In a meta-analysis involving 588 patients, liver venous deprivation (LVD) improved liver resection rates (OR, 1.89), accelerated liver growth rates, and shortened time to surgery compared to portal vein embolization (PVE). Notably, LVD resulted in lower post-hepatectomy liver failure (OR, 0.45) without increasing complications or mortality rates. Thus, LVD not only proves effective for liver […]

An imaging-derived biomarker effectively stratified mvi-positive HCC patients for adjuvant hepatic arterial infusion chemotherapy (HAIC). In a study of 470 patients, key imaging features distinguished prognostic subgroups, leading to significantly different recurrence-free survival rates (RFS) (median RFS, 6.00 vs. 66.00 months, p

A preoperative risk model developed by clinicians identified criteria to predict futile up-front pancreatectomy in patients with anatomically resectable pancreatic cancer. Among 1,426 patients, the rate of futile pancreatectomy was 18.9%. Clinicians identified four specific tumor size and cancer antigen (CA 19.9) criteria that maintained futility likelihood below 20%. Patients meeting these criteria demonstrated significantly […]

Findings reveal the albumin-lymphocyte-globulin-C-reactive protein (ALGC) index as a significant prognostic biomarker for hepatocellular carcinoma (HCC) after hepatectomy. In a cohort of 178 patients, a low ALGC index (

A systematic review covering 3,610 patients undergoing distal pancreatectomy reveals that a no-drainage approach significantly reduces complications. The odds of postoperative pancreatic fistula decreased to 0.38, while major morbidity, readmissions, and reinterventions also showed considerable reduction (odds ratios of 0.64, 0.69, and 0.70, respectively). Additionally, patients experienced a shorter hospital stay by an average of […]

A cohort study identified specific bile microRNAs (miRNAs) that differentiate malignant from benign pancreaticobiliary diseases. Among 111 patients, 14 differentially-expressed miRNAs were identified, with bile miR-340 and miR-182 significantly validated. The study achieved an area under the curve (AUC) of 0.79, demonstrating sensitivity of 65% and specificity of 82% in predicting malignancy. These findings underscore […]

Development of a biodegradable prosthesis utilizing electrospun poly(d,l-lactide-co-glycolide)-polycaprolactone-gelatin nanofibers successfully demonstrated mechanical strength, biocompatibility, and biodegradability in a pig model. This innovative scaffold maintained bile duct permeability and facilitated cell adhesion and growth without adversely affecting liver function over two years. Notably, immunohistochemical evaluations confirmed the presence of biliary epithelium, showcasing the scaffold’s potential for […]

The ISGPS developed a complexity and experience grading system for minimally-invasive pancreatoduodenectomy (MIPD), aimed at enhancing patient selection. This system categorizes patient risk factors and surgeon experience, enabling optimal decision-making for safe MIPD implementation. It assesses anatomical and conditional risks alongside surgeon experience and center volume. By employing this evidence-based approach, the grading system facilitates […]

A new lasso-logistic regression model was developed and validated, identifying nine independent risk factors for postpancreatectomy hemorrhage among 9,631 patients across two cohorts. The model demonstrated strong predictive accuracy, achieving an area under the receiver operating characteristic curve of 0.87 during external validation, significantly outperforming previous prediction models (p