The study showed that simultaneous resection of liver metastases combined with HIPEC resulted in a significantly higher complete resection rate, total effective rate, and negative change of CEA compared to resection alone. This approach demonstrated superior efficacy in treating synchronous colorectal cancer liver metastases, potentially extending patient survival and improving quality of life. Journal Article […]
Category: Cytoreductive Surgery & Peritoneum
Centralization of Cytoreductive Surgery Alone Improves Perioperative Outcomes for Colorectal Peritoneal Metastases
Centralization of cytoreductive surgery alone for colorectal peritoneal metastases improved 90-day postoperative mortality and failure-to-rescue rates. High-volume centers showed lower mortality rates compared to low-volume and no-hipec centers. After the Prodige 7 trial, there was a drastic decrease in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy rates in cancer centers, while patients treated with cytoreductive surgery […]
Histological Growth Pattern Predicts Survival in Peritoneal Metastases
Patients with colorectal peritoneal metastases who underwent cytoreductive surgery had better disease-free and overall survival if they had a dominant pushing histological growth pattern compared to infiltrating pattern. The study confirmed the prognostic value of these patterns regardless of neoadjuvant chemotherapy or extent of peritoneal disease burden. No significant associations were found between neoadjuvant chemotherapy […]
Improved Pain Management and Recovery After Implementation of ERAS Protocol for CRS-HIPEC
Enhanced Recovery After Surgery (ERAS) protocol implementation for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) led to increased epidural use, decreased oral and intravenous opioid requirements, and earlier restoration of bowel function. Patients with epidurals had significantly lower opioid needs post-ERAS, with improved ambulation, diet initiation, and return of bowel function compared to pre-ERAS patients. […]
Improved Odds of Cytoreductive Surgery with HIPEC and Survival for Colorectal Peritoneal Metastases
Findings from a nationwide population-based study revealed that patients diagnosed in hipec centers had better odds of undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) and improved survival rates before 2016. However, after national efforts to increase awareness and improve referral networks, these differences were no longer present between patients diagnosed in hipec and referring […]
Impact of Laparoscopic HIPEC on Safety and Perioperative Outcomes in Gastric Cancer with Peritoneal Metastasis
Laparoscopic HIPEC for gastric cancer with peritoneal metastasis is safe and associated with minimal perioperative complications. Approximately one third of patients undergoing initial laparoscopic HIPEC proceeded to cytoreduction and gastrectomy. Preliminary survival data from this study indicate a median overall survival of 11 months from the initial procedure and 19.3 months from the diagnosis, suggesting […]
Ki-67 Proliferation Index as a Potential Surrogate for Tumor Grade in Pleural Epithelioid Mesotheliomas
Ki-67 proliferation index was found to be associated with tumor grade in pleural epithelioid mesotheliomas, showing comparable predictability for overall survival to mitotic score. High Ki-67 index and mitoses were significantly linked to poor overall survival, suggesting that Ki-67 index by digital image analysis could serve as a reliable surrogate for tumor grade in assessing […]
High risk of venous thromboembolism in peritoneal mesothelioma patients highlights need for vigilant monitoring
Peritoneal mesothelioma patients had a high venous thromboembolism (VTE) risk, with 21.7% experiencing VTE, mainly symptomatic pulmonary emboli. 4-week thromboprophylaxis post-surgery resulted in acceptable 90-day VTE rates. Surgical patients and those with low serum albumin had higher VTE risk, but overall survival did not significantly differ between patients with and without VTE. These findings underscore […]
HIPEC in Appendiceal Adenocarcinoma After Perforated Appendicitis: Encouraging 5-Year Survival
Among patients diagnosed with appendiceal adenocarcinoma after acute perforated appendicitis, half may have peritoneal metastasis. Prophylactic cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in cases without identified metastasis during CRS may lead to an encouraging rate of disease-free survival at 5 years, with a recurrence rate of 12.5% and 100% overall survival. Surgical complications […]
CR/HIPEC Study Shows Decreased Opioid Use and Shortened Hospital Stay with Continuous Wound Irrigation and Intraoperative Methadone
Continuous wound irrigation and intraoperative methadone usage in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) significantly reduced opioid use and shortened length of hospital stay compared to epidural analgesia. The combination of continuous wound infusion system (CWIS) and methadone resulted in lower total and daily opioid exposure. The CWIS-only group had lower oral opioid exposure […]