Whipple over the splenic artery (WOTSA) can replace most total pancreatectomies for ductal adenocarcinoma, offering similar complication rates but improved postoperative glycemic status and potentially better disease-free survival. Results show no reoperations required in the WOTSA group due to pancreas or spleen issues, with comparable operative outcomes to total pancreatectomy. Findings suggest WOTSA as a […]

Study finds higher relative dose intensity (RDI) of adjuvant S-1 chemotherapy and greater psoas muscle mass volume (PMV) linked to significantly improved 5-year overall and relapse-free survival rates in patients with resected pancreatic ductal adenocarcinoma. RDI emerges as an independent prognostic factor, with patients displaying high RDI and high PMV showing the best outcomes. Combining […]

Robotic surgery in hepato-pancreatic-biliary procedures is feasible and valuable for minimally invasive indications. Expertise is crucial for safety, encompassing requirements for credentialing in robotics. Prioritized questions for future trials include prospective registries with validated outcome metrics. The consensus guidelines from the Robot4HPB conference highlight state-of-the-art expertise and encourage safe use and promotion of robotic procedures […]

An atlas of hepatocellular carcinoma revealed seven genetic evolutionary paths influencing patient clinical trajectories. Most notably, the ‘bad apple’ effect showed that the aggressive cell fraction within tumors predicted prognosis better than overall heterogeneity levels, reshaping how clinicians predict survival. This study highlights the importance of tumor evolution in prognosis post-surgery and suggests personalized therapies […]

Barthel Index scores below 85 indicate higher risk for adverse surgical outcomes in elderly hepatocellular carcinoma patients undergoing hepatectomy. A retrospective cohort study of 497 patients found those with lower scores had significantly lower rates of achieving textbook outcomes (TO) post-surgery compared to higher score patients (29.3% vs. 72.1%). Assessment of functional decline using the […]

Laparoscopic and robotic distal pancreatectomy are more cost-effective than open surgery, with laparoscopic surgery showing better cost savings and robotic surgery having superior surgical outcomes and improved quality-adjusted life years. Both laparoscopic and robotic approaches resulted in significantly reduced hospitalization costs compared to open surgery, showcasing a more favorable profile in terms of costs-morbidity, costs-mortality, […]

Patients who undergo pancreatic resection face a 2.4-fold increase in pathological fractures, a 1.4-1.5 fold increase in osteoporosis/osteomalacia, and vitamin-D deficiency. Post-surgery, bone mineral density declines more rapidly compared to historical controls. Older age, pancreatic cancer, and specific surgical procedures contribute to higher rates of bone mineral density loss. Focus on prevention strategies is crucial […]

Postoperative antibiotic prophylaxis in pancreaticoduodenectomy bile duct stenting patients significantly reduced major complications such as reoperation and intensive care unit readmission. Targeted antibiotic treatment based on the biliary microbiome decreased the likelihood of developing wound infections. The study emphasizes the importance of appropriate antibiotic prophylaxis in reducing postoperative complications in this patient population. Journal Article […]

Comparative survival analysis of liver resection (LR), percutaneous radiofrequency ablation (PRFA), and transarterial chemoembolization (TACE) in early multinodular hepatocellular carcinoma (HCC) patients reveals LR as the preferred therapeutic option for improved survival rates at 1, 3, and 5 years. LR demonstrates superior outcomes compared to PRFA and TACE, highlighting the importance of considering LR as […]

Inside stent placement for preoperative biliary drainage in perihilar cholangiocarcinoma patients showed significantly lower rates of recurrent biliary obstruction, longer stent patency, fewer replacements, and reduced hospital stays and costs compared to conventional stent placement. Additionally, inside stent placement resulted in fewer complications and lower re-intervention rates, suggesting potential benefits for both patients and the […]