Results of an international survey show substantial variability in European hpb surgery fellowship programs, highlighting the need for a more standardized clinical curriculum. Fellowships typically last one or two years, with funding provided in 70% of cases. Fellows commonly perform pancreatic and liver resections as first surgeons, while minimally invasive procedures make up less than […]
Category: HPB & Spleen
Comparing Simple and Radical Cholecystectomy in T1B Gallbladder Cancer: Similar Survival Outcomes
Among 950 patients with pathologic T1B gallbladder cancer, receiving either simple or radical cholecystectomy, there was no significant difference in median overall survival between the two groups. This suggests that highly selected patients may not benefit from extended resection, highlighting comparable outcomes with simple cholecystectomy in this population. Journal Article by Rhodin KE, Goins S […]
Liver Resection Outperforms Ablation in Multifocal Hepatocellular Carcinoma
Examining T2 multifocal hepatocellular carcinoma (MHCC), researchers compared liver resection (LR) and tumor ablation (TA) in a cohort of 1225 patients. Despite higher 30-day mortality with LR, 10-year overall survival favored LR over TA (27.5% vs. 14.7%). Stratified analysis revealed significant benefits in patients with negative resection margins, no lymphovascular invasion, and a Charlson-Deyo score […]
Postoperative Adjuvant Chemotherapy Improves Overall Survival in Colorectal Cancer Liver Metastases Patients
A retrospective study investigated the impact of postoperative adjuvant chemotherapy (POAC) on outcomes in patients with colorectal cancer liver metastases (CRLM) undergoing simultaneous resection. After propensity score matching analysis, 478 patients were enrolled and assigned to POAC or non-POAC groups. The study found that POAC significantly improved overall survival (OS) but not progression-free survival (PFS) […]
Cell neighborhoods in pancreatic ductal adenocarcinoma impact clinical outcomes
Cell neighborhoods within the tumor microenvironment of pancreatic ductal adenocarcinoma (PDA) play a crucial role in determining clinical outcomes. Researchers used immunohistochemistry and image analysis to study cell neighborhoods in PDA tumors from chemotherapy-naïve and chemotherapy-treated patients. They found that distinct intratumoral immune and tumor cell subsets were defined by neighboring cells. Chemotherapy-treated tumors had […]
Prognosis-Oriented Definition of Borderline Resectable Hepatocellular Carcinoma for Improved Patient Outcomes
Researchers proposed a prognosis-oriented definition for borderline resectable hepatocellular carcinoma (HCC) based on a study of 221 patients. They identified risk factors for early recurrence, including serum α-fetoprotein levels ≥12 ng/ml, tumor diameters >5 cm, tumor number ≥3, and macrovascular invasion. With these criteria, they defined borderline resectable HCC as a tumor with two or […]
Significant Outcomes of Establishing a Hepato-Pancreato-Biliary Surgery Service in Uganda
Researchers analyzed data from patients who underwent complex hepato-pancreato-biliary surgeries in Uganda, reporting that most patients were females with a median age of 50 years. The most common surgeries performed were on the bile ducts, with a high prevalence of malignancy. Despite challenges like limited access to imaging technology, the in-hospital mortality rate was relatively […]
A Novel Serum Exosomal miRNA Signature Predicts Persistent Organ Failure in Acute Pancreatitis
This study aimed to identify potential biomarkers for early prediction of persistent organ failure (POF) in acute pancreatitis (AP) patients. Using serum exosomal miRNAs, researchers identified a classifier comprising three miRNAs (miR-4265, 1208, 3127-5p) that demonstrated high predictive value for POF. This classifier outperformed other clinical indicators and was effective in identifying prediagnostic POF in […]
Study Finds Adverse Events Associated with Single Operator Cholangioscopy System
Analysis of the MAUDE database reveals that the single operator cholangioscopy (SOC) system, specifically the SpyGlass DS and DS II devices, carries additional risks compared to standard endoscopic retrograde cholangiopancreatography. The study identifies 2,331 device problems reported between January 2016 and August 2023, with optical issues being the most prevalent. Patient-related events were found in […]
Salvage Surgery Improves Overall Survival Rates in Unresectable Hepatocellular Carcinoma Patients
Among patients with initially unresectable hepatocellular carcinoma (uhcc), combination therapy with transcatheter arterial chemoembolization, lenvatinib, and anti-PD-1 antibodies achieved high tumor response rates and converted some cases to resectable disease. A retrospective study compared outcomes in uhcc patients who underwent salvage surgery (sr group) versus those who did not (non-sr group). The sr group demonstrated […]