A retrospective cohort study investigated the use of serum carcinoembryonic antigen (CEA) as an alternative prognostic marker for overall survival in patients with localized pancreatic adenocarcinoma and non-elevated levels of carbohydrate antigen 19-9 (CA19-9). The study found that elevated CEA at baseline was independently associated with worse overall survival, and CEA normalization following preoperative therapy […]
Category: HPB & Spleen
Impaired liver function after major hepatectomy affects feasibility of adjuvant chemotherapy for biliary tract cancers
The study explored the feasibility of S-1 adjuvant chemotherapy after major hepatectomy for biliary tract cancers. Comparing major hepatectomy (mh) with non-major hepatectomy (nmh), researchers found that mh had a lower treatment completion proportion and dose intensity. Additionally, caution should be exercised to prevent biliary tract infections and gastrointestinal disorders during adjuvant S-1 chemotherapy after […]
Preoperative prediction model identifies risk factors for gallbladder adenoma
Researchers conducted a retrospective analysis to identify risk factors for gallbladder adenoma, a precancerous lesion. They analyzed data from patients who underwent cholecystectomy and found that age, gallbladder wall thickness, polyp size, echogenicity, pedunculation, and adenosine deaminase (ada) levels were independent predictors of gallbladder adenoma. Using these factors, they developed a preoperative prediction model with […]
Comparative Study Shows Comparable FLR Growth with RPVL and RPVE for Bilobar Liver Metastases
The results of a comparative study using a propensity score between right portal vein ligation (RPVL) and embolization (RPVE) for bilobar liver metastases from colorectal cancer show that RPVL and RPVE are both effective in providing left hemi-liver hypertrophy before right hepatectomy. There was no significant difference in future liver remnant (FLR) growth between the […]
Rectal Indomethacin Reduces Post-Operative Hyperamylasemia in Pancreatoduodenectomy
A randomized controlled trial assessed the efficacy of rectal indomethacin in preventing post-operative hyperamylasemia (POH) following pancreatoduodenectomy (PD). The study included 44 patients who either received 100mg of indomethacin per-rectally or standard care. The intervention arm had a significantly lower incidence of POH (28.6% vs. 60.9%) and reduced severity of delayed gastric emptying (DGE) compared […]
Somatic symptom severity and depression are more prevalent in surgical inpatients with pancreatitis
This study aimed to assess the prevalence of somatic symptom severity (sss), depression, and anxiety in surgical inpatients with different diagnostic groups of abdominal pain. The results showed that somatic symptoms were common, with 52% having moderate and 19.6% having severe sss. There was a significant association between moderate sss and pancreatitis, and between depressive […]
Ultra-Low-Pass Whole-Genome Sequencing of Circulating Tumor DNA Identifies Prognostic Markers in Hepatocellular Carcinoma
Ultra-low-pass whole-genome sequencing (ULP-WGS) of circulating tumor DNA (ctDNA) can provide clinically relevant information about tumor biology in patients with hepatocellular carcinoma (HCC) under systemic treatment. The presence of ctDNA and the loss of specific genomic regions (5q and 16q) were identified as independent predictors of worse prognosis in advanced HCC patients receiving systemic therapy. […]
Advances in the management of pancreatic cancer: A review of recent treatment strategies and future pathways
With a higher mortality rate compared to other cancers, pancreatic cancer poses significant challenges. However, there have been improvements in survival rates, although at a slower pace. Researchers have investigated multimodal treatment approaches involving chemotherapy, surgery, and radiotherapy. Recent advancements in treatment regimens show promise in developing new strategies. This review provides an overview of […]
Endoscopic Ultrasound Identifies Malignant Lymph Nodes in LT Work-up for Unresectable Perihilar Cholangiocarcinoma
The study investigated the impact of endoscopic ultrasound (EUS) in the liver transplantation (LT) work-up for patients with unresectable perihilar cholangiocarcinoma (PCCA). EUS screenings were performed on a selected group of patients, and the primary outcome was the number of patients precluded from further screening due to malignant lymph nodes (LN). The study found that […]
Precision Surgery Shows Promising Results for Colorectal Liver Metastases Patients with Mutras Tumors
The systematic review and meta-analysis of studies investigating the association of surgical technique with outcomes for colorectal liver metastases (crlm) found that anatomic resection (AR) was associated with improved liver-specific disease-free survival (DFS) and overall DFS in patients with mutras tumors. Specifically, AR resulted in a 40% improvement in liver-specific DFS and a 28% improvement […]