High intratumoural tertiary lymphoid structure (TLS) score correlated with prolonged survival, while high TLS density in adjacent tissue indicated worse prognosis in combined hepatocellular-cholangiocarcinoma. Mature TLSS linked to favorable outcomes with more CD8+ T cell infiltration. TLSS distribution and density can predict prognosis and serve as a potential immunotherapy biomarker. CXCL12 expression in tumor tissue […]

Novel HARO-ALPPS procedure significantly restricts hepatic artery blood supply post-surgery, enhancing liver regeneration in HCC patients with severe fibrosis. Results show superior outcomes in terms of mortality and liver function compared to conventional ALPPS procedure. Further studies required to confirm oncologic benefits of HARO-ALPPS in long-term follow-up. Journal Article by Wen Z, Jin Z (…) […]

3D imaging challenges traditional size-based classification of precancerous lesions in pancreatic ductal adenocarcinoma. Over 1400 lesions meeting size criteria for pancreatic intraepithelial neoplasia (PanIN) were identified in 3D analysis, with a quarter digitally sectioning as intraductal papillary mucinous neoplasms (IPMN). Half of these large lesions were visible on preoperative CT scans. Current classification based on […]

TRIANGLE operation, combined with adequate adjuvant chemotherapy, can improve the prognosis of pancreatic head cancer. The triangle operation is safe for PDAC patients undergoing PD, reduces local recurrence rates, and may enhance patient survival with proper adjuvant chemotherapy support, according to a retrospective study. This surgical approach shows promising long-term oncological outcomes for patients with […]

Increases and decreases in liver stiffness measurements independently predict liver-related events in NAFLD. Progression to higher stiffness levels was linked to a higher risk of liver events, while regression to lower levels decreased this risk. These findings highlight the clinical significance of monitoring liver stiffness changes as a non-invasive marker for predicting outcomes in patients […]

Arterial coverage with retromesenteric omental flap significantly reduces clinically relevant postpancreatectomy hemorrhage after pancreaticoduodenectomy. This novel technique, compared to no coverage, led to lower hemorrhage rates, fewer postoperative pancreatic fistulas, and decreased reoperation needs. Multivariate analysis confirmed the omental flap as an independent protective factor against hemorrhage. Prospective studies are encouraged to validate these promising […]

Spontaneous rupture of hepatocellular carcinoma (RHCC) poses a major threat, with mortality rates ranging from 25-75%. Recent research highlights improved survival rates and reduced complications through a treatment combination of transcatheter arterial embolization/chemoembolization (TAE/TACE) followed by elective hepatectomy. Active surveillance efforts, advanced diagnostic tools, and multidisciplinary management strategies are crucial for enhancing short and long-term […]

Minimally invasive robotic right hepatectomy with en bloc caudatectomy is safe and feasible for Bismuth IIIa hilar cholangiocarcinoma, with successful outcomes and minimal complications. The technique allows for radical resections and satisfactory postoperative recoveries, demonstrating a new surgical approach for challenging hepatic conditions. This approach offers a potential alternative for patients requiring right hemihepatectomy combined […]

Racial and socioeconomic disparities impact access to curative treatments for hepatocellular carcinoma (HCC). African-American and Hispanic patients had lower odds of receiving ablative therapy and surgical resection compared to whites, while disparities in liver transplantation varied. While trends improved for white and API/other patients, African-American and Hispanic patients showed non-significant changes over time, indicating widening […]