

Copyright © 2025 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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HAIP chemotherapy significantly enhances survival in liver cancer patients

Hepatic arterial infusion pump (HAIP) chemotherapy delivers targeted therapy directly to the liver, markedly improving survival outcomes in liver-confined colorectal metastases (CRLM) and intrahepatic cholangiocarcinoma (ICCA). In unresectable CRLM, five-year overall survival rates reach 50%. Adjuvant HAIP after tumor resection shows two-year survival of 86%, compared to 72% with systemic therapy alone. ICCA patients benefit similarly, with response rates up to 58% and three-year overall survival as high as 43%.

Review by Outmani L, Rousian M (…) Gholami S et 5 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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65% of Patients Return to Normal Activities Within 30 Days Post-Surgery

Within 30 days of major abdominal surgery in low- and middle-income countries (LMICs), 65.3% of patients reported returning to normal activities. Factors influencing recovery included the type of surgery: patients undergoing benign procedures (67%) and minor operations (71%) experienced higher return rates than those with cancer or major surgeries. The urgency for rehabilitation pathways is amplified by the increasing global surgical care demands, highlighting the need to enhance recovery for these populations.

Journal Article by Omar O and Kamarajah SK in BMC Surg

© 2025. The Author(s).

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Adjuvant therapy significantly improves survival after distal cholangiocarcinoma surgery

Adjuvant therapy markedly enhances overall survival (OS) and disease-free survival (DFS) in patients post-pancreaticoduodenectomy for distal cholangiocarcinoma. A meta-analysis of 22 studies involving 7,078 patients revealed an OS hazard ratio of 0.80 and a DFS hazard ratio of 0.84 for adjuvant therapy compared to follow-up alone. Notably, combined chemo-radiotherapy yielded the best outcomes, though high heterogeneity in study results warrants caution in interpretation.

Journal Article by Nappo G, D’Ambra V (…) Zerbi A et 7 al. in Updates Surg

© 2025. The Author(s).

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Zero Post-Procedure Bleeding Achieved with New Closure Technique After Colon Resection

A prospective study of 1,133 patients undergoing colorectal endoscopic mucosal resection (EMR) using the Perfect Closure (PC) technique reported zero instances of delayed bleeding. This innovative method involved secure clipping without gaps and avoided clip-on-clip placements. The average number of clips used was 4.71 per lesion, with an average tumor diameter of 8.0 mm. Monte Carlo simulations suggested both medical and economic benefits over traditional closure methods, indicating significant progress in minimizing complications.

Journal Article by Homma K, Nawa S (…) Homma N et 4 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Metabolic Surgery Significantly Improves Liver Health in MASH Patients

Metabolic bariatric surgery markedly enhances glycemic control and liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH). A scoping review of 14 studies reveals substantial reductions in fasting glucose, insulin resistance, and liver enzymes, alongside histological improvements, including decreased steatosis and fibrosis. These changes, observed over follow-up periods of 6 months to 5 years, underline the procedure’s potential as a key treatment strategy for addressing MASH effectively and improving metabolic health.

Review by Shah A, Mohammadi A (…) Zevin B et 2 al. in Obes Surg

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Prior Gastrointestinal Infections Dramatically Increase Risk of Post-ERCP Infections

Patients with prior gastrointestinal infections face a significantly elevated risk of post-endoscopic retrograde cholangiopancreatography (ERCP) biliary tract infections (PEBTI). In a cohort study of 1,507 individuals, the incidence was 5.4% among those with prior infections versus 4.2% without. After adjusting for confounders, the hazard ratio rose sharply to 2.71, underscoring the need for enhanced prophylactic measures tailored to this vulnerable group. Robust findings emphasize the importance of addressing preoperative gastrointestinal colonization.

Journal Article by Chen Y, Liu J (…) Li P et 8 al. in J Gastroenterol Hepatol

© 2025 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

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Comorbidities and Age Elevate Non-Operative Management Failure in Adhesive Bowel Obstruction

In a substantial analysis of over 1.6 million adhesive small bowel obstruction cases, failure rates for non-operative management soared with increasing age and chronic health issues. Patients over 65 and those with multiple comorbidities faced notably higher risks, with failure rates climbing from 21% in the absence of comorbidities to 26.5% in affected individuals. Surgical intervention was also more common in older patients, underscoring the need for targeted management strategies for this vulnerable population.

Journal Article by Malkiely G, Paran M, Elgabsi M and Kessel B in J Clin Med

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Circulating Tumor DNA Testing Aligns with Tissue Analysis in Pancreatic Cancers

A study of 790 patients with advanced pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CC) reveals strong mutation concordance (MCR) between circulating tumor DNA (ctDNA) and tissue next-generation sequencing (NGS). In PDAC, 65.4% showed shared alterations, while CC had 66.7%. Additionally, ctDNA could signal resistant clones: increased TP53 variant frequencies correlated with a greater likelihood of disease progression (OR 7.28). This positions ctDNA as a critical tool for diagnosis and monitoring.

Journal Article by Mahadevia H, Majeed U (…) Babiker H et 21 al. in JAMA Netw Open

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New Nomograms Predict Surgical Risks in High-Risk GI Cancer Patients

A novel predictive model offers cancer-specific risk stratification for patients undergoing high-risk upper gastrointestinal surgeries. Analyzing 2,823 patients at Memorial Sloan Kettering, the study identifies key risk factors like age and comorbidities that elevate postoperative complications and length of stay. Notably, neoadjuvant chemotherapy and pre-incision antibiotics were linked to reduced hospital stays. The developed nomograms, with a c-index of 0.66 for complications, empower clinicians with essential tools for patient risk assessment and treatment planning.

Journal Article by Abate M, Lin ST (…) Strong VE et 12 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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