The long-term results of a phase II trial evaluating neoadjuvant gemcitabine, nab-paclitaxel, and S1 treatment in borderline resectable pancreatic cancer with arterial contact (BRPC-A) show promising outcomes. Of the 47 patients, 96% underwent pancreatectomy, and the updated median overall survival was 41.0 months with 2- and 5-year survival rates of 68.0% and 44.6%, respectively. Tumor […]
Author: STITCHES Newsletter
Recurrence Risk in Ampullary Adenomas: FAP vs. Sporadic Cases After Endoscopic Papillectomy
Recurrence rates of ampullary adenomas (AA) after endoscopic papillectomy (EP) were compared between patients with familial adenomatous polyposis (FAP) and sporadic AA. The study included 257 patients from 10 tertiary hospitals. Recurrence occurred in 48% of patients with FAP and 36.9% of patients with sporadic AA. The risk of recurrence was higher in FAP patients […]
Impact of Intraoperative Neural Monitoring on Thyroidectomy Completeness and Thyroglobulin Response in Papillary Thyroid Cancer Patients
In a study evaluating the effect of intraoperative neural monitoring (IONM) during papillary thyroid cancer surgery, researchers found that IONM significantly improved the completeness of thyroidectomy and reduced postoperative levels of stimulated thyroglobulin. Patients who underwent IONM had lower thyroglobulin levels and a higher percentage of patients with levels below 1ng/ml. This information can help […]
Disparities in Emergency General Surgical Procedures for HIV and HCV Patients in the US
People living with HIV (PLWHIV) and people living with hepatitis C virus (PLWHCV) are less likely to receive emergency general surgical procedures (EGS) than similar patients without these conditions. This is the main result of a study analyzing data from over 500,000 non-elective admissions in the United States between 2016 and 2019. Specifically, PLWHIV had […]
Robotic limited liver resections show superior perioperative outcomes compared to laparoscopic limited liver resections for posterosuperior segments
Robotic limited liver resections (RLLR) resulted in superior perioperative outcomes compared to laparoscopic limited liver resections (LLLR) for posterosuperior liver segments, including reduced open conversion rate, blood loss, and operative time. These benefits were observed in both the overall population and in patients with cirrhosis. Postoperative outcomes regarding readmission, morbidity, and mortality were similar between […]
Neoadjuvant Chemotherapy Improves Survival in Resectable Pancreatic Adenocarcinoma Patients
Multiagent neoadjuvant chemotherapy (NAC) followed by surgery is associated with improved overall survival compared to upfront surgery or single-agent NAC in patients with resectable pancreatic adenocarcinoma. A nationwide study conducted on 5,216 patients found that multiagent NAC led to longer median overall survival (35.8 months) compared to upfront surgery (27.1 months) and single-agent NAC (27.4 […]
Procedure-specific Risks of Thrombosis and Bleeding in Abdominal Surgery Vary Significantly
This systematic review and meta-analysis of 285 studies, including over 8 million patients, evaluated the procedure-specific risks of symptomatic venous thromboembolism (VTE) and major bleeding in general abdominal, colorectal, upper gastrointestinal, and hepatopancreatobiliary surgeries. The risk of VTE varied widely among procedures, with VTE rates ranging from
Prognostic Relevance of Primary Tumor Sidedness in Early-stage Colorectal Cancer
The study analyzed data from four randomized controlled trials to determine the significance of primary tumor sidedness (PTS) in early-stage colorectal cancer. The results showed that PTS had no impact on the risk of recurrence in stage II/III colorectal cancer. Treatment stratification based on PTS is unnecessary for early-stage colorectal cancer. However, PTS was significantly […]
Impact of Omitting Additional Surgery on Prognosis in Patients with High-Risk T1 Colorectal Cancer
For patients with high-risk T1 colorectal cancer, the need for additional surgery after local excision (LE) is uncertain. A study analyzed patients who had received LE between 2009 and 2016. Comparing those who received additional surgery and those who did not, researchers found that regional lymph node metastasis occurred in 7.7% of the surgery group. […]
Metabolic surgery effectively resolves nonalcoholic steatohepatitis and improves fibrosis in patients with obesity
Metabolic surgery has been found to facilitate the resolution of nonalcoholic steatohepatitis (NASH) and improve fibrosis in patients with obesity. A study comparing the histologic outcomes of metabolic surgery versus nonsurgical care in individuals with fibrotic NASH revealed that half of the surgical patients achieved simultaneous resolution of NASH and improvement in fibrosis, compared to […]