A Delphi consensus involving 45 experts from 17 countries reached recommendations on gallbladder cancer management, achieving consensus on 92.6% of 68 clinical questions. Key areas covered include definitions for radical resections, management strategies for early and advanced disease, and the categorization of borderline resectable cases. These guidelines promote uniform terminology and offer practical frameworks for […]

A novel nomogram was developed to predict clinical outcomes for gallbladder cancer patients post-surgery, incorporating inflammatory and nutritional biomarkers. It identified carcinoembryonic antigen, albumin-bilirubin, and geriatric nutritional risk index as key prognostic factors. With a c-index of 0.793, the nomogram demonstrated superior predictive ability compared to existing models, achieving area under the curve values of […]

Assessment of drain fluid amylase levels on days one and three provides a reliable estimate of the risk for clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatoduodenectomy. A study of 923 patients showed that integrating both dfa1 and dfa3 into a predictive model yielded a cross-validated area under the curve of 0.846, enabling the development […]

Utilization of near-infrared fluorescence imaging during laparoscopic hepatectomy significantly improved tumor identification and secured clear resection margins in colorectal liver metastasis. Of the 94 tumors, fluorescence imaging detected 56 (59.6%), resulting in a 96.6% clear margin success rate for the 59 patients studied. Pathological assessment found no tumor cells associated with fluorescence, showcasing the method’s […]

A simple predictive model for early recurrence of hepatocellular carcinoma (HCC) post-liver resection has been developed. Based on an analysis of 1,133 patients, five key prognostic factors—alpha-fetoprotein levels and AJCC stage—were identified. Among the cohort, 35.1% experienced early recurrence within two years, with respective two-year recurrence-free survival rates of 79%, 57%, and 35% for low, […]

In a systematic review of 738 pancreatic head cancer patients, total mesopancreas excision (TMPE) significantly increased R0 resection rates (RR 1.24) and reduced overall (RR 0.53) and local recurrence rates (RR 0.39) compared to standard pancreatoduodenectomy. TMPE also reduced blood loss (MD -143.70 ml) and enhanced lymph node harvest (MD 7.27 nodes), all while showing […]

Camrelizumab plus apatinib in a real-world setting has shown significant benefits in recurrence-free survival (RFS) for patients with hepatocellular carcinoma (HCC) with microvascular invasion following radical resection. The comparison between adjuvant therapy (99 patients) and observation (172 patients) indicated a hazard ratio of 0.52 for RFS improvement (p

A computer vision algorithm was developed to predict superior mesenteric artery (SMA) margin status in pancreatic ductal adenocarcinoma patients using preoperative CT scans. In a study involving 200 patients, the algorithm achieved a sensitivity of 0.43, outperforming radiologists (0.23) and surgeons (0.36). Specificity was high across the board, with both the algorithm and a radiologist […]

The study established tumor fibrosis as an independent prognostic factor for survival in pancreatic ductal adenocarcinoma (PDAC) patients, identifying a 40% collagen fraction cut-off value crucial for prognosis differentiation. Utilizing a CT-based radiomics model, researchers achieved areas under the curve of 0.825 and 0.745 in training and test cohorts, respectively, outperforming traditional models in predicting […]