The study compared endoscopic and surgical treatment in acute necrotizing pancreatitis, showing that endoscopic treatment resulted in lower peri-interventional morbidity, shorter hospital stays, and lower mortality rates. Endoscopic treatment also led to better long-term outcomes with reduced renal insufficiency, ventilation dependency, and recurrence rates, along with improved exocrine functionality. These findings suggest a preference for […]
Category: HPB & Spleen
Superior tumor response and survival with triple therapy regimen in hepatocellular carcinoma
Triple therapy regimen (ICI+TKI+TACE) showed higher disease control rate and overall survival compared to other treatments in patients with advanced hepatocellular carcinoma. It had a higher disease control rate than ICI+TACE, ICI+TKI, and TKI+TACE, as well as improved overall survival compared to ICI+TKI and TKI+TACE. However, it also had a greater incidence of adverse events. […]
Medicaid Expansion Increases Access for PDAC Patients in Southern States
Medicaid Expansion in southern states significantly increased insurance access for underserved groups with pancreatic ductal adenocarcinoma (PDAC). Expanded states had a 36% higher odds of Medicaid insurance and increased proportions of insured black, rural, and impoverished patients. However, the odds of receiving radiation therapy decreased annually in expanded states. Although ME did not impact the […]
Adjuvant Therapy Benefits Pancreatic Cancer Patients with Short Neoadjuvant Duration or Microscopic Margins
A retrospective study on 529 pancreatic cancer patients after neoadjuvant therapy reveals adjuvant therapy’s survival benefit. For the entire cohort, no significant overall survival difference was observed. However, subgroup analysis shows a survival advantage with adjuvant therapy for those with less than 4 months of neoadjuvant treatment or microscopic margin positive surgical resections. This insight […]
Long-term Mortality Risk in Total Pancreatectomy Patients with Islet Autotransplant
Total pancreatectomy with islet autotransplant (TPIAT) for pancreatitis patients has a 10-year survival rate of 85.2% and a 15-year rate of 76.2%. Most deaths (53 out of 89) were possibly related to TPIAT, with causes including chronic gastrointestinal issues, malnutrition, and diabetes. Younger age, longer disease duration, and recent procedures were linked to lower mortality. […]
Impact of KRAS and Histopathological Growth Patterns on Resection Margins in Colorectal Liver Metastases
In colorectal liver metastases (CRLM), the review investigates the association between KRAS status, histopathological growth patterns (HGPs), and their impact on resection margins around major vasculature and bile ducts. The study emphasizes the importance of balancing negative margins and preserving vascular and biliary structures during surgery. While parenchymal sparing is crucial, the review explores how […]
Advances in Targeted Therapy for Cholangiocarcinoma Patients
Research highlights the poor 5-year survival rates post-surgical resection for cholangiocarcinoma patients and the effectiveness of gemcitabine combined with platinum as first-line chemotherapy for advanced cases. Targeted therapy shows promise, but challenges include adverse reactions, drug resistance, and individual differences. The study emphasizes the need for further research to develop more effective and safe drugs, […]
Augmented Reality Improves Accuracy in Laparoscopic Liver Resection for Intraparenchymal Tumors
Augmented reality (AR) guidance significantly improves accuracy in laparoscopic liver resection for intraparenchymal tumors. The average pointing error for tumor localization was 29.4 mm for the laparoscope axis and 9.2 mm for the operator port axis, with errors increasing with tumor depth. While there was no significant dependency on tumor size, AR projection towards the […]
Crucial Prognostic Factors in Ampullary Cancer: Nodal Staging and Lymph Node Examination
Patients with ampullary cancer benefit from examination of a minimum of 20 lymph nodes to accurately predict prognosis and minimize stage migration. The log odds transformation nodal classification scheme showed the highest accuracy in differentiating survival outcomes. Additionally, nodal metastasis in regional lymph nodes is linked to poorer outcomes post-surgery. Journal Article by Resende V, […]
Implementation of Best Practices in Pancreatic Cancer Care: Limited Impact on Survival and Quality of Life
In a randomized trial involving 5,887 pancreatic cancer patients, implementing best practices, including optimal chemotherapy and supportive care, showed no improvement in one-year survival or quality of life. Notably, a substantial number of patients did not receive tumor-directed treatment, emphasizing the necessity for more personalized therapeutic approaches in pancreatic cancer care. Journal Article by Mackay […]