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Upper Gastrointestinal Tract ·

Salvage Surgery After Proton Beam Chemoradiotherapy for Esophageal Cancer

Salvage surgery for esophageal squamous cell carcinoma after proton beam chemoradiotherapy shows significant morbidity but no operative mortality, indicating careful patient selection is crucial.

  • In a study of 19 patients, major morbidity was reported in 47.3% post-salvage surgery, with a median overall survival of 16.2 months.
  • The 1-, 3-, and 5-year overall survival rates were 68.0%, 43.1%, and 35.9%, respectively.

Surgeons should weigh the high risk of complications against potential survival benefits when considering salvage surgery in these patients.

Journal Article by Kakinuma H, Honda M (…) Takano Y et 5 al. in Ann Surg Oncol

© 2026. Society of Surgical Oncology.

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